Factors impacting locomotor learning following stroke

影响中风后运动学习的因素

基本信息

批准号：
10053683
负责人：
Margaret French
金额：
$ 1.16万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2021-02-14
项目状态：
已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Stroke often results in numerous physical impairments that limit functional mobility, making it the leading cause of long-term disability in the United States. A primary goal for rehabilitation professionals and stroke survivors is to improve walking abilities. Despite significant efforts to improve walking, many stroke survivors are unable to walk independently after their stroke. This is in part due to variability in how stroke survivors respond to rehabilitation interventions. Because motor learning is the foundation for effective rehabilitation interventions, variability in locomotor learning after stroke is one source of this variability. To date, there is almost no information on factors that account for this variability, making if challenging to customize post stroke rehabilitation interventions. Previous research has examined demographic information and sensorimotor impairments as potential factors to explain variability in locomotor learning after stroke; however, these factors have not been found to explain a significant portion of variability. In healthy adults, cognition has been found to explain variability in learning upper extremity tasks, but this has not been examined in walking or after stroke, where cognitive deficits are common. Thus, the overall goal of this proposal is to determine the relationship between cognition and locomotor learning after stroke. In Aim 1 we will examine the relationship between learning a new walking pattern and fluid cognition in stroke survivors. In Aim 2, we will examine the relationship between remembering the new walking pattern (i.e. retention) and fluid cognition in stroke survivors. The results of this project will address critical gaps in our understanding of locomotor learning after stroke and allow us to better customize rehabilitation interventions to optimize post stroke outcomes. Additionally, this proposed work serves as a first step towards the long-term goal of this fellowship applicant, which is to become a successful clinician scientist focused on developing personalized rehabilitation interventions that optimize functional recovery after stroke. By completing this fellowship proposal under the guidance of experienced mentors in a strong research environment, the applicant will receive the training needed to successfully complete the proposed work, to develop into a productive scientist, and to achieve her long term career goals.

项目摘要/摘要中风通常会导致大量的身体障碍，这些障碍限制了功能性活动性，使其成为主要原因美国长期残疾。康复专业人员和中风幸存者的主要目标是为了提高步行能力。尽管为改进步行而做出了重大努力，但许多中风幸存者还是无法他们中风后独立行走。这部分是由于中风幸存者如何应对康复干预措施。因为运动学习是有效康复干预措施的基础中风后运动学习的变异性是这种变异性的来源。迄今为止，几乎没有有关说明这种变异性的因素的信息，如果具有挑战性，可以定制中风后康复干预措施。先前的研究检查了人口统计信息和感觉运动障碍是解释中风后运动运动变异性的潜在因素；但是，这些因素尚未发现可以解释很大一部分可变性。在健康的成年人中，认知已被发现解释学习上肢任务的可变性，但这在行走或中风后尚未进行检查，认知缺陷很常见的地方。因此，该提案的总体目标是确定关系中风后认知和运动学习之间。在AIM 1中，我们将研究在中风幸存者中学习新的步行模式和流体认知。在AIM 2中，我们将研究关系在记住新的步行模式（即保留）和中风幸存者中的流体认知之间。这该项目的结果将解决我们对中风后运动学习的理解时的关键差距，并允许我们可以更好地定制康复干预措施，以优化邮政中的中风结果。此外，这提出了工作是朝着该奖学金申请人的长期目标迈出的第一步，这将成为一个成功的临床医生科学家致力于开发个性化的康复干预措施，以优化中风后的功能恢复。通过在经验丰富的指导下完成该奖学金建议在强大的研究环境中的导师，申请人将获得成功的培训完成拟议的工作，发展成为一位富有成效的科学家，并实现她的长期职业目标。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of an Acute High Intensity Exercise Bout on Retention of Explicit, Strategic Locomotor Learning in Individuals With Chronic Stroke.

DOI：
10.1177/15459683231195039
发表时间：
2023-09
期刊：
NEUROREHABILITATION AND NEURAL REPAIR
影响因子：
4.2
作者：
Thompson, Elizabeth D.;Bhat, Soumya;French, Margaret A.;Morton, Susanne;Pohlig, Ryan T.;Reisman, Darcy S.
通讯作者：
Reisman, Darcy S.

Fluid Cognition Relates to Locomotor Switching in Neurotypical Adults, Not Individuals After Stroke.