Epidemiology, impact, and experience of acne in transgender persons

跨性别者痤疮的流行病学、影响和经历

基本信息

批准号：
10669589
负责人：
Howa Yeung
金额：
$ 15.78万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-20 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669589
关键词：
Acne Address Adult Adverse effects Age Androgens Antiandrogen Therapy Area Arthritis Asthma Benefits and Risks Birth Carcinoma Caring Characteristics Chronic Disease Clinical Clinical Practice Guideline Clinical Trials Collection Cutaneous Data Data Collection Development Diabetes Mellitus Diagnosis Disparity Epidemiology Feeling suicidal Feminization Funding Future Gender Gender Identity Goals Health Health Disparities Research Health Status Healthcare Systems High Prevalence Hormonal Hormone use Hormones Impaired health Impairment Incidence Individual Intervention Interview Knowledge Measures Mediating Mediator Mental Depression Mental Health Mental disorders Mentors Mentorship Methods Modeling Multicenter Studies National Institute of Child Health and Human Development National Institute on Minority Health and Health Disparities Natural History Oral Contraceptives Outcome Outcomes Research Pathogenesis Patient Recruitments Patient-Focused Outcomes Patients Persons Population Prevalence Prospective Studies Prospective, cohort study Protocols documentation Psoriasis Quality of life Race Research Research Methodology Research Personnel Research Technics Research Training Retrospective Studies Severities Sexual Health Sexual and Gender Minorities Site Skin Surveys Techniques Testosterone Training Well in self Woman career clinical practice cohort community engaged research comorbidity cost design disability burden disparity reduction experience future implementation gender affirming hormone therapy gender dysphoria gender minority group gender minority health gender minority health disparity health care disparity health care settings health disparity populations health related quality of life high risk hormone therapy improved interest keratinocyte melanoma men minority disparity minority health minority stress multidisciplinary patient oriented pilot test recruit self esteem sex skin disorder social theories transfeminine transgender transmasculine

项目摘要

PROJECT SUMMARY / ABSTRACT The overall objective of this K23 proposal is to support new research training and experience crucial for the candidate, Howa Yeung, MD MSc, to become an independent, patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Acne significantly impairs health-related quality of life and is associated with depression, low self-esteem, and suicidal ideation. Little is known about the interplay of endogenous and exogenous hormones on acne incidence, severity, impact, treatment, and experience. Our prior studies noted higher acne prevalence associated with hormone therapy and identified specific barriers for severe acne treatment in transgender persons. This proposal aims to examine the epidemiology, impact, and experience of acne in the context of hormone therapy in transgender persons – a health disparity population with significant knowledge gaps in skin health. The epidemiology of acne will be examined using data from the existing large-scale, validated, multicenter Study of Transition, Outcomes and Gender (STRONG). Factors that mediate differences in acne experience, treatment, and research participation will be newly elicited using mixed methods. Development and pilot testing of a recruitment protocol and collection of preliminary data on acne outcomes and mental health comorbidity will help initiate a prospective cohort study of acne in transgender persons receiving hormone therapy. To achieve these aims, the candidate will require additional training through a combination of formal didactics, practical research experience, and expert multidisciplinary mentorship. The candidate will build expertise in sexual and gender minority health and health disparities research, patient-oriented outcomes research in acne, mixed- methods research techniques, as well as experience in community-engaged research and patient recruitment. The candidate’s mentored training and research plans will enable him to launch a successful career as an independent patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Key results will inform new acne and gender-affirming hormone treatment paradigms and the design and implementation of future interventions, aimed to reduce the identified acne disparities, optimize acne clinical outcomes, and to improve patient-centeredness of hormone therapy in transgender persons.

项目摘要 /摘要该K23提案的总体目标是支持新的研究培训，并经验对候选人，医学博士Howa Yeung，成为一名独立的，以患者为导向的调查员以及皮肤疾病的性别少数差异 - 例如变性人的痤疮。痤疮显着损害与健康相关的生活质量，并与抑郁，低自尊和自杀想法有关。对于痤疮事件，严重程度，影响，治疗和经验。我们先前的研究指出，与骑马有关的痤疮患病率较高治疗并确定了跨性别者严重痤疮治疗的特定障碍。该建议旨在在跨基因的马酮治疗背景下检查痤疮的流行病学，影响和经验人 - 皮肤健康知识差异的健康差异人群。流行病学痤疮将使用现有的大规模，经过验证的多中心过渡研究的数据进行检查，结果和性别（强大）。介导痤疮经验，治疗和研究参与将使用混合方法新引起。开发和试点测试招募方案和收集有关痤疮结果和心理健康合并症的初步数据有助于启动接受马龙治疗的跨性别者痤疮的前瞻性队列研究。实现这些目的，候选人将需要通过形式教学，实用的结合进行额外的培训研究经验和专家多学科指导。候选人将建立性方面的专业知识性别少数族裔健康与健康差异研究，面向患者的痤疮结果研究，混合方法研究技术以及社区参与研究和患者招聘方面的经验。候选人的修复培训和研究计划将使他能够从事成功的职业独立面向患者的研究者针对皮肤病中的性和性别少数分布 - 例如跨性别者的痤疮。关键结果将为新的痤疮和性别肯定提供信息治疗范例以及未来干预措施的设计和实施，旨在减少所确定的在变性人。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dermatologic care of patients with differences of sex development.

DOI：
10.1097/jw9.0000000000000106
发表时间：
2023-10
期刊：
International journal of women's dermatology
影响因子：
0
作者：
Gold, Sarah;Huang, Christina;Radi, Rakan;Gupta, Pranav;Felner, Eric I;Haw, Jeehea Sonya;Childress, Krista;Sokkary, Nancy;Tangpricha, Vin;Goodman, Michael;Yeung, Howa
通讯作者：
Yeung, Howa

Cutaneous and Noncutaneous Adverse Effects in Patients with Advanced Melanoma Receiving Immunotherapy.

DOI：
10.1016/j.xjidi.2023.100232
发表时间：
2023-11
期刊：
JID innovations : skin science from molecules to population health
影响因子：
0
作者：
Yeung, Howa;Supapannachart, Krittin J;Francois, Sandy;Adler, Colin H;Kudchadkar, Ragini R;Lawson, David H;Yushak, Melinda L;Shariff, Afreen I;Chen, Suephy C
通讯作者：
Chen, Suephy C

Use and cost of skin biopsy procedures in the Medicare Part B fee-for-service population, 2017 to 2020.

2017 年至 2020 年 Medicare B 部分付费服务人群中皮肤活检程序的使用和费用。

DOI：
10.1007/s00403-023-02618-1
发表时间：
2023
期刊：
Archives of dermatological research
影响因子：
3
作者：
Li,Yiwen;Blalock,Travis;DuszakJr,Richard;Yeung,Howa
通讯作者：
Yeung,Howa

Satisfaction with current hormone therapy and goals of additional gender-affirming care in transgender adults.

对跨性别成人当前激素治疗的满意度以及额外性别肯定护理的目标。

DOI：
10.1093/jsxmed/qdad011
发表时间：
2023
期刊：
The journal of sexual medicine
影响因子：
0
作者：
Siira,Meron;Getahun,Darios;Silverberg,MichaelJ;Tangpricha,Vin;Goodman,Michael;Yeung,Howa
通讯作者：
Yeung,Howa

Developing and implementing approaches to limit antimicrobial resistance.