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Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma

Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma
早期黑色素瘤甲基化改变和突变负担的性别差异
批准号：
10063456
负责人：
MARIANNE BERWICK
金额：
$9.6万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-06-01 至 2023-05-31
来源：
https://reporter.nih.gov/project-details/10063456
关键词：
AddressAdjuvantAmerican Joint Committee on CancerAustraliaBiological AssayClinicalDNA MethylationDNA Sequence AlterationDataEpigenetic ProcessEvaluationGoalsImmunotherapyLinkMemorial Sloan-Kettering Cancer CenterMethylationMutationParentsPatientsPrimary NeoplasmRelapseResourcesRoleSex DifferencesTNMUnited StatesWomanbiological sexinsightmelanomamelanoma biomarkersmenmethylomeprogramspublic health relevancesextumor

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英文摘要
PROJECT SUMMARY/ABSTRACT The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1) identifying underlying mechanisms for observed disparities in melanoma overall survival between men and women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex and survival.
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