Epidemiology, impact, and experience of acne in transgender persons

跨性别者痤疮的流行病学、影响和经历

• 批准号: 10055481
• 负责人: Howa Yeung
• 金额: $ 15.78万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10055481
• 关键词: Accounting; Acne; Address; Adult; Adverse effects; Age; Androgens; Antiandrogen Therapy; Area; Arthritis; Asthma; Benefits and Risks; Birth; Carcinoma; Caring; Characteristics; Chronic Disease; Clinical; Clinical Practice Guideline; Clinical Trials; Collection; Communities; Cutaneous; Data; Data Collection; Development; Diabetes Mellitus; Diagnosis; Epidemiology; Feeling suicidal; Feminization; Funding; Future; Gender; Gender Identity; Goals; Health; Health Status; Healthcare Systems; High Prevalence; Hormonal; Hormone use; Hormones; Impaired health; Impairment; Incidence; Individual; Intervention; Interview; Knowledge; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Minority; Modeling; Multicenter Studies; National Institute of Child Health and Human Development; Natural History; Oral Contraceptives; Outcome; Outcomes Research; Pathogenesis; Patient Recruitments; Patients; Persons; Population; Prevalence; Prospective Studies; Prospective cohort study; Protocols documentation; Psoriasis; Quality of life; Race; Research; Research Methodology; Research Personnel; Research Technics; Research Training; Retrospective Studies; Severities; Sexual Health; Sexual and Gender Minorities; Site; Skin; Stress; Surveys; Techniques; Testing; Testosterone; Training; Well in self; Woman; base; career; clinical practice; cohort; comorbidity; cost; design; disability burden; disparity reduction; experience; gender dysphoria; health care disparity; health care settings; health disparity; health related quality of life; high risk; hormone therapy; improved; interest; keratinocyte; melanoma; men; multidisciplinary; patient oriented; recruit; self esteem; sex; skin disorder; social; theories; transfeminine; transgender; transmasculine

PROJECT SUMMARY / ABSTRACT The overall objective of this K23 proposal is to support new research training and experience crucial for the candidate, Howa Yeung, MD MSc, to become an independent, patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Acne significantly impairs health-related quality of life and is associated with depression, low self-esteem, and suicidal ideation. Little is known about the interplay of endogenous and exogenous hormones on acne incidence, severity, impact, treatment, and experience. Our prior studies noted higher acne prevalence associated with hormone therapy and identified specific barriers for severe acne treatment in transgender persons. This proposal aims to examine the epidemiology, impact, and experience of acne in the context of hormone therapy in transgender persons – a health disparity population with significant knowledge gaps in skin health. The epidemiology of acne will be examined using data from the existing large-scale, validated, multicenter Study of Transition, Outcomes and Gender (STRONG). Factors that mediate differences in acne experience, treatment, and research participation will be newly elicited using mixed methods. Development and pilot testing of a recruitment protocol and collection of preliminary data on acne outcomes and mental health comorbidity will help initiate a prospective cohort study of acne in transgender persons receiving hormone therapy. To achieve these aims, the candidate will require additional training through a combination of formal didactics, practical research experience, and expert multidisciplinary mentorship. The candidate will build expertise in sexual and gender minority health and health disparities research, patient-oriented outcomes research in acne, mixed- methods research techniques, as well as experience in community-engaged research and patient recruitment. The candidate’s mentored training and research plans will enable him to launch a successful career as an independent patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Key results will inform new acne and gender-affirming hormone treatment paradigms and the design and implementation of future interventions, aimed to reduce the identified acne disparities, optimize acne clinical outcomes, and to improve patient-centeredness of hormone therapy in transgender persons.

项目摘要/摘要