Husbandry and Management Core

畜牧与管理核心

• 批准号: 10083096
• 负责人: Kamm Prongay
• 金额: $ 14.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10083096
• 关键词: AIDS-Related Opportunistic Infections; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Anti-Retroviral Agents; Artificial Insemination; Behavioral; Breeding; Development; Disease; Disease Surveillance; Female; Functional disorder; Genetic Variation; Goals; Grant; HIV; HIV Infections; HIV vaccine; Health; Herpesvirus 1; Immune response; Infant; Infection; Macaca mulatta; Modeling; Monitor; Mycobacterium tuberculosis; Outcome; Pathogenesis; Pharmaceutical Preparations; Practice Management; Preventive care; Research; Resources; Risk; SIV; Serology test; Simian Retroviruses; Target Populations; Therapy Evaluation; Vaccine Research; Vaccines; Virus; Weight maintenance regimen; Zoonoses; animal breeding; antiretroviral therapy; base; clinical care; enzootic; fight against; germ free condition; innovation; nonhuman primate; preservation; programs; psychologic; screening; social

PROJECT SUMMARY, Core A: Husbandry and Management Core The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines. Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs. The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free (SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder females capable of producing at least 120 surplus animals annually for research use. To achieve this we will provide innovative team based management practices including new social monitoring strategies, a weight management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and introduction of an artificial insemination program to expand genetic diversity.

项目总结，核心A：畜牧与管理核心