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Multimodal Gating Mechanisms of TRPV1 Ion Channels

Multimodal Gating Mechanisms of TRPV1 Ion Channels
TRPV1 离子通道的多模态门控机制
批准号：
10082453
负责人：
Sharona E Gordon
金额：
$41.99万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-01-01 至 2022-12-31
来源：
https://reporter.nih.gov/project-details/10082453
关键词：
AgonistAmino AcidsBindingBiologicalCapsaicinCellsComputing MethodologiesCoupledCouplingDataDevelopmentFluorescence Resonance Energy TransferGoalsIon ChannelIonsLibrariesLigandsLightLipidsMeasurementMeasuresMembraneMembrane ProteinsMetal Binding SiteMethodsModalityModelingMolecularMolecular ConformationNaturePainPain managementPhosphatidylinositol 4,5-DiphosphatePositioning AttributeProtein EngineeringProtonsPublishingQuality of lifeSavorySideSignal TransductionStimulusStructureSystemTRPV1 geneTemperatureTestingTimeToxinTransition Elementsanandamidebasecapsazepinechemical propertychronic painclinically relevantexperimental studyextracellularimprovedinnovationmaltose-binding proteinmultimodalitynon-opioid analgesicnovelnovel strategiespain receptorphysical propertyside effecttool

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英文摘要
Project summary The goal of this proposal is to determine the molecular mechanisms underlying multi-modal gating of the pain-receptor ion channel TRPV1 by interrogating the structural mechanisms for activation by capsaicin, heat, protons, savory compounds, and signaling lipids. We will use tmFRET and computational methods to determine the conformational change induced by each modality and the coupling between modalities.
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Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels
  • 批准号：
    10590571
  • 项目类别：
  • 资助金额：
    $40.43万
  • 财政年份：
    2022
  • 负责人：
    Sharona E Gordon
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels
  • 批准号：
    10793400
  • 项目类别：
  • 资助金额：
    $23.41万
  • 财政年份：
    2022
  • 负责人：
    Sharona E Gordon
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels
  • 批准号：
    10627103
  • 项目类别：
  • 资助金额：
    $6.65万
  • 财政年份：
    2022
  • 负责人：
    Sharona E Gordon
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels
  • 批准号：
    10404753
  • 项目类别：
  • 资助金额：
    $46.09万
  • 财政年份：
    2022
  • 负责人：
    Sharona E Gordon
  • 依托单位：
    UNIVERSITY OF WASHINGTON
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