CTSA KL2 Supplement Rebecca Grzadzinski

CTSA KL2 补充 Rebecca Grzadzinski

• 批准号: 10117614
• 负责人: Morris Weinberger
• 金额: $ 10.95万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117614
• 关键词: Address; Administrative Supplement; Age; Age-Months; Amygdaloid structure; Behavior Therapy; Biological Markers; Brain; Brain imaging; Cerebrospinal Fluid; Characteristics; Child; Child Development; Childhood; Clinical Sciences; Communication; Complex; Data; Development; Diagnosis; Diagnostic; Disease; Down Syndrome; Etiology; Exhibits; Funding; General Population; Genetic; Goals; Grant; Heritability; Impairment; Incidence; Infant; Institutes; Intervention; K-Series Research Career Programs; Link; Live Birth; Longevity; Longitudinal cohort; Measurement; Mendelian disorder; Molecular Abnormality; Neurobiology; Neurodevelopmental Disorder; North Carolina; Phenotype; Prospective Studies; Publishing; Research; Research Personnel; Sampling; School-Age Population; Severities; Shapes; Social Development; Social Environment; Structure; Symptoms; Therapeutic Intervention; Time; Translational Research; Universities; autism spectrum disorder; brain behavior; brain morphology; brain volume; career development; cohort; early childhood; imaging study; infancy; novel therapeutics; postnatal; programs; prospective; repetitive behavior; response; social communication; social relationships; social situation; targeted treatment; translational scientist; white matter

This application is submitted in response to NOT-OD-20-022 as an administrative supplement to NCATS CTSA Program KL2 Institutional Career Development Awards. The highly-successful University of North Carolina (UNC) Institutional Career Development Award KL2 program is housed within the UNC Translational and Clinical Sciences (TraCS) Institute and aims to shape the development of junior translational scientists such as the applicant of this proposal. The overarching goal of this proposal is to characterize longitudinal, brain-behavior trajectories, and developmental profiles from infancy through school-age in Down Syndrome (DS) compared to Autism Spectrum Disorder (ASD). The specific aims are to 1) characterize age-, disorder- and social communication (SC)-specific brain features in DS children from infancy through school age and 2) describe SC development during infancy and school age in DS children. This project is the first to address the lack of studies that 1) examine the onset and trajectory of SC symptoms in children with DS during infancy, 2) combine SC phenotyping with brain features in an early postnatal prospective, longitudinal sample and 3) compare brain biomarkers between with DS, iASD, and TD children both in infancy and childhood. This unparalleled opportunity to generate comprehensive trajectories of SC deficits in children with DS leverages data across four grants that are part of the Infant Brain Imaging Study (IBIS) Network making this large-scale, complex project feasible. This proposal addresses the goals of NCATS CTSA Program, the TraCS KL2 Program, and the INCLUDE Project in the following ways, 1) Funding this scholar’s project increases the translational workforce of DS researchers, 2) This project utilizes prospective, longitudinal cohorts of children with DS, ASD, and typical development (TD) thereby addressing the INCLUDE goal to investigate co-occurring conditions across the lifespan, and 3) integrates multiple fields in order to accelerate the development of new therapies and interventions for DS. Completion of this project will result in rich information about the development of SC and brain biomarkers for DS, ASD, and TD children with the aim of accelerating the development of new SC therapies and interventions for DS children.

本申请是作为对NOT-OD-20-022的回应提交的， NCATS CTSA计划KL 2机构职业发展奖。非常成功的 北卡罗来纳州大学（University of North Carolina）机构职业发展奖KL 2计划是 该研究所位于美国转化和临床科学研究所（TraCS）内，旨在塑造 发展初级翻译科学家，如本提案的申请人。的 这项提议的首要目标是描述纵向的大脑行为轨迹， 唐氏综合征（DS）从婴儿期到学龄期的发育概况， 自闭症谱系障碍（ASD）。具体目标是：1）表征年龄、障碍和 从婴儿期到学龄期DS儿童社会交往（SC）特异性脑特征 （2）描述DS儿童在婴儿期和学龄期的SC发展。该项目是 首先解决缺乏研究，1）检查SC症状的发作和轨迹， 婴儿期患有DS的儿童，2）在早期将联合收割机SC表型与大脑特征结合， 出生后前瞻性纵向样本和3）比较DS之间的脑生物标志物， iASD和TD儿童，包括婴儿期和儿童期。这个无与伦比的机会， DS儿童SC缺陷的综合轨迹利用了四项赠款的数据 婴儿脑成像研究（IBIS）网络的一部分， 项目可行。该提案涉及NCATS CTSA计划的目标，TraCS KL 2 计划，并包括以下方式项目，1）资助这个学者的项目 增加了DS研究人员的翻译劳动力，2）该项目利用了前瞻性， 患有DS、ASD和典型发育（TD）的儿童的纵向队列，从而解决 INCLUDE的目标是调查整个生命周期中共同发生的情况，以及3）整合 多个领域，以加速DS新疗法和干预措施的开发。 该项目的完成将为SC和脑的发育提供丰富的信息 DS，ASD和TD儿童的生物标志物，旨在加速新的 DS儿童的SC治疗和干预。