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Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction Vulnerability

驱动压力诱发成瘾脆弱性的遗传机制的发现和表征

基本信息

批准号：
10433982
负责人：
Price Evans Dickson
金额：
$ 24.9万
依托单位：
MARSHALL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10433982
关键词：
Adult Affect Automobile Driving Behavior Biological Biological Assay Biological Models Brain Brain region Chemosensitization Chronic Cocaine Corticosterone DSM-IV Data Dendritic Spines Development Disease Dissection Drug Addiction Drug usage Environmental Risk Factor Exhibits Exposure to Foundations Future Gene Expression Genes Genetic Genetic Predisposition to Disease Genetic Variation Genome Genomics Genotype Goals Gold Hormones Housing Human Inbred Mouse Individual Intravenous Label Lead Measures Methods Modeling Morphology Mus Natural regeneration Neurobiology Neurosciences Nucleus Accumbens Pathway interactions Phenotype Population Predisposition Public Health Randomized Rattus Recombinants Resistance Resources Rewards Rodent Stress Substance abuse problem The Jackson Laboratory Tissues Transgenes addiction addiction liability cocaine exposure cocaine self-administration density differential expression genetic resistance human disease illicit drug use indexing laser capture microdissection multiple drug use novel preference public health relevance resistant strain trait transcriptome sequencing

项目摘要

PROJECT SUMMARY Drug addiction is a critical public health issue with genetic and environmental causes. Worldwide, 246 million adults used an illicit drug in 2013, and > 10% of these users met DSM-IV criteria for substance abuse. Stress is a key environmental variable driving the development of addiction, and this effect is under strong genetic control. Despite tremendous

项目总结吸毒成瘾是一个严重的公共卫生问题，有遗传和环境原因。全球，2.46亿 2013年，成年人使用非法药物，其中10%的吸毒者符合DSM-IV药物滥用标准。压力是推动成瘾发展的关键环境变量，这种影响是由强烈的遗传因素造成的控制力。尽管有巨大的

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Strain and sex dependent effects of isolation housing relative to environmental enrichment on operant sensation seeking in mice.

DOI：
10.1038/s41598-021-97252-0
发表时间：
2021-09-08
期刊：
Scientific reports
影响因子：
4.6
作者：
Dickson PE;Mittleman G
通讯作者：
Mittleman G

Environmental enrichment influences novelty reactivity, novelty preference, and anxiety via distinct genetic mechanisms in C57BL/6J and DBA/2J mice.

DOI：
10.1038/s41598-021-83574-6
发表时间：
2021-02-16
期刊：
Scientific reports
影响因子：
4.6
作者：
Dickson PE;Mittleman G
通讯作者：
Mittleman G

Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice.

微生物谷氨酸代谢预测多样性远交小鼠静脉注射可卡因的自我给药。

DOI：
10.1016/j.neuropharm.2022.109409
发表时间：
2023-03-15
期刊：
NEUROPHARMACOLOGY
影响因子：
4.7
作者：
Tran, Thi Dong Binh;Nguyen, Hoan;Sodergren, Erica;Dickson, Price E.;Wright, Susan N.;Philip, Vivek M.;Weinstock, George M.;Chesler, Elissa J.;Zhou, Yanjiao;Bubier, Jason A.
通讯作者：
Bubier, Jason A.

Working memory and pattern separation in founder strains of the BXD recombinant inbred mouse panel.