West Virginia Pediatric Clinical Trials Network-2

西弗吉尼亚州儿科临床试验 Network-2

• 批准号: 10064509
• 负责人: LESLEY A COTTRELL
• 金额: $ 41.79万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10064509
• 关键词: Acceleration; Acute; Address; Appalachian Region; Behavior Therapy; Characteristics; Child; Child Health; Childhood; Chronic; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Disease; Economics; Effectiveness; Environmental Risk Factor; Faculty; Fostering; Funding; Goals; Health; Human Resources; Hypertension; Infant; Infrastructure; Institutes; Intervention; Investigation; Lead; Leadership; Mentors; Methods; Mission; Multicenter Trials; Neonatal Abstinence Syndrome; Outcome; Pediatric Research; Performance; Positioning Attribute; Prevention; Research; Research Infrastructure; Research Personnel; Resources; Rural Population; Site; Standardization; Structure; Teacher Professional Development; Training; Translational Research; Underserved Population; Ursidae Family; West Virginia; Work; catalyst; clinical research site; experience; follow-up; in utero; insight; interest; neonate; opioid epidemic; opioid exposure; psychosocial; recruit; rurality; skills; success; tool; trend

Abstract West Virginia (WV) bears long-standing physical, psychosocial and fiscal characteristics, including the opioid crisis, limited resources and a restricted economy, that have significantly impacted the health of its residents. The West Virginia Pediatric Clinical Trials Network (WVPCTN), as a Clinical Site of the ECHO IDeA States PCTN (ISPCTN), has catalyzed emerging solutions to address some of these burdens by fulfilling its mission. Specifically, the mission of the WVPCTN has been two-fold - bringing clinical trials to our underserved population, and building professional capacity for clinical research. Our WVU site has been well positioned to be a successful Clinical Site due to a combination of structural and human resources that were already in place when the ISPCTN was initiated in 2016, and the background and expertise of the three PIs – Drs. Saul, Pyles and Cottrell. The addition of the funds and resources provided by ISPCTN led to an acceleration of WVUs capacity to actively participate in clinical trials by allowing us to create a dedicated Pediatric Research Unit (PRU) and introduce a group of junior, less experienced clinical trial investigators, into both ISPCTN and non-ISPCTN trials. The effectiveness of this approach has been demonstrated through an increase in faculty participation in ISPCTN activities, a strong recruitment record, and an increase in the number of non-ISPCTN Pediatric trials at WVU. The WVPCTN is now actively growing an experienced investigator pool and a group of mentee investigators, all enhanced by the resources and expertise of the West Virginia Clinical Translational Science Institute (WVCTSI). These features and resources, together with strong and sustained partnerships throughout the state, and the multiple environmentally related conditions of our citizens, continue to uniquely position us to be successful as an ISPCTN Clinical Site and work to propose new trials for the network. This proposal for WVPCTN-2 will further add to a long-standing commitment to Pediatric-focused initiatives across the state. When funded, it will continue to position us to fully leverage additional funds that support Pediatric research infrastructure and provide access to cutting edge trials, both of which will positively impact the health of the children of WV.

摘要 西弗吉尼亚州（WV）具有长期的身体，心理和财政特征，包括阿片类药物 危机、有限的资源和受限制的经济严重影响了居民的健康。 西弗吉尼亚州儿科临床试验网络（WVPCTN），作为ECHO IDEA States PCTN的临床研究中心 （ISPCTN）通过履行其使命，促成了解决其中一些负担的新解决方案。 具体来说，WVPCTN的使命是双重的--为我们服务不足的人群带来临床试验， 并建立临床研究的专业能力。我们的西弗吉尼亚大学网站已经被定位为一个成功的 由于ISPCTN时已经到位的结构和人力资源的组合， 于2016年启动，三位PI的背景和专业知识-扫罗博士，Pyles博士和Cottrell博士。的 由于ISPCTN提供的资金和资源的增加，WVU的能力得到了加速， 参与临床试验，允许我们创建一个专门的儿科研究单位（PRU），并引入一个 一组资历较浅、经验较少的临床试验研究者，参与ISPCTN和非ISPCTN试验。的 这种方法的有效性已经通过增加教师参与ISPCTN得到了证明 活动，一个强大的招聘记录，并在非ISPCTN儿科试验在西弗吉尼亚大学的数量增加。 WVPCTN现在正在积极发展一个经验丰富的调查员库和一组学员调查员， 通过西弗吉尼亚临床转化科学研究所（WVCTSI）的资源和专业知识得到加强。 这些特点和资源，加上全州强大和持续的伙伴关系， 我们的公民的多种环境相关的条件，继续独特的定位，我们是成功的， 一个ISPCTN临床站点，并致力于为网络提出新的试验。WVPCTN-2的提案将进一步 增加了对全州儿科重点倡议的长期承诺。一旦获得资金， 使我们能够充分利用额外的资金来支持儿科研究基础设施， 到尖端试验，这两项试验都将对西弗吉尼亚州儿童的健康产生积极影响。