Husbandry and Management Core
畜牧与管理核心
基本信息
- 批准号:10083096
- 负责人:
- 金额:$ 14.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AIDS-Related Opportunistic InfectionsAIDS/HIV problemAcquired Immunodeficiency SyndromeAdultAnimal ModelAnimalsAnti-Retroviral AgentsArtificial InseminationBehavioralBreedingDevelopmentDiseaseDisease SurveillanceFemaleFunctional disorderGenetic VariationGoalsGrantHIVHIV InfectionsHIV vaccineHealthHerpesvirus 1Immune responseInfantInfectionMacaca mulattaModelingMonitorMycobacterium tuberculosisOutcomePathogenesisPharmaceutical PreparationsPractice ManagementPreventive careResearchResourcesRiskSIVSerology testSimian RetrovirusesTarget PopulationsTherapy EvaluationVaccine ResearchVaccinesVirusWeight maintenance regimenZoonosesanimal breedingantiretroviral therapybaseclinical careenzooticfight againstgerm free conditioninnovationnonhuman primatepreservationprogramspsychologicscreeningsocial
项目摘要
PROJECT SUMMARY, Core A: Husbandry and Management Core
The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus
macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic
virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian
origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV
pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines.
Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable
supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs.
The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free
(SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder
females capable of producing at least 120 surplus animals annually for research use. To achieve this we will
provide innovative team based management practices including new social monitoring strategies, a weight
management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and
introduction of an artificial insemination program to expand genetic diversity.
项目总结,核心A:畜牧与管理核心
项目成果
期刊论文数量(0)
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