The Oklahoma Pediatric Clinical Trials Network

俄克拉荷马州儿科临床试验网络

• 批准号: 10063789
• 负责人: PAUL M DARDEN
• 金额: $ 39.79万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10063789
• 关键词: Address; Adult; African American; Airway Disease; American Indians; Area; Cancer Center; Child; Child Health; Child health care; Childhood; Clinical; Clinical Informatics; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Clinical Trials Unit; Collaborations; Communities; Community Developments; Community Medicine; Conduct Clinical Trials; County; Development; Diabetes Mellitus; Economics; Enrollment; Evaluation; Faculty; Family; Geography; Goals; Growth; Health; Health Benefit; Health Personnel; Health Sciences; Health Services Accessibility; Health Status; Healthcare; Healthcare Systems; Home environment; Income; Infrastructure; Institutes; Journals; Latino; Leadership; Learning; Life; Medical; Medical Informatics; Mentors; Minority; Multi-Institutional Clinical Trial; Nature; Network Infrastructure; Nursing Faculty; Obesity; Oklahoma; Outcome; Outcome Study; Overweight; Phase; Physicians; Population; Positioning Attribute; Primary Health Care; Provider; Publications; Research; Research Personnel; Research Priority; Research Project Grants; Resource Informatics; Resources; Rural; Rural Community; Rural Population; Schools; Site; Smoking; System; Training; Translational Research; Underrepresented Populations; Underserved Population; United States; Universities; base; behavioral health intervention; clinical implementation; clinical trial participant; design; experience; feasibility trial; informatics infrastructure; interest; medical schools; member; neurodevelopment; outreach; pediatric department; postnatal; practice-based research network; racial and ethnic; recruit; research study; rural underserved; statistics; trial design; tribal health

PROJECT SUMMARY/ABSTRACT The goal of the Oklahoma Pediatric Clinical Trials Network (OPCTN) is to provide access for the underserved rural, urban minority, and American Indian populations of children in Oklahoma to state-of-the-art clinical trials and the transfer of findings that will benefit the health of those children. The OPCTN will continue to be a member of the Environmental influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN). The ISPCTN facilitates involvement of sites in IDeA states to design and implement clinical trials related to the 5 primary ECHO focus areas: 1) upper and lower airway disease, 2) obesity; 3) pre-, peri-, and postnatal outcomes; 4) neurodevelopment; and 5) positive child health. These are each areas of substantial health concern for Oklahoma, where our overall child health is rated amongst the worst in the United States. The first phase of OPCTN was successful in developing capacity for pediatric clinical trials through mentoring of junior clinical investigators, building clinical informatics resources, leadership with the ISPCTN network, and participation ISPCTN-led trials. The OPCTN was consistently among the top three recruiting sites within the network and led the development of an ISPCTN feasibility trial focused on rural populations. For this renewal phase of the OPCTN, we have assembled a diverse mixture of resources within Oklahoma. It is centered in the Department of Pediatrics and the Oklahoma Clinical and Translational Science Institute at the University of Oklahoma Health Sciences Center. It combines the resources of Oklahoma’s IDeA-CTR, the Oklahoma Shared Clinical and Translational Resources, academic physicians at the state’s allopathic medical school, clinical trials experts at the Stephenson Cancer Center, providers in Oklahoma urban and rural communities, and practice-based research networks in order to broaden the opportunities for children in Oklahoma to participate in clinical research studies. The OPCTN engages with community consultant groups that represent the American Indian, Latino, and African American communities as well as county-based health improvement organizations within the state to allow their input on research project design, implementation, and community participatory interest. The OPCTN also focuses on training pediatric clinicians and research staff to enhance their experience in the design and conduct of clinical trials in order to increase the capacity of the medical community in the state to conduct clinical and translational research efforts.

项目概要/摘要 俄克拉荷马州儿科临床试验网络 (OPCTN) 的目标是为 为俄克拉荷马州服务不足的农村、城市少数民族和美洲印第安人儿童提供最先进的服务 临床试验和研究结果的转让将有利于这些儿童的健康。 OPCTN 将继续 成为环境对儿童健康结果影响 (ECHO) IDeA 国家儿科组织的成员 临床试验网络 (ISPCTN)。 ISPCTN 促进 IDeA 州的站点参与设计和 实施与 5 个主要 ECHO 重点领域相关的临床试验：1) 上呼吸道和下呼吸道疾病，2) 肥胖; 3) 产前、围产期和产后结果； 4）神经发育； 5) 积极的儿童健康。这些都是 俄克拉荷马州的每个重大健康问题领域，我们的儿童整体健康状况被评为 美国最差。 OPCTN 第一阶段成功开发了儿科临床试验能力 指导初级临床研究人员、建立临床信息学资源、与 ISPCTN 进行领导 网络，并参与 ISPCTN 主导的试验。 OPCTN 始终位居前三名招聘网站之列 并领导了针对农村人口的 ISPCTN 可行性试验的开发。 在 OPCTN 的更新阶段，我们在俄克拉荷马州汇集了多种资源。 它以儿科和俄克拉荷马州临床与转化科学研究所为中心 俄克拉荷马大学健康科学中心。它结合了俄克拉荷马州 IDeA-CTR 的资源， 俄克拉荷马州共享临床和转化资源，该州对抗疗法医学的学术医生 学校、史蒂芬森癌症中心的临床试验专家、俄克拉荷马州城乡的提供者 社区和基于实践的研究网络，以扩大儿童的机会 参加俄克拉荷马州临床研究。 OPCTN 与社区顾问团体合作 代表美洲印第安人、拉丁裔和非裔美国人社区以及县级卫生部门 州内的改进组织允许他们对研究项目的设计、实施和 社区参与兴趣。 OPCTN 还重点培训儿科临床医生和研究人员 增强他们在设计和进行临床试验方面的经验，以提高临床试验的能力 该州医学界开展临床和转化研究工作。