Midcareer Award in Translational Immunology of Aging

衰老转化免疫学职业中期奖

• 批准号: 10436887
• 负责人: Albert C Shaw
• 金额: $ 18.76万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436887
• 关键词: 21 year old; Adult; Affect; Age; Aging; American; Area; Award; Biogenesis; Biological Models; Biometry; Blood specimen; Capsicum; Clinical; Collaborations; Communicable Diseases; Computational Biology; Computing Methodologies; Development; Development Plans; Doctor of Philosophy; Dose; Elderly; Elements; Environment; Foundations; Funding; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic; Geriatrics; Gerontology; Grant; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human; Immune; Immune response; Immune system; Immunologics; Immunologist; Immunology; Immunophenotyping; Infection; Inflammatory; Influenza; Influenza vaccination; Infrastructure; Innate Immune System; Internal Medicine; Laboratories; Laboratory Research; Leptospirosis; Medical; Medicine; Mentors; Mentorship; Metabolic; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Mitochondria; Molecular Immunology; National Institute of Drug Abuse; National Institute on Aging; Opiate Addiction; Outcome; Pattern recognition receptor; Peripheral Blood Mononuclear Cell; Pilot Projects; Plasma; Positioning Attribute; Publications; Pulmonary Fibrosis; Research; Research Personnel; Research Support; Research Training; Role; Sampling; Syndrome; Systems Biology; Toll-like receptors; Training; Training Programs; United States; United States National Institutes of Health; Vaccination; Vaccines; Whole Blood; Work; adaptive immune response; age effect; age related; analytical method; authority; base; career; career development; comorbidity; design; education research; frailty; immunosenescence; improved; influenza virus vaccine; interest; medical schools; medication-assisted treatment; metabolomics; mid-career faculty; mouse model; next generation; patient oriented research; post-doctoral training; programs; receptor function; recruit; research study; response; success; transcriptome sequencing; transcriptomics; vaccine response; young adult

This renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research is intended to promote mentoring activities and career development focused on studies of the effects of aging on the human immune system. Notably, no other currently funded K24 at the NIA is devoted to translational immunology. The PI, Dr. Shaw, is Associate Professor of Medicine at the Yale School of Medicine; he is trained in Internal Medicine and Infectious Disease, and in addition has a Ph.D. in Genetics and is a trained immunologist. Dr. Shaw is recognized as an authority on the aging of the human immune system; his lab has a special interest in aging of the innate immune system, and has carried out the largest and most comprehensive studies to date of the consequences of aging on human Toll-like Receptor (TLR) function. In addition, his group has advanced understanding of the effects of age on cellular and gene expression signatures of influenza vaccine response. Dr. Shaw is the Project Leader of an R01 within a competitively renewed U19 Center Grant based at Yale that is part of the NIH Human Immunology Project Consortium. This project will elucidate immunologic, gene expression, and metabolomic signatures of high-dose influenza vaccine response in young, frail and non-frail older adults. Dr. Shaw is also a PI of a new R01 from the NIA focusing on influenza vaccine response in the context of aging and HIV infection. These two initiatives form the platform for the mentoring and career development plan directed to developing new investigators studying the immunology of aging. In addition, a pilot study based on the HIV/aging R01 is proposed to elucidate metabolomics and metabolic profiling signatures of vaccine response. This research platform will be supported by career development activities for the PI that include tutorials in computational biology and gerontologic biostatistics. Dr. Shaw is a PI of the T32- supported research training program for the Section of Infectious Diseases at Yale, and is the Leader of the Pilot and Exploratory Studies Core and Co-Director of the Research Education Core of the Yale Pepper Center, mentoring activities that are concurrent elements within the K24 program. As a result, Dr. Shaw has an unparalleled view of laboratory based aging research at Yale to enhance mentee research training and career development of junior investigators. During the first funding period of this award, Dr. Shaw’s mentees have been highly successful, including NIA GEMSSTAR and Beeson Scholar awardees, and the K24 program was instrumental in the expansion of NIH grant support to Dr. Shaw. The proposed program will further enhance the PI’s ongoing role as a mentor to the next generation of investigators who will advance our understanding of human immunology in the context of aging. !

此次续签以患者为中心的研究的K24职业中期研究员奖的目的是 促进辅导活动和职业发展，重点是研究老龄化对人类的影响 免疫系统。值得注意的是，目前NIA没有其他资助的K24致力于翻译免疫学。这个 Pi，Shaw博士，耶鲁医学院医学副教授；他接受过内科培训 此外，他还拥有遗传学博士学位，是一名训练有素的免疫学家。Dr。 肖是公认的研究人类免疫系统老化的权威；他的实验室对 先天免疫系统的老化，并开展了迄今为止规模最大、最全面的研究 衰老对人类Toll样受体(TLR)功能的影响此外，他的团队已经晋级 了解年龄对流感疫苗应答的细胞和基因表达特征的影响。 肖博士是耶鲁大学U19中心助学金中R01的项目负责人，该助学金具有竞争力地更新了 是美国国立卫生研究院人类免疫学项目联盟的一部分。这个项目将阐明免疫学、基因 大剂量流感疫苗在年轻、虚弱和非虚弱人群中的表达和代谢特征 上了年纪的人。肖博士也是NIA新的R01的PI，专注于流感疫苗的反应 老龄化和艾滋病毒感染的背景。这两个倡议构成了指导和职业生涯的平台 开发计划旨在开发研究衰老免疫学的新研究人员。此外，a 建议进行基于HIV/Ageing R01的初步研究，以阐明代谢组学和代谢图谱 疫苗反应的签名。这一研究平台将由以下职业发展活动提供支持 PI包括计算生物学和老年生物统计学的教程。肖博士是T32的私家侦探- 支持耶鲁大学传染病部门的研究培训计划，并是 耶鲁辣椒研究性教育核心研究与探索性研究核心及联席主任 中心，指导活动，这些活动是K24计划中的并发元素。因此，肖博士 耶鲁大学以实验室为基础的老龄化研究的无与伦比的观点，以加强导师的研究培训和 初级侦查员的职业发展。在该奖项的第一个资助期内，邵逸夫博士的学员 已经非常成功，包括NIA GEMSSTAR和比森学者奖获得者，以及K24计划 在扩大NIH对Shaw博士的资助方面发挥了重要作用。拟议的计划将进一步 加强PI作为下一代调查人员导师的持续作用，这些调查人员将推动我们的 在老龄化背景下对人类免疫学的理解。 好了！

项目成果

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.

• DOI: 10.1038/nn.3479
• 发表时间: 2013-09
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Xu, Dongyi;Shen, Weiping;Guo, Rong;Xue, Yutong;Peng, Wei;Sima, Jian;Yang, Jay;Sharov, Alexei;Srikantan, Subramanya;Yang, Jiandong;Fox, David, III;Qian, Yong;Martindale, Jennifer L.;Piao, Yulan;Machamer, James;Joshi, Samit R.;Mohanty, Subhasis;Shaw, Albert C.;Lloyd, Thomas E.;Brown, Grant W.;Ko, Minoru S. H.;Gorospe, Myriam;Zou, Sige;Wang, Weidong
• 通讯作者: Wang, Weidong

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.

• DOI: 10.1126/scisignal.aan2392
• 发表时间: 2017-12-12
• 期刊: Science signaling
• 影响因子: 7.3
• 作者: Molony RD;Nguyen JT;Kong Y;Montgomery RR;Shaw AC;Iwasaki A
• 通讯作者: Iwasaki A

Multiple network-constrained regressions expand insights into influenza vaccination responses.

• DOI: 10.1093/bioinformatics/btx260
• 发表时间: 2017-07-15
• 期刊: Bioinformatics (Oxford, England)
• 作者: Avey S;Mohanty S;Wilson J;Zapata H;Joshi SR;Siconolfi B;Tsang S;Shaw AC;Kleinstein SH
• 通讯作者: Kleinstein SH

Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community.

• DOI: 10.1186/s13722-022-00299-1
• 发表时间: 2022-03-07
• 期刊: Addiction science & clinical practice
• 影响因子: 3.7
• 作者: Biondi BE;Vander Wyk B;Schlossberg EF;Shaw A;Springer SA
• 通讯作者: Springer SA

Age-dependent dysregulation of innate immunity.

• DOI: 10.1038/nri3547
• 发表时间: 2013-12
• 期刊: Nature reviews. Immunology