(2/2) TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership

项目总结 总括 TUfccc：Grace X.Ma博士(联系Pi)和Jean-Pierre Issa医学博士(MPI) 奥洛伦森·O·奥贡沃比，医学博士(联系Pi)和Joel Erblich，博士，公共卫生硕士(MPI) 尽管在癌症的早期发现和治疗方面取得了进展，但非洲仍然存在显著的种族/民族差异， 亚太地区和西班牙裔美国人，承受着不成比例的癌症负担。这些癌症健康 差距在宾夕法尼亚州-新泽西-纽约市(PNN)地区尤为突出，那里有 与美国其他地方相比，少数族裔人口高度集中。此外，尽管有许多 在PNN地区进行生物医学研究的学术机构，严重缺乏 参与癌症研究的代表不足的少数民族(URM)，他们带来了独特的科学和文化 克服癌症健康差距所必需的优势。建立在协作历史的基础上，成功和 TUfccc和HC之间的协同规划活动/成就，以及NCI资助的癌症差异 研究网络(CNPC)，我们建议建立TUfcc/HC区域综合癌症健康 减少PNN地区癌症健康差异的差异伙伴关系。这一伙伴关系的目标是： A)建立强有力和可持续的协作性癌症健康公平研究基础设施，b)支持 培养致力于癌症研究事业的杰出的URM学生和Esis，以及c) 与社区协作，提高这些努力的质量和可行性。这些目标将是 通过以下具体目标实现：目标1.创造和加强可持续的癌症差距 TUfccc和HC之间在URM人群中的研究合作。目标1a。强化制度癌症 HC在基础、行为和临床癌症研究方面的研究能力，并为HC研究人员提供 获得TUfccc的癌症核心设施、资源和专业知识。目标1b。增加的数量 TUfccc的研究项目，重点是在全球范围内缺乏服务的人群中癌症健康差异 PNN地区。目标2.提供癌症差异方面的研究教育机会，以支持 多种多样的和URM本科生和研究生在HC和TUfccc。目标3.建立可持续的 职业发展计划，以增加研究人员的数量和多样性，以指导癌症和 在HC和TUfccc进行的癌症差异研究。目标4.使用以社区为基础的参与式研究 让研究人员、学生和社区领袖参与文化发展和实施的方法 适当的合作癌症外展、研究和教育举措，以增加获得和 在服务不足的贫富差距人群中利用癌症预防、早期发现和治疗。要实现 U54目标/目标，伙伴关系包括两个创新和严格的全面研究项目，一个试点项目和 一系列综合核心，包括研究教育、规划和评估、社区推广、 和生物统计学/生物信息学。行政核心将为伙伴关系提供监督和凝聚力。 最后，该伙伴关系得到了TUfccc和HC的高度机构承诺，而且进展良好。 为促进PNN地区及更远地区的癌症健康公平作出重大贡献。

PROJECT SUMMARY Overall TUFCCC: Grace X. Ma, PhD (Contact PI) and Jean-Pierre Issa, MD (MPI) HC: Olorunseun O. Ogunwobi, MD, PhD (Contact PI) and Joel Erblich, PhD, MPH (MPI) Despite advances in early detection and treatment of cancer, significant racial/ethnic disparities exist in African, Asian-Pacific, and Hispanic Americans, bearing disproportionate cancer burden. These cancer health disparities are particularly salient in the Pennsylvania-New Jersey-New York City (PNN) region, where there is a high concentration of minority populations compared to elsewhere in the U.S. Moreover, despite numerous academic institutions conducting biomedical research in PNN region, there is a critical dearth of underrepresented minorities (URMs) involved in cancer research, who bring unique scientific and cultural strengths necessary to conquer cancer health disparities. Building on collaborative history, successful and synergistic planning activities/accomplishments between TUFCCC and HC, and NCI-funded cancer disparities research networks (CNPC), we propose to establish TUFCCC/HC Regional Comprehensive Cancer Health Disparities Partnership to reduce cancer health disparities in PNN region. The goals of this Partnership are to: a) develop a strong and sustainable collaborative cancer health equity research infrastructure, b) support the development of outstanding URM students and ESIs who are committed to careers in cancer research, and c) collaboratively engage the community in enhancing quality and feasibility of these efforts. These goals will be achieved through the following specific aims: Aim 1. Create and enhance sustainable cancer disparity research collaborations in URM populations between TUFCCC and HC. Aim 1a. Enhance institutional cancer research capacity at HC in basic, behavioral and clinical cancer research and provide HC researchers with access to cancer core facilities, resources and expertise at TUFCCC. Aim 1b. Increase the number of research projects at TUFCCC that focus on cancer health disparities in underserved populations throughout the PNN region. Aim 2. Provide research education opportunities in cancer disparities to support a pipeline of diverse and URM undergraduate and graduate students at HC and TUFCCC. Aim 3. Establish a sustainable career development program to increase the number and diversity of investigators/ESIs to conduct cancer and cancer disparity research at both HC and TUFCCC. Aim 4. Use a Community-Based Participatory Research approach to engage researchers, students and community leaders to develop and implement culturally appropriate collaborative cancer outreach, research and education initiatives to increase access to, and utilization of cancer prevention, early detection and treatment in underserved disparity populations. To achieve U54 goals/aims, the Partnership includes two innovative and rigorous full research projects, a pilot project and a series of integrated cores, including Research Education, Planning and Evaluation, Community Outreach, and Biostatistics/Bioinformatics. Administrative Core will provide oversight and cohesion to the Partnership. Finally, the Partnership has a high level of institutional commitments from both TUFCCC and HC and is well positioned to make significant contributions to advancing cancer health equity in PNN region and beyond.