Genetic modifiers of Alzheimer Risk Administrative Supplement

阿尔茨海默病风险管理补充剂的基因修饰剂

• 批准号: 10121529
• 负责人: Mary E Dickinson
• 金额: $ 39.7万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-28 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121529
• 关键词: Administrative Supplement; Age; Alzheimer disease detection; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Biological Assay; Biological Markers; Blood; Blood Screening; DNA Damage; Detection; Disease; Early Diagnosis; Genetic; Individual; Knock-out; Knockout Mice; Medicine; Modeling; Phenotype; Prevention; Production; Property; Risk; Signal Transduction; Symptoms; Time; Work; base; blood-based biomarker; college; disease phenotype; mouse model; mutant; pre-clinical; response; risk variant; sex

Genetic Modifiers of Alzheimer Risk Administrative Supplement We have identified a blood biomarker signal that differentiates genetically mutant Alzheimer disease (AD)-model mice from their age- and sex-matched non-mutant littermates: markers of the cellular response to DNA damage. This supplement to the KOMP project will define the detection limits of the assay signal in time, pre-disease, and breadth of models detectable, and will examine viable knock-out mice generated in the KOMP project for signal in the blood assay as a simple screen for knock-outs with AD and pre-AD properties. This work has the potential to identify new AD risk alleles, and to produce a simple, early initial blood-based biomarker and assay for AD risk. Simple blood screens for pre-AD phenotypes could allow identification and potentially prevention of symptoms in at-risk individuals not otherwise identified.

阿尔茨海默病风险管理补充的遗传修饰物 我们已经确定了一种血液生物标志物信号，可以区分基因突变的阿尔茨海默病(AD)模型 来自年龄和性别匹配的非突变小鼠：细胞对DNA损伤反应的标志。 KOMP项目的这一补充将定义检测信号的及时、疾病前和 可检测到的模型的广度，并将检查KOMP项目中产生的可存活的基因敲除小鼠的信号 在血液检测中，作为一种简单的筛选具有AD和AD前期特性的基因敲除。这项工作有潜力 识别新的AD风险等位基因，并产生一种简单的、早期的基于血液的AD生物标志物和检测方法 风险。对AD前期表型进行简单的血液筛查可以识别并潜在地预防 高危个体的症状未经其他方式识别。