驱动压力诱发成瘾脆弱性的遗传机制的发现和表征-猫眼课题宝

驱动压力诱发成瘾脆弱性的遗传机制的发现和表征

批准号：

10202537

负责人：

Price Evans Dickson

金额：

$24.9万

依托单位：

MARSHALL UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-07-01 至 2023-06-30

来源：

https://reporter.nih.gov/project-details/10202537

关键词：

Adult Affect Automobile Driving Behavior Biological Biological Assay Biological Models Brain Brain region Chemosensitization Chronic Cocaine Corticosterone DSM-IV Data Dendritic Spines Development Disease Dissection Drug Addiction Drug usage Environmental Risk Factor Exhibits Exposure to Foundations Future Gene Expression Genes Genetic Genetic Predisposition to Disease Genetic Variation Genome Genomics Genotype Goals Gold Hormones Housing Human Inbred Mouse Individual Intravenous Label Lead Measures Methods Modeling Morphology Mus Natural regeneration Neurobiology Neurosciences Nucleus Accumbens Pathway interactions Phenotype Population Predisposition Public Health Randomized Rattus Recombinants Resistance Resources Rewards Rodent Stress Substance abuse problem The Jackson Laboratory Tissues Transgenes addiction cocaine exposure cocaine self-administration density differential expression genetic resistance human disease illicit drug use indexing laser capture microdissection multiple drug use novel preference public health relevance resistant strain trait transcriptome sequencing

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中文摘要

翻译

项目摘要药物成瘾是一个严重的公共卫生问题，有遗传和环境原因。全球2.46亿 2013年，成年人使用非法药物，其中超过10%的使用者符合DSM-IV药物滥用标准。应力是一个关键的环境变量驱动成瘾的发展，这种影响是在强大的遗传控制尽管巨大的

英文摘要

PROJECT SUMMARY Drug addiction is a critical public health issue with genetic and environmental causes. Worldwide, 246 million adults used an illicit drug in 2013, and > 10% of these users met DSM-IV criteria for substance abuse. Stress is a key environmental variable driving the development of addiction, and this effect is under strong genetic control. Despite tremendous

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Discovery of genetic and genomic mechanisms driving the relationship between social reward and cocaine addiction

批准号：

10664000
项目类别：
资助金额：

$18.5万
财政年份：

2022
负责人：

Price Evans Dickson
依托单位：

MARSHALL UNIVERSITY

Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

批准号：

10433982
项目类别：
资助金额：

$24.9万
财政年份：

2020
负责人：

Price Evans Dickson
依托单位：

MARSHALL UNIVERSITY

Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

批准号：

10116573
项目类别：
资助金额：

$24.9万
财政年份：

2020
负责人：

Price Evans Dickson
依托单位：

MARSHALL UNIVERSITY

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