Midcareer Award in Translational Immunology of Aging

衰老转化免疫学职业中期奖

• 批准号: 9759735
• 负责人: Albert C Shaw
• 金额: $ 18.76万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9759735
• 关键词: 21 year old; Adult; Affect; Age; Aging; American; Area; Award; Biogenesis; Biological Models; Biometry; Blood specimen; Capsicum; Clinical; Collaborations; Communicable Diseases; Comorbidity; Computational Biology; Computing Methodologies; Development; Development Plans; Doctor of Philosophy; Dose; Elderly; Elements; Environment; Foundations; Funding; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic; Geriatrics; Gerontology; Grant; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human; Immune; Immune response; Immune system; Immunologics; Immunologist; Immunology; Immunophenotyping; Infection; Inflammatory; Influenza; Influenza vaccination; Infrastructure; Innate Immune System; Internal Medicine; Laboratories; Laboratory Research; Leptospirosis; Medical; Medicine; Mentors; Mentorship; Metabolic; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Mitochondria; Molecular Immunology; National Institute of Drug Abuse; National Institute on Aging; Opiate Addiction; Outcome; Pattern recognition receptor; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Pilot Projects; Plasma; Positioning Attribute; Publications; Pulmonary Fibrosis; Research; Research Personnel; Research Support; Research Training; Role; Sampling; Syndrome; Systems Biology; Toll-like receptors; Training; Training Programs; United States; United States National Institutes of Health; Vaccination; Vaccines; Whole Blood; Work; adaptive immune response; age effect; age related; analytical method; authority; base; career; career development; design; education research; frailty; immunosenescence; improved; influenza virus vaccine; interest; medical schools; metabolic profile; metabolomics; mid-career faculty; mouse model; next generation; opioid therapy; patient oriented research; post-doctoral training; programs; receptor function; recruit; research study; response; success; transcriptome sequencing; transcriptomics; vaccine response; young adult

This renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research is intended to promote mentoring activities and career development focused on studies of the effects of aging on the human immune system. Notably, no other currently funded K24 at the NIA is devoted to translational immunology. The PI, Dr. Shaw, is Associate Professor of Medicine at the Yale School of Medicine; he is trained in Internal Medicine and Infectious Disease, and in addition has a Ph.D. in Genetics and is a trained immunologist. Dr. Shaw is recognized as an authority on the aging of the human immune system; his lab has a special interest in aging of the innate immune system, and has carried out the largest and most comprehensive studies to date of the consequences of aging on human Toll-like Receptor (TLR) function. In addition, his group has advanced understanding of the effects of age on cellular and gene expression signatures of influenza vaccine response. Dr. Shaw is the Project Leader of an R01 within a competitively renewed U19 Center Grant based at Yale that is part of the NIH Human Immunology Project Consortium. This project will elucidate immunologic, gene expression, and metabolomic signatures of high-dose influenza vaccine response in young, frail and non-frail older adults. Dr. Shaw is also a PI of a new R01 from the NIA focusing on influenza vaccine response in the context of aging and HIV infection. These two initiatives form the platform for the mentoring and career development plan directed to developing new investigators studying the immunology of aging. In addition, a pilot study based on the HIV/aging R01 is proposed to elucidate metabolomics and metabolic profiling signatures of vaccine response. This research platform will be supported by career development activities for the PI that include tutorials in computational biology and gerontologic biostatistics. Dr. Shaw is a PI of the T32- supported research training program for the Section of Infectious Diseases at Yale, and is the Leader of the Pilot and Exploratory Studies Core and Co-Director of the Research Education Core of the Yale Pepper Center, mentoring activities that are concurrent elements within the K24 program. As a result, Dr. Shaw has an unparalleled view of laboratory based aging research at Yale to enhance mentee research training and career development of junior investigators. During the first funding period of this award, Dr. Shaw’s mentees have been highly successful, including NIA GEMSSTAR and Beeson Scholar awardees, and the K24 program was instrumental in the expansion of NIH grant support to Dr. Shaw. The proposed program will further enhance the PI’s ongoing role as a mentor to the next generation of investigators who will advance our understanding of human immunology in the context of aging. !

K24职业中期研究者奖的延续申请旨在 促进辅导活动和职业发展，重点是研究老龄化对人类的影响， 免疫系统值得注意的是，NIA目前没有其他资助的K24致力于翻译免疫学。的 PI，Shaw博士，是耶鲁医学院的医学副教授;他接受过内科学培训， 医学和传染病，此外还拥有博士学位。他是一名训练有素的免疫学家博士 肖被公认为是人类免疫系统老化的权威;他的实验室对以下方面特别感兴趣： 老化的先天免疫系统，并进行了最大和最全面的研究，迄今为止， 衰老对人类Toll样受体（TLR）功能的影响。此外，他的团队已经推进了 了解年龄对流感疫苗应答的细胞和基因表达特征的影响。 博士肖是R 01项目的负责人，该项目位于耶鲁大学的U19中心， 是NIH人类免疫学项目联盟的一部分。该项目将阐明免疫学、基因 年轻、虚弱和非虚弱人群中高剂量流感疫苗应答的表达和代谢组学特征 老年人Shaw博士还是NIA新R 01的PI，重点关注流感疫苗反应 老龄化和艾滋病毒感染的背景下。这两项举措形成了指导和职业的平台 发展计划旨在培养新的研究人员研究衰老的免疫学。另外还有按 基于HIV/衰老R 01的初步研究旨在阐明代谢组学和代谢谱 疫苗反应的特征。该研究平台将得到职业发展活动的支持， PI包括计算生物学和老年生物统计学教程。肖医生是T32的私家侦探 支持耶鲁大学传染病科的研究培训计划，是耶鲁大学传染病科的领导者。 试点和探索性研究的核心和耶鲁胡椒的研究教育核心的共同主任 中心，辅导活动是K24计划中的并发元素。因此，肖博士 在耶鲁大学以实验室为基础的老龄化研究的无与伦比的观点，以加强学员的研究培训， 初级调查员的职业发展。在该奖项的第一个资助期内，肖博士的学员 已经非常成功，包括NIA GEMSSTAR和Beeson Scholar获奖者，以及K24计划 在扩大NIH对肖博士的资助方面发挥了重要作用。该计划将进一步 加强PI作为下一代研究者导师的持续作用，这些研究者将推动我们的 了解衰老背景下的人类免疫学。 !