Comprehensive Laboratory Animal Monitoring System for Core Facility

描述（由申请人提供）：啮齿动物疾病模型，特别是基因修饰的小鼠模型，为研究代谢疾病（包括肥胖症和2型糖尿病）的潜在过程提供了有力的工具。为了了解这些模型的生理学和代谢的改变，其表型的基础上，设备能够专门和精确的测量必须采用检查能量平衡和代谢变量。综合实验动物监测系统（CLAMS）连续并同时监测活动，喂养和饮水，以及VO 2和VCO 2，以确定代谢率和RQ。我们的Animal Phenotyping Core设施只有一个8笼CLAMS，无法跟上对这项服务的高需求和不断增长的需求;这种需求是由于需要这项分析的研究者和小鼠模型数量增加而产生的。目前的系统也不足以分析采用多个对照组的动物模型。购买第二个12笼系统将允许以更及时的方式分析这些动物模型，两个系统一起将能够一次分析多达20只动物。

DESCRIPTION (provided by applicant): Rodent models of disease, especially genetically-modified mouse models, have provided powerful tools to investigate the processes underlying metabolic diseases, including obesity and Type 2 diabetes. In order to understand the physiology of such models and the alterations in metabolism that underlie their phenotypes, equipment capable of specialized and precise measurements must be employed to examine energy balance and metabolic variables. The Comprehensive Laboratory Animal Monitoring System (CLAMS) continuously and simultaneously monitors activity, feeding, and drinking, as well as VO2 and VCO2 for the determination of metabolic rate and RQ. Our Animal Phenotyping Core facility has a single 8-cage CLAMS that cannot keep pace with the high and accelerating demand for this service; this demand results from the increased number of investigators and mouse models that require this analysis. The current system is also inadequate for the analysis of animal models that employ multiple control groups. The purchase of a second, 12-cage system will permit the analysis of these animal models in a more timely fashion and the two systems together will enable the analysis of up to 20 animals at one time.