Core D: Clinical Recruitment

将设立一个核心，以支持在三个研究项目中对人体受试者的调查。这 临床学科和招聘核心将为学科招聘、筛查提供集中资源 和招生。项目1将采用由Pi Bockenstedt共同开发的现有临床站点网络 康涅狄格州，包括耶鲁-纽黑文医疗系统，以及在波特兰，缅因州和曼斯菲尔德，康涅狄格州 招募莱姆病患者。项目2的招聘将由合作者在#年进行。 德克萨斯州(西尼罗河病毒(WNV)感染)，但也将包括康涅狄格州的西尼罗河病毒感染者。 项目3将利用已经从以前登记的队列中收集的样本；此外，Young(21岁- 30)、非虚弱和虚弱的老年人(年龄≥70)将参加大剂量流感疫苗的研究 总部设在康涅狄格州纽黑文。该核心还将负责确保安全和信息 为所有参与者提供安全保障，并确保遵守所有监管措施。核心将负责 维护和部署我们已建立的用于生成主题编号的条形码样本系统， 跟踪样本，并映射到外部ID，与核心B(数据管理和分析)合作， 数据管理平台所在的位置。核心由具有丰富经验的调查人员领导 进行人体免疫学研究，具有必要的监管和临床经验。 因此，这个临床学科和招募核心将推动人类免疫学的目标 项目联合体申请。

A Core will be established to support investigations on human subjects in the three research projects. This Clinical Subjects and Recruitment Core will provide a centralized resource for subject recruitment, screening and enrollment. Project 1 will employ a pre-existing network of clinical sites developed by co-PI Bockenstedt in Connecticut, including the Yale-New Haven Health System, and in Portland, Maine and Mansfield, CT for recruitment of participants with Lyme Disease. Project 2 recruitment will be carried out by collaborators in Texas (for West Nile Virus (WNV) infection), but will also include participants in Connecticut with WNV disease. Project 3 will utilize already-collected samples from a previously enrolled cohort; in addition, young (age 21- 30), non-frail and frail older (age ≥70) adults will be enrolled for a study of the high-dose influenza vaccine based in New Haven, Connecticut. This Core will also be responsible for ensure safety and information security for all participants and for compliance with all regulatory measures. The Core will be responsible for maintaining and deploying our established barcoding sample system for generation of subject numbers, tracking of samples, and mapping to external IDs, collaborating with Core B (Data Management and Analysis), where data management platforms are based. The Core is led by investigators with extensive experience carrying out human immunology studies who have the necessary regulatory and clinical experience. Consequently, this Clinical Subjects and Recruitment Core will advance the goals of this Human Immunology Project Consortium application.