Feedback controlled, ultra-high-precision drug delivery
反馈控制的超高精度药物输送
基本信息
- 批准号:10084266
- 负责人:
- 金额:$ 48.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-14 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimal WelfareAnimalsArchitectureArea Under CurveBiological MarkersBrainChemicalsClinicClinicalClinical ResearchCommunitiesComplexDevelopmentDoseDrug Delivery SystemsDrug KineticsDrug MonitoringDrug toxicityEnsureExhibitsFeedbackFoundationsFrequenciesGoalsHealth StatusHourHumanIn SituInfectionIntravenousMaintenanceMapsMeasurementMeasuresMedical ResearchMetabolismMethodsMolecularMusNatureOutcomePathologyPatientsPeripheralPharmaceutical PreparationsPharmacological TreatmentPharmacologyPhysiologyPlasmaProgram DevelopmentRattusReproducibilityResearchResearch PersonnelRunningSafetySiteSolid NeoplasmTechnologyTechnology TransferTestingTherapeuticTherapeutic InterventionTimeTissuesTranslatingTreatment EffectivenessTumor TissueValidationWorkaptamerawakebaseclinical practicecohortdrug testingefficacy studyimprovedin vivoinnovationmolecular markerpersonalized medicineprecision drugspreclinical studyprogramsresearch and developmentresponserisk minimizationsensorsimulationtemporal measurementtheoriestherapy outcometool
项目摘要
We have demonstrated the first ever example of closed-loop feedback control over plasma drug levels
informed by real-time in-vivo drug measurements. We achieved this using a sensing architecture that is
independent of the chemical reactivity of the target molecule, rendering the approach, at least in theory,
generalizable to any drug. Here we propose a research and development program aimed at translating this
innovative breakthrough into a powerful new tool applicable to both pharmacological research and clinical
practice. By improving (by orders of magnitude) the precision with which we can control in-vivo drug levels, the
proposed technology would render pharmacokinetics an experimentally controllable parameter, allowing
researchers to more precisely map the relationships between pharmacokinetics and clinical outcomes, to
eliminate pharmacokinetic inconsistency as a confounding experimental variable, and to accurately simulate
human pharmacokinetics in animal models. Ultimately, such a technology could be used in the clinic where, by
optimize dosing moment-to-moment in response to a patient's changing metabolism, it would ensure that a
therapy's benefits are maximized while its risks are minimized.
我们已经展示了有史以来第一个闭环反馈控制血浆药物水平的例子
项目成果
期刊论文数量(0)
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Kevin W Plaxco其他文献
Kevin W Plaxco的其他文献
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{{ truncateString('Kevin W Plaxco', 18)}}的其他基金
Biostable nucleic acid aptamers for long-duration, in vivo molecular monitoring
用于长时间体内分子监测的生物稳定核酸适体
- 批准号:
10304801 - 财政年份:2021
- 资助金额:
$ 48.96万 - 项目类别:
Biostable nucleic acid aptamers for long-duration, in vivo molecular monitoring
用于长时间体内分子监测的生物稳定核酸适体
- 批准号:
10430240 - 财政年份:2021
- 资助金额:
$ 48.96万 - 项目类别:
Feedback controlled, ultra-high-precision drug delivery
反馈控制的超高精度药物输送
- 批准号:
10321612 - 财政年份:2019
- 资助金额:
$ 48.96万 - 项目类别:
Feedback controlled, ultra-high-precision drug delivery
反馈控制的超高精度药物输送
- 批准号:
9761770 - 财政年份:2019
- 资助金额:
$ 48.96万 - 项目类别:
Bio-electrochemical detectors for in vivo continuous monitoring
用于体内连续监测的生物电化学检测器
- 批准号:
9238429 - 财政年份:2017
- 资助金额:
$ 48.96万 - 项目类别:
Bio-electrochemical detectors for in vivo continuous monitoring
用于体内连续监测的生物电化学检测器
- 批准号:
9551624 - 财政年份:2017
- 资助金额:
$ 48.96万 - 项目类别:
A new tool for measuring surface-biomolecule interactions
测量表面生物分子相互作用的新工具
- 批准号:
8662567 - 财政年份:2014
- 资助金额:
$ 48.96万 - 项目类别:
A new approach to quantitative, point-of-care serology
定量、护理点血清学的新方法
- 批准号:
9306748 - 财政年份:2014
- 资助金额:
$ 48.96万 - 项目类别:
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