Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

驱动压力诱发成瘾脆弱性的遗传机制的发现和表征

• 批准号: 10202537
• 负责人: Price Evans Dickson
• 金额: $ 24.9万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202537
• 关键词: Adult; Affect; Automobile Driving; Behavior; Biological; Biological Assay; Biological Models; Brain; Brain region; Chemosensitization; Chronic; Cocaine; Corticosterone; DSM-IV; Data; Dendritic Spines; Development; Disease; Dissection; Drug Addiction; Drug usage; Environmental Risk Factor; Exhibits; Exposure to; Foundations; Future; Gene Expression; Genes; Genetic; Genetic Predisposition to Disease; Genetic Variation; Genome; Genomics; Genotype; Goals; Gold; Hormones; Housing; Human; Inbred Mouse; Individual; Intravenous; Label; Lead; Measures; Methods; Modeling; Morphology; Mus; Natural regeneration; Neurobiology; Neurosciences; Nucleus Accumbens; Pathway interactions; Phenotype; Population; Predisposition; Public Health; Randomized; Rattus; Recombinants; Resistance; Resources; Rewards; Rodent; Stress; Substance abuse problem; The Jackson Laboratory; Tissues; Transgenes; addiction; cocaine exposure; cocaine self-administration; density; differential expression; genetic resistance; human disease; illicit drug use; indexing; laser capture microdissection; multiple drug use; novel; preference; public health relevance; resistant strain; trait; transcriptome sequencing

PROJECT SUMMARY Drug addiction is a critical public health issue with genetic and environmental causes. Worldwide, 246 million adults used an illicit drug in 2013, and > 10% of these users met DSM-IV criteria for substance abuse. Stress is a key environmental variable driving the development of addiction, and this effect is under strong genetic control. Despite tremendous

项目摘要 药物成瘾是一个严重的公共卫生问题，有遗传和环境原因。全球2.46亿 2013年，成年人使用非法药物，其中超过10%的使用者符合DSM-IV药物滥用标准。应力 是一个关键的环境变量驱动成瘾的发展，这种影响是在强大的遗传 控制尽管巨大的