A neurocomputational model of age-related differences in navigation.
A neurocomputational model of age-related differences in navigation.
批准号:
10644265
负责人:
ARNE D EKSTROM
金额:
$19.19万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-05-15 至 2025-01-31
关键词:
AdultAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAtrophicBackBayesian ModelingBlood ScreeningBrain imagingCognitionCognitiveComputer ModelsConsensusCoupledCross-Sectional StudiesCuesDataElderlyEnvironmentGoalsHeterogeneityHippocampusHumanIllusionsImpairmentIndividualIndividual DifferencesLearningLegLocationLongitudinal StudiesMapsMedicineMetaphorModelingNatureNeuropsychologyOutcomeParticipantPatientsPatternQuality of lifeRecording of previous eventsRiskSamplingSensoryTestingTimeVariantVisualVisual IllusionsWalkingage effectage relatedaging populationcognitive skilleffective therapyentorhinal cortexexperienceexperimental studygray matterhead mounted displayhealthy aginghigh riskmild cognitive impairmentmultimodalitynovelpathological agingpreservationresponseskillsspatial memoryvirtual reality environmentway findingyoung adult
中文摘要
项目摘要:一个与年龄相关的神经计算模型
英文摘要
Project Abstract: A neurocomputational model of age-related differences in
navigation
For many individuals, navigation skills decline with increasing age, particularly for novel
environments with which the individual is not already highly familiar. Impairments in
navigation are particularly evident for those with mild cognitive impairment, a significant
risk factor for Alzheimer’s disease and Alzheimer’s related dementia (ADRD). Yet, our
understanding of age-related differences in navigation remains underdeveloped. The
dominant explanation for age-related differences in navigation relates to impairments in
the cognitive map, yet the explanatory capabilities of this model are limited, particularly
in explaining the heterogeneity of age-related differences in navigation. Here, we seek
to develop a novel computational model that employs an approximate Bayesian
framework to better account for age-related differences in navigation. We focus in
particular on testing hypotheses related to greater reliance on multimodal cue integration
(Aim 1) and strategy rigidity (Aim 2) in older adults. These ideas will be tested using
highly immersive virtual reality in which participants don a head-mounted display and
free ambulate hallways. The experiment in Aim 1 will provide critical tests of our
computational model by employing conditions involving both matching and mismatching
visual and idiothetic (body-based) cues. This will allow us to test Aim 1 and whether
older adults rely on multimodal integration to a greater extent than younger adults. The
experiment in Aim 2 will test whether older adults rely on previous trials to a greater
extent than younger adults, particularly for matching and mismatching trials. This will
allow us to test the extent to which older adults might show strategy rigidity by over-
relying on past trials. Aim 1&2 will also allow us to test ideas related to individual
differences in navigation strategies, which can be assessed based on the variability in
subject responses within the different conditions tested. Finally, we will test a subset of
individuals with mild cognitive impairment (MCI) to provide initial and exploratory testing
of their navigational deficits in our experiments. The outcomes of this project have the
potential to provide a new understanding of age-related differences in navigation by
developing a sophisticated and novel computational model that we test in detail with
experiments in immersive virtual reality.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Characterizing the cognitive computations underlying spatial navigation
-
批准号:10726662
-
项目类别:
-
资助金额:$41.19万
-
财政年份:2023
-
负责人:ARNE D EKSTROM
-
依托单位:
Precision and binding as two dimensions of medial temporal lobe amnesia
-
批准号:10398901
-
项目类别:
-
资助金额:$53.9万
-
财政年份:2020
-
负责人:ARNE D EKSTROM
-
依托单位:
Precision and binding as two dimensions of medial temporal lobe amnesia
-
批准号:10178134
-
项目类别:
-
资助金额:$53.9万
-
财政年份:2020
-
负责人:ARNE D EKSTROM
-
依托单位:
Precision and binding as two dimensions of medial temporal lobe amnesia
-
批准号:10058566
-
项目类别:
-
资助金额:$61.34万
-
财政年份:2020
-
负责人:ARNE D EKSTROM
-
依托单位:
Precision and binding as two dimensions of medial temporal lobe amnesia
-
批准号:10617720
-
项目类别:
-
资助金额:$53.9万
-
财政年份:2020
-
负责人:ARNE D EKSTROM
-
依托单位:
Volumetric and connectivity measures of navigation and memory skill acquisition
-
批准号:10115363
-
项目类别:
-
资助金额:$43.41万
-
财政年份:2020
-
负责人:ARNE D EKSTROM
-
依托单位:
Testing a Novel Theoretical Framework for the Human Medial Temporal Lobes in Perception and Memory During Spatial Navigation
-
批准号:9102285
-
项目类别:
-
资助金额:$7.09万
-
财政年份:2015
-
负责人:ARNE D EKSTROM
-
依托单位:
Testing a Novel Theoretical Framework for the Human Medial Temporal Lobes in Perception and Memory During Spatial Navigation
-
批准号:8949358
-
项目类别:
-
资助金额:$7.14万
-
财政年份:2015
-
负责人:ARNE D EKSTROM
-
依托单位:
Mapping Human Memory with Electrocorticography & Chronometric Stimulation
-
批准号:8824066
-
项目类别:
-
资助金额:$21.65万
-
财政年份:2014
-
负责人:ARNE D EKSTROM
-
依托单位:
Mapping Human Memory with Electrocorticography & Chronometric Stimulation
-
批准号:8934204
-
项目类别:
-
资助金额:$18.06万
-
财政年份:2014
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation and Binding of Spatial and Temporal Episodic Memories in Human Hippocampus
-
批准号:9084639
-
项目类别:
-
资助金额:$32.08万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation and Binding of Spatial and Temporal Episodic Memories in Human Hip
-
批准号:8372251
-
项目类别:
-
资助金额:$32.89万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation and Binding of Spatial and Temporal Episodic Memories in Human Hip
-
批准号:8686971
-
项目类别:
-
资助金额:$37.35万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation of spatiotemporal information in human episodic memory and navigation
-
批准号:9919002
-
项目类别:
-
资助金额:$35.48万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation and Binding of Spatial and Temporal Episodic Memories in Human Hip
-
批准号:8611401
-
项目类别:
-
资助金额:$5.46万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation of spatiotemporal information in human episodic memory and navigation
-
批准号:10378639
-
项目类别:
-
资助金额:$33.95万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation of spatiotemporal information in human episodic memory and navigation
-
批准号:10160967
-
项目类别:
-
资助金额:$35.48万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Representation and Binding of Spatial and Temporal Episodic Memories in Human Hip
-
批准号:8501709
-
项目类别:
-
资助金额:$31.21万
-
财政年份:2012
-
负责人:ARNE D EKSTROM
-
依托单位:
Correlating Human Electrophysiology and BOLD Activity
-
批准号:7242572
-
项目类别:
-
资助金额:$4.64万
-
财政年份:2005
-
负责人:ARNE D EKSTROM
-
依托单位:
Correlating Human Electrophysiology and BOLD Activity
-
批准号:6997449
-
项目类别:
-
资助金额:$4.4万
-
财政年份:2005
-
负责人:ARNE D EKSTROM
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: