Midcareer Award in Translational Immunology of Aging

衰老转化免疫学职业中期奖

• 批准号: 8699112
• 负责人: Albert C Shaw
• 金额: $ 16.73万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699112
• 关键词: Affect; Age; Aging; American; Antibody Formation; Area; Award; Baby Booms; Biometry; Clinical; Clinical Research; Clinical Trials; Collaborations; Communicable Diseases; Computational Biology; Computing Methodologies; Contracts; Data; Decision Making; Development; Development Plans; Disease; Doctor of Philosophy; Elderly; Environment; Feasibility Studies; Funding; Future; Gene Expression; Gene Expression Profile; Generations; Genetic; Genome; Geriatrics; Grant; HIV Infections; Health; Highly Active Antiretroviral Therapy; Human; Immune; Immune response; Immune system; Immunologics; Immunologist; Immunology; Immunophenotyping; Impairment; Individual; Infection; Infectious Diseases Research; Influenza vaccination; Internal Medicine; Lead; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Molecular Immunology; Morbidity - disease rate; Mus; National Institute of Allergy and Infectious Disease; National Institute on Aging; Natural Immunity; Nursing Homes; Organism; Outcome; Pattern recognition receptor; Pilot Projects; Pneumonia; Population; Positioning Attribute; Prevention; Research; Research Personnel; Research Training; Risk; Role; Syndrome; System; Toll-like receptors; Training; United States National Institutes of Health; Universities; Vaccination; Vaccines; Work; World War II; age effect; analytical method; authority; base; career; career development; cohort; design; experience; feeding; frailty; immunosenescence; immunosuppressed; improved; influenza virus vaccine; innate immune function; interest; medical schools; member; mortality; multi-component intervention; next generation; oral care; oral microbiome; patient oriented research; professor; programs; receptor; receptor function; response; success

DESCRIPTION (provided by applicant): This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is intended to promote mentoring activities and career development focused on the immunology of aging. Notably, no other currently funded K24 at the NIA is devoted to translational immunology. The PI, Dr. Shaw, is Associate Professor of Medicine at the Yale School of Medicine; he is trained in Internal Medicine and Infectious Disease, and in addition has a Ph.D. in Genetics and is a trained immunologist. Dr. Shaw is recognized as an authority on the aging of the human immune system; his lab has a special interest in aging of the innate immune system, and has carried out the largest and most comprehensive studies to date of the consequences of aging on human Toll-like Receptor (TLR) function. These studies defined features of immunosenescence in the innate immune system, and also demonstrated the linkage between TLR function and adaptive immune responses such as antibody response to influenza vaccine. Although Dr. Shaw has mentored several young investigators who remain in academic research positions, at present his mentoring activities must compete with administrative, clinical and research commitments. In this regard, he is at an ideal point in his career to expand his mentoring activities through the K24 mechanism. Dr. Shaw has recently begun two newly funded projects in patient- oriented research-in the first, he serves as Project Leader for an NIAID contract focusing on understanding age-associated alterations in innate immune pattern recognition receptor function. In the second, he is the PI of an R01 within a U19 Center Grant that is part of the NIH Human Immunophenotyping Consortium. This project will elucidate immunologic and gene expression signatures of influenza vaccine response, and will determine how aging and frailty affect these signatures. These two initiatives form the platform for development of a mentoring and career development plan directed to developing new investigators studying the immunology of aging. In addition, two additional projects would be directly supported by this application: the first, a pilot study of innate immune function in young and older individuals with HIV infection. The second exploratory project leverages an ongoing NIA-sponsored clinical trial at Yale of a multicomponent intervention of upright feeding position and enhanced oral care on nursing home pneumonia prevention. We will evaluate the relationship between innate immune function and results of an ongoing substudy on alterations in oral microbiome composition with enhanced oral care. This research platform will be supported by career development activities that include tutorials in clinical geriatrics, computational biology, and gerontologic biostatistic. Taken together, this program will further enhance the PI's role as a mentor to the next generation of investigators who will advance our understanding of human immunology in the context of aging.

描述（由申请人提供）：本申请为K24中期职业生涯研究者奖在以患者为导向的研究旨在促进辅导活动和职业发展的重点是免疫学老化。值得注意的是，NIA目前没有其他资助的K24致力于翻译免疫学。主要研究者Shaw博士是耶鲁医学院的医学副教授;他接受过内科和传染病方面的培训，此外还拥有博士学位。他是一名训练有素的免疫学家Shaw博士被公认为人类免疫系统老化的权威;他的实验室对先天免疫系统的老化特别感兴趣，并对人类Toll样受体（TLR）功能老化的后果进行了迄今为止最大和最全面的研究。这些研究定义了先天免疫系统中免疫衰老的特征，并且还证明了TLR功能与适应性免疫应答（例如对流感疫苗的抗体应答）之间的联系。虽然肖博士已经指导了几个年轻的研究人员谁留在学术研究职位，目前他的指导活动必须与行政，临床和研究承诺竞争。在这方面，他正处于职业生涯的理想阶段，可以通过K24机制扩大他的辅导活动。Shaw博士最近开始了两个新资助的以患者为导向的研究项目-第一个项目，他担任NIAID合同的项目负责人，重点是了解先天免疫模式识别受体功能中与年龄相关的变化。第二，他是U19中心资助的R 01的PI，该中心是NIH人类免疫表型联盟的一部分。这个项目将阐明流感疫苗反应的免疫学和基因表达特征，并将确定衰老和虚弱如何影响这些特征。这两项举措形成了指导和职业发展计划的发展平台，旨在培养研究衰老免疫学的新研究人员。此外，该应用程序还将直接支持另外两个项目：第一个是对感染艾滋病毒的年轻人和老年人先天免疫功能的试点研究。第二个探索性项目利用了正在进行的NIA在耶鲁大学赞助的临床试验，该试验采用直立进食姿势和加强口腔护理的多组分干预来预防疗养院肺炎。我们将评估先天免疫功能与一项正在进行的关于口腔微生物组组成变化的子研究结果之间的关系，该研究旨在增强口腔护理。这个研究平台将得到职业发展活动的支持，包括临床老年医学，计算生物学和老年生物统计学的教程。总而言之，该计划将进一步增强PI作为下一代研究人员导师的作用，这些研究人员将促进我们对衰老背景下人类免疫学的理解。