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Precision and binding as two dimensions of medial temporal lobe amnesia

内侧颞叶遗忘症二维的精确性和结合力

基本信息

批准号：
10058566
负责人：
ARNE D EKSTROM
金额：
$ 61.34万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10058566
关键词：
Affect Amnesia Area Attention Bilateral Binding Biological Assay Brain Brain Hypoxia-Ischemia Breathing Code Cognition Cognitive Cognitive deficits Complex Consensus Data Delayed Memory Dimensions Encephalitis Excision Financial compensation Functional Magnetic Resonance Imaging Grant Hippocampus (Brain)Human Impaired cognition Impairment Intervention Intractable Epilepsy Language Lesion Measures Medial Memory Modeling Network-based Neuropsychological Tests Neuropsychology Operative Surgical Procedures Outcome Partial Epilepsies Participant Patients Pattern Perception Pharmacological Treatment Pharmacology Play Population Primary Lesion Process Recovery of Function Resolution Rest Role Short-Term Memory Stroke Symptoms Temporal Lobe Testing Tissues aged base cognitive function cognitive neuroscience cognitive recovery experience experimental study flexibility gray matter improved insight long term memory neocortical nervous system disorder network models neuromechanism novel novel marker novel strategies novel therapeutics predictive modeling predictive tools recruit relating to nervous system spatial memory stroke patient theories two-dimensional way finding

项目摘要

Project Abstract Lesions to the human medial temporal result in striking and often long-lasting deficits in delayed verbal memory, termed medial temporal lobe amnesia. While models of medial temporal lobe function, such as declarative memory theory, hypothesize a restricted role for the medial temporal lobe in memory function, a growing consensus in cognitive neuroscience suggests that such deficits also include impairments in representations important to other areas of cognition, such as perception, attention, working memory, language, and spatial navigation. Here, we propose a novel model to better account for the range of cognitive deficits that accompany medial temporal lobe lesions. Our model hypothesizes that human medial temporal lobe function can best be described as involving both representational precision and binding, predicting increasing deficits as task-demands increase along these two critical dimensions. Experiments in Aim 1 test our model with a particular focus on testing representational precision in the context of memory and navigation to allow us to compare the outcomes from these experiments against those predicted by declarative memory theory. Experiments will include testing with bilateral medial temporal lobe patients, including those with lesions primarily restricted to the hippocampus, and high-resolution fMRI studies in healthy participants to better determine the mechanistic basis of hippocampal contributions to precision and binding. Aim 2 will determine the predictive capacity of our model, in conjunction with fMRI-based network modeling, to explain deficits accompanying unilateral medial temporal lesions that occur as a result of surgical resections during treatment of pharmacologically intractable epilepsy. The anticipated outcomes from the proposal are: 1) a more complete account of the consequences of medial temporal lobe lesions, particularly to the hippocampus, on cognition than can be provided by neuropsychological measures alone 2) a more complete predictive model of the effects of unilateral temporal lobe resection on cognitive outcomes post-resection, possibly allowing greater flexibility in determining which patients should undergo responsive neurostimulation (RNS) vs. resection 3) modeling whether and how extra-medial temporal lobe cortical networks can compensate for lost function following resection 4) potentially, inspiration for novel therapies involving cognitive interventions or neurostimulation targeting intact cortical tissue in patients with amnestic-like symptoms.

项目摘要