Project 1 - Defining the structure and function of NTS satiety circuits

项目 1 - 定义 NTS 饱腹感电路的结构和功能

• 批准号: 10263950
• 负责人: Martin G Myers
• 金额: $ 41.97万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263950
• 关键词: Acute; Agonist; Animals; Anorexia; Appetite Stimulants; Body Weight; Body Weight decreased; Brain Stem; Calcitonin; Calcitonin Receptor; Cell Nucleus; Cells; Cholecystokinin; Chronic; Consumption; Development; Diet; Eating; Feeding behaviors; Food; Food Energy; GLP-I receptor; Genes; Hypothalamic structure; Ingestion; Maintenance; Mediating; Metabolic Diseases; Motivation; Mus; Nature; Nausea; Negative Valence; Neurons; Nutrient; Nutritional; Obesity; Palate; Pharmaceutical Preparations; Pharmacology; Physiological; Physiology; Positive Reinforcements; Positive Valence; Production; Proteins; Research; Satiation; Signal Transduction; Stimulus; Structure of dorsomedial hypothalamic nucleus; Structure/Function Nuclei; Symptoms; System; Taste Perception; Techniques; Testing; Toxin; Visceral; cell type; combat; design; energy balance; feeding; gut-brain axis; hindbrain; improved; inhibitory neuron; irritation; leptin receptor; neural circuit; neuromechanism; obesity treatment; optogenetics; relating to nervous system; response; targeted treatment

Abstract Project 1- Project 1: Defining the structure and function of NTS satiety circuits While much recent energy balance-directed research has focused upon hypothalamic circuits, these hypothalamic systems largely mediate their effects on feeding via hindbrain circuits. Furthermore, many of the most effective pharmacological obesity treatments act on brainstem satiety systems. The inadvertent production of aversive symptoms such as nausea, which is mediated by circuits that are intermingled with brainstem satiety systems, represents one of the most important limitations to therapies that target these systems, however. Thus, it will be crucial to distinguish the brainstem circuits that encode satiety from those that promote nausea and other aversive symptoms, since the non-aversive circuits represent ideal targets for therapy. This project will define the neural circuits by which the NTS controls feeding and by which it signals aversive or non-aversive responses, as appropriate for the stimulus. In addition to enhancing our understanding of neural systems important for the control of ingestive behavior, distinguishing non-aversive from aversive satiety systems may permit the design of improved therapies to decrease food intake and combat obesity.

摘要项目1-项目1：确定NTS饱和电路的结构和功能 虽然最近以能量平衡为导向的研究主要集中在下丘脑 这些下丘脑系统通过后脑回路在很大程度上调节它们对进食的影响。 此外，许多最有效的药物肥胖症治疗作用于脑干。 饱腹感系统。不经意间产生的恶心等恶心症状，这是 由与脑干饱腹感系统混合的电路调节，代表了 然而，针对这些系统的治疗最重要的限制。因此，这将是至关重要的 为了区分编码饱腹感的脑干回路和促进恶心和其他疾病的脑干回路 厌恶症状，因为非厌恶回路是治疗的理想靶点。 这个项目将定义神经回路，NTS通过它来控制进食和 它发出厌恶或非厌恶反应的信号，视刺激情况而定。除了……之外 增强我们对控制摄食行为的重要神经系统的理解， 区分非厌恶性和厌恶性饱腹感系统可能允许改进的设计 减少食物摄入量和抗击肥胖的疗法。