Cerenkov Multi-Spectral Imaging (CMSI) for Adaptation and Real-Time Imaging in Radiotherapy
Cerenkov Multi-Spectral Imaging (CMSI) for Adaptation and Real-Time Imaging in Radiotherapy
批准号:
10080509
负责人:
Issam M. El Naqa
金额:
$32.72万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-02 至 2021-11-30
关键词:
AcidityAnimalsArchitectureAreaBiological AssayBreastBreast Cancer PatientCancer CenterCancer PatientCell Culture TechniquesCharacteristicsClinicClinicalClinical ResearchCollaborationsComplexComputer SimulationCost SavingsCustomDataDetectionDevelopmentDevicesDiagnosticDiscipline of Nuclear MedicineDoseEnvironmentEquipmentEvaluationExposure toExternal Beam Radiation TherapyFeedbackFour-dimensionalGenerationsGoalsHead CancerHead and Neck CancerHead and neck structureHumanHypoxiaImageImaging technologyIn VitroIndustrializationInjectionsInnovation CorpsInterviewJointsKnowledgeLeadLegal patentLesionLightLinear Accelerator Radiotherapy SystemsLogisticsMeasurementMeasuresMedical DeviceMethodsMichiganModalityMolecularMolecular TargetMonitorMonte Carlo MethodMusNeck CancerNormal tissue morphologyOncologyOpticsOrganismOutcomeOxygenPathway interactionsPatient-Focused OutcomesPatientsPerformancePhasePhotonsPhysicsPhysiologicalPositron-Emission TomographyPre-Clinical ModelPublic HealthRadiationRadiation DosageRadiation Dose UnitRadiation OncologyRadiation therapyRadioisotopesResearch PersonnelScanningSecureSensitivity and SpecificityShapesSignal TransductionSiliconSmall Business Technology Transfer ResearchSpectrum AnalysisSystemTargeted RadiotherapyTechniquesTechnologyTestingTherapeuticTimeTissue ModelTissuesTranslationsTreatment EfficacyUniversitiesUse of New TechniquesWorkXenograft procedurebasecancer radiation therapyclinical applicationcommercial applicationcommercializationcostcost effectivedesigndetectordosimetryemission spectroscopyexperienceflexibilityimage guidedimaging approachimaging modalityimaging probeimaging systemimprovedimproved outcomein vitro testingin vivoinnovationirradiationlight emissionmalignant breast neoplasmmembermolecular diagnosticsmolecular imagingmouse modelnovelnuclear imagingpatient safetyphotomultiplierpressureprogramsprototyperadiation detectorreal-time imagesresponsescale upsingle photon emission computed tomographysolid statespectrographtargeted imagingtechnological innovationtooltumortumor microenvironment
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Understanding of tumor molecular characteristics during a course of radiotherapy (RT)
treatment is crucial to assess the efficacy of the treatment and adapt radiation dosage to
optimize outcomes. Unfortunately, this cannot be routinely achieved by current diagnostic
nuclear imaging modalities due to complex logistics and prohibitive costs. Alternatively,
Cerenkov Emission (CE) is an optical phenomenon that accompanies external beam radiation
from a linear accelerator and has been demonstrated for in vivo dosimetry and spectroscopy
during radiotherapy. This approach shows great potential, but the low photon response from
commercially available detectors has limited its impact in clinical radiotherapy practice. The
recent development of highly sensitive, compact silicon photomultiplier (SiPM) devices enables
arrays of CE detectors to be customized in any shape and placed directly on a patient’s body to
provide a much enhanced signal, thus enabling CE to become a new, routine clinical tool for
daily molecular tumor characterization during radiation treatment. This Phase I STTR will
assess the feasibility of this revolutionary Cerenkov Multi-Spectral Imaging (CMSI) innovation,
which is the product of collaboration between researchers in the Radiation Oncology and
Applied Physics Departments at the University of Michigan, and Endectra LLC, a 2015 spinout
from the University of Michigan which specializes in the development of novel radiation
detectors utilizing SiPM technology and Cerenkov light analytics. In this project, Endectra will
lead several on-body SiPM probe/array prototyping, scale-up, and testing cycles, while
collaborating radiation oncology researchers provide device performance feedback, assess the
advantages of CMSI over other commercial approaches, and test the hypothesis that improved
detection of CE (at low photon counts) can yield improved utility in real-time tumor molecular
characterization. Specific aims of this effort include the evaluation of CMSI-SiPM arrays for 1)
their capacity to spectrally probe tumor molecular microenvironment and calibrate their
performance in vitro using cell culture assays, and 2) their capacity to determine tumor
aggressiveness/response and assess delivered dose in vivo using xenograft mouse models. We
expect to demonstrate that CMSI can simultaneously determine delivered dose while
spectroscopically characterizing tumor response to radiotherapy on a daily basis and in real
time. If successful, Endectra could proceed to a Phase II effort including human trials,
development of CMSI probes for multiple clinical applications, and development of the
substantial commercial opportunity for this innovation in the radiotherapy equipment market.
This would result in a paradigm shift in radiotherapy image-guidance, greatly improved patient
safety and therapeutic impact, and a major improvement to public health.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.ejmp.2021.02.024
发表时间:
2021-03
期刊:
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
影响因子:
--
作者:
[Balagurunathan Y, Mitchell R, El Naqa I]
通讯作者:
El Naqa I
DOI:
10.1002/mp.15662
发表时间:
2022-06
期刊:
MEDICAL PHYSICS
影响因子:
3.8
作者:
[El Naqa, Issam, Pogue, Brian W., Zhang, Rongxiao, Oraiqat, Ibrahim, Parodi, Katia]
通讯作者:
Parodi, Katia
DOI:
10.1016/j.ejmp.2020.08.015
发表时间:
2020-10
期刊:
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
影响因子:
--
作者:
[Zlateva Y, Muir BR, El Naqa I, Seuntjens J]
通讯作者:
Seuntjens J
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
-
批准号:10582051
-
项目类别:
-
资助金额:$47.98万
-
财政年份:2023
-
负责人:Issam M. El Naqa
-
依托单位:
Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:10416058
-
项目类别:
-
资助金额:$45.72万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Federated Learning for Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:10417829
-
项目类别:
-
资助金额:$15.87万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:10669029
-
项目类别:
-
资助金额:$45.72万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:10299634
-
项目类别:
-
资助金额:$46.37万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:9816658
-
项目类别:
-
资助金额:$45.13万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Optimal Decision Making in Radiotherapy Using Panomics Analytics
-
批准号:10250778
-
项目类别:
-
资助金额:$33.84万
-
财政年份:2019
-
负责人:Issam M. El Naqa
-
依托单位:
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
-
批准号:10245972
-
项目类别:
-
资助金额:$49.48万
-
财政年份:2018
-
负责人:Issam M. El Naqa
-
依托单位:
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
-
批准号:9594556
-
项目类别:
-
资助金额:$61.52万
-
财政年份:2018
-
负责人:Issam M. El Naqa
-
依托单位:
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
-
批准号:10470308
-
项目类别:
-
资助金额:$48.96万
-
财政年份:2018
-
负责人:Issam M. El Naqa
-
依托单位:
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
-
批准号:10261532
-
项目类别:
-
资助金额:$48.96万
-
财政年份:2018
-
负责人:Issam M. El Naqa
-
依托单位:
Predicting Radiotherapy Outcomes by Combining Physical and Biological Factors
-
批准号:7470386
-
项目类别:
-
资助金额:$13.15万
-
财政年份:2008
-
负责人:Issam M. El Naqa
-
依托单位:
Predicting Radiotherapy Outcomes by Combining Physical and Biological Factors
-
批准号:7622168
-
项目类别:
-
资助金额:$13.15万
-
财政年份:2008
-
负责人:Issam M. El Naqa
-
依托单位:
海外基金