Elucidating the Roles of Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease among Asian American Patients with Chronic Hepatitis B

项目摘要 整体 格蕾丝·X Ma，PhD（联系PI）和Camille Ragin，PhD，MPH（MPI） HC：Olorunseun O. Ogunwobi，MD，PhD（联系PI）和Joel Erblich，PhD，MPH（MPI） 增强癌症健康公平性的协同伙伴关系（SPEECH）是一个高度协作和 坦普尔大学/福克斯蔡斯癌症中心（TUFCCC）和亨特之间的互利合作伙伴关系 学院（HC）和唯一的NCI资助的U 54 CPACHE在PA和新泽西州和两个在纽约市之一。我们既定 强大的研究基础设施为解决癌症健康问题做出了重大贡献 非裔美国人、亚太裔美国人和西班牙裔美国人中的冠心病差异。 这些目标人群的癌症死亡率高于美国其他人群，大多数人生活在 中等高度和持续贫困的社区。在过去的五年里，SPEECH直接支持 84名调查员，指导180名受训人员，资助56个癌症差异项目，促进93份出版物， 直接刺激了4 500万美元的外部供资赠款。此外，14名少数民族ESIs获得了职业生涯 为了取得进展，我们与50个社区组织合作，培训了41名社区卫生工作者， 对不同社区的1 200名成员进行了预防癌症的教育。利用这种成功的势头 我们的愿景是“促进包容性卓越，打破系统性障碍，缩小癌症健康差距 差异研究、教育、社区外联和参与，并实现基础设施能力 建筑”。通过特殊的机构承诺，两个正式项目，一个试点项目和综合核心项目， 行政、研究教育、生物统计学/生物信息学、规划和评估以及社区 在外联方面，我们建议实现以下具体目标。目标1：加速TUFCCCC-HC伙伴关系 跨学科的癌症差异研究合作，并促进癌症健康的公平性 基础、临床和人口科学领域。目标1a：建立、加强和维持癌症研究 能力和基础设施。目标1b：推进冠心病研究，以最大限度地发挥TUFCCC的影响。目标1c： 促进社区驱动的研究，以解决PA-NJ-NYC地区的癌症差异。目标2.培养下 一代CHD科学家和劳动力领导者，为多样化和代表性不足的学生提供渠道， 为他们提供多学科癌症差异研究教育经验和指导， 通过加强夏季癌症研究所的实施职业发展机会 以及新成立的猎人/坦普尔治愈计划目标3：招聘、指导和留住不同的ESI，特别是 URM小组，以加强职业发展，并促进他们过渡到独立的调查员。目标4。 使用双向社区参与方法来实施一个强大的社区外展计划， 在不同社区和研究人员之间建立桥梁，以支持：a）癌症教育和干预， B）癌症差异研究项目和c）研究者和受训者的CBPR能力。目标5。 进行混合方法评价，旨在监测进展情况，提供反馈和总结性影响 所有伙伴关系方案的数据，以促进可持续的解决方案，改善癌症健康的公平性。

PROJECT SUMMARY Overall TUFCCC: Grace X. Ma, PhD (Contact PI) and Camille Ragin, PhD, MPH (MPI) HC: Olorunseun O. Ogunwobi, MD, PhD (Contact PI) and Joel Erblich, PhD, MPH (MPI) The Synergistic Partnership for Enhancing Equity in Cancer Health (SPEECH) is a highly collaborative and mutually beneficial Partnership between Temple University/Fox Chase Cancer Center (TUFCCC) and Hunter College (HC) and the only NCI-funded U54 CPACHE in PA and NJ and one of two in NYC. Our established robust research infrastructure has made significant contributions to addressing substantial cancer health disparities (CHD) in underserved African American, Asian-Pacific American and Hispanic American populations. These target populations have higher cancer mortality rates compared to others in the U.S. and majority live in neighborhoods with medium-very high and persistent poverty. In the past five years, SPEECH directly supported 84 investigators, mentored 180 trainees, funded 56 cancer disparities projects, facilitated 93 publications and directly stimulated $45 million externally funded grants. Additionally, 14 minority ESIs received career advancement, we engaged 50 community-based organizations, trained 41 community health workers and educated 1200 members of diverse communities in cancer prevention. Leveraging this momentum of success our Vision is to “Promote Inclusive Excellence and break systemic barriers to close gaps in cancer health disparities research, education, community outreach and engagement, and achieve infrastructure capacity building.” Through exceptional institutional commitments, two full projects, a pilot project and integrated cores of Administrative, Research Education, Biostatistics/Bioinformatics, Planning and Evaluation, and Community Outreach, we propose to achieve the following specific aims. Aim 1: Accelerate TUFCCC-HC Partnership transdisciplinary cancer disparities research collaborations and advance cancer health equity across the spectrum of basic, clinical and population sciences. Aim 1a: build, strengthen and sustain cancer research capacities and infrastructure at HC. Aim 1b: advance CHD research to maximize impact at TUFCCC. Aim 1c: foster community-driven research to address cancer disparities in the PA-NJ-NYC region. Aim 2. Train the next generation of CHD scientists and workforce leaders for a pipeline of diverse and underrepresented students, providing them with multidisciplinary cancer disparities research education experiences and mentorship, and career development opportunities through the implementation of enhanced Summer Cancer Research Institute and newly established Hunter/Temple HEAL Program. Aim 3. Recruit, mentor and retain diverse ESIs, especially URM groups to enhance career development and facilitate their transition to independent investigators. Aim 4. Use bidirectional community engagement approaches to implement a robust community outreach program that builds bridges between diverse communities and researchers to support: a) cancer education and interventions, b) cancer disparities research projects and c) CBPR competencies for investigators and trainees. Aim 5. Conduct a mixed-method evaluation aimed at monitoring progress, providing feedback and summative impact data on all Partnership programing for promoting sustainable solutions to improved cancer health equity.