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Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability
驱动压力诱发成瘾脆弱性的遗传机制的发现和表征
批准号：
10116573
负责人：
Price Evans Dickson
金额：
$24.9万
依托单位：
MARSHALL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-07-01 至 2023-06-30
来源：
https://reporter.nih.gov/project-details/10116573
关键词：
AdultAffectAutomobile DrivingBehaviorBiologicalBiological AssayBiological ModelsBrainBrain regionChemosensitizationChronicCocaineCorticosteroneDSM-IVDataDendritic SpinesDevelopmentDiseaseDissectionDrug AddictionDrug usageEnvironmental Risk FactorExhibitsExposure toFoundationsFutureGene ExpressionGenesGeneticGenetic Predisposition to DiseaseGenetic VariationGenomeGenomicsGenotypeGoalsGoldHormonesHousingHumanInbred MouseIndividualIntravenousLabelLeadMeasuresMethodsModelingMorphologyMusNatural regenerationNeurobiologyNeurosciencesNucleus AccumbensPathway interactionsPhenotypePopulationPredispositionPublic HealthRandomizedRattusRecombinantsResistanceResourcesRewardsRodentSelf AdministrationStressSubstance abuse problemThe Jackson LaboratoryTissuesTransgenesaddictioncocaine exposuredensitydifferential expressiongenetic resistancehuman diseaseillicit drug useindexinglaser capture microdissectionmultiple drug usenovelpreferencepublic health relevanceresistant straintraittranscriptome sequencing

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PROJECT SUMMARY Drug addiction is a critical public health issue with genetic and environmental causes. Worldwide, 246 million adults used an illicit drug in 2013, and > 10% of these users met DSM-IV criteria for substance abuse. Stress is a key environmental variable driving the development of addiction, and this effect is under strong genetic control. Despite tremendous
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Discovery of genetic and genomic mechanisms driving the relationship between social reward and cocaine addiction
  • 批准号：
    10664000
  • 项目类别：
  • 资助金额：
    $18.5万
  • 财政年份：
    2022
  • 负责人：
    Price Evans Dickson
  • 依托单位：
    MARSHALL UNIVERSITY
Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability
  • 批准号：
    10202537
  • 项目类别：
  • 资助金额：
    $24.9万
  • 财政年份：
    2020
  • 负责人：
    Price Evans Dickson
  • 依托单位：
    MARSHALL UNIVERSITY
Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability
  • 批准号：
    10433982
  • 项目类别：
  • 资助金额：
    $24.9万
  • 财政年份：
    2020
  • 负责人：
    Price Evans Dickson
  • 依托单位：
    MARSHALL UNIVERSITY
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