Husbandry and Management Core

畜牧与管理核心

• 批准号: 10083096
• 负责人: Kamm Prongay
• 金额: $ 14.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10083096
• 关键词: AIDS-Related Opportunistic Infections; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Anti-Retroviral Agents; Artificial Insemination; Behavioral; Breeding; Development; Disease; Disease Surveillance; Female; Functional disorder; Genetic Variation; Goals; Grant; HIV; HIV Infections; HIV vaccine; Health; Herpesvirus 1; Immune response; Infant; Infection; Macaca mulatta; Modeling; Monitor; Mycobacterium tuberculosis; Outcome; Pathogenesis; Pharmaceutical Preparations; Practice Management; Preventive care; Research; Resources; Risk; SIV; Serology test; Simian Retroviruses; Target Populations; Therapy Evaluation; Vaccine Research; Vaccines; Virus; Weight maintenance regimen; Zoonoses; animal breeding; antiretroviral therapy; base; clinical care; enzootic; fight against; germ free condition; innovation; nonhuman primate; preservation; programs; psychologic; screening; social

PROJECT SUMMARY, Core A: Husbandry and Management Core The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines. Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs. The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free (SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder females capable of producing at least 120 surplus animals annually for research use. To achieve this we will provide innovative team based management practices including new social monitoring strategies, a weight management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and introduction of an artificial insemination program to expand genetic diversity.

项目总结，核心A：畜牧业和管理核心 用于艾滋病研究的U42 SPF 4恒河猴繁殖群体产生MHC-1类恒河猴 猴免疫缺陷病毒(SIV)阴性的猕猴(猕猴)，猴T淋巴细胞 病毒(STLV-1)、猿猴逆转录病毒(D型逆转录病毒或SRV)和猕猴疱疹病毒-1(BV)。SPF4印度人 猕猴是艾滋病毒/艾滋病研究的主要动物模型，包括艾滋病毒研究 与艾滋病相关的机会性感染，以及艾滋病毒治疗和疫苗的发展。 对这一资源的需求继续增长，预计在赠款周期内还会增加。一个可预见的 提供无疾病、具有基因特征的非人类灵长类动物在抗击艾滋病毒/艾滋病方面至关重要。 畜牧业和管理核心的总体目标是保持ONPRC特定病原体的无 (SPF)用于艾滋病研究的恒河猴繁育群体，目标人群为175名成年繁殖者 雌性能够每年生产至少120只多余的动物用于研究。为了实现这一目标，我们将 提供基于团队的创新管理实践，包括新的社会监控战略、权重 高危婴儿管理计划，结核分支杆菌筛查的血清学检测，以及 引入人工授精计划，扩大遗传多样性。