Sex Differences in Methylome Alterations and Mutational Burden in Early Stage Melanoma

早期黑色素瘤甲基化改变和突变负担的性别差异

• 批准号: 10063456
• 负责人: MARIANNE BERWICK
• 金额: $ 9.6万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10063456
• 关键词: Address; Adjuvant; American Joint Committee on Cancer; Australia; Biological Assay; Clinical; DNA Methylation; DNA Sequence Alteration; Data; Epigenetic Process; Evaluation; Goals; Immunotherapy; Link; Memorial Sloan-Kettering Cancer Center; Methylation; Mutation; Parents; Patients; Primary Neoplasm; Relapse; Resources; Role; Sex Differences; TNM; United States; Woman; biological sex; insight; melanoma; melanoma biomarkers; men; methylome; programs; public health relevance; sex; tumor

PROJECT SUMMARY/ABSTRACT The proposed project aims to address a current gap in our understanding of the role of biological sex in overall survival among melanoma AJCC TNM stages IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID. We will evaluate methylome alterations and mutational burden in the primary tumors of 1000 melanoma patients with the goal of 1) identifying underlying mechanisms for observed disparities in melanoma overall survival between men and women, and 2) identifying subclasses of methylome alterations and mutational signatures associated with sex and survival.

项目总结/摘要 拟议的项目旨在解决目前我们对生物性别在整体中的作用的理解存在的差距。 黑色素瘤AJCC TNM分期IIA/IIB/IIC/IIIA/IIIB/IIIC/IIID的生存率。我们将评估甲基化 1000例黑色素瘤患者原发性肿瘤中的改变和突变负荷，目标是1） 确定观察到的男性之间黑色素瘤总生存率差异的潜在机制， 2）鉴定与性别相关的甲基化组改变和突变特征的亚类 和生存