Research training in infection, nutrition and neurodevelopment in Uganda

项目概要/摘要 传染病是低收入国家儿童最常见的疾病原因。儿童谁 存活下来的传染病常常会遭受长期的神经发育障碍。营养，特别是 微量营养素缺乏也经常与感染相互作用，从而改变神经发育。然而，准确 与感染相关的神经认知发病率的估计在很大程度上是无法获得的，并且这种情况的发病机制 发病率仍不明确。在此续签申请中，Makerere 与 乌干达大学和印第安纳大学，我们重点培训流行病学和发病机制 感染相关的神经认知障碍，一个被忽视的传染病培训领域，包括 评估微量营养素缺乏和感染相互作用的培训。这方面的创新之处 建议包括：强调与感染相关的长期发病率、来自多个国家的学员的多样化组合 学科，需要对所有学位和博士后学员进行综合核心培训，在后发展 教师职位的博士“管道”以及研究管理培训。该应用程序的目标是 建立乌干达研究人员核心，促进对长期疾病的理解、预防和治疗 与传染病和微量营养素缺乏相关的术语神经认知障碍。我们建议 通过对神经心理学、免疫学和神经心理学等方面的学员进行长期和短期培训来实现这一目标 流行病学，包括营养流行病学；研究管理培训；和实验室的发展 数据中心基础设施。长期培养博士生3名（流行病学、免疫学） 和神经心理学）和3名博士后研究员（传染病流行病学、营养流行病学、 和神经心理学）。所有研究都将包括与神经发育相关的部分。短期 培训将包括实验室、临床和神经心理学方面的研讨会、短期课程和实践培训 评估、测试和技术。实验室能力将通过新的分子设备来扩大 生物学研究、免疫学测试技术人员培训以及实验室技术人员领导力培训。数据中心 将通过改善互联网接入和个性化数据库开发培训来扩大能力 两名高级数据经理。研究管理能力将通过硕士培训来发展 2名管理研究和工商管理领域的研究经理。拟议的培训将产生 一支由研究和公共卫生领导者和管理人员组成的团队，他们有能力共同努力， 了解、预防和治疗与感染相关的神经认知障碍。

Project Summary/Abstract Infectious diseases are the most common cause of illness in children in low-income countries. Children who survive infectious diseases often suffer long-term neurodevelopmental morbidity. Nutrition, and in particular micronutrient deficiency, also frequently interact with infection to alter neurodevelopment. However, accurate estimates of infection-related neurocognitive morbidity are largely unavailable, and the pathogenesis of this morbidity remains poorly characterized. In this renewal application, a partnership between Makerere University, Uganda and Indiana University, we focus on training in the epidemiology and pathogenesis of infection-related neurocognitive impairment, a neglected training area in infectious disease, and include training in assessment of the interactions of micronutrient deficiency and infection. Innovative aspects of this proposal include: the emphasis on infection-related long-term morbidity, a diverse mix of trainees from multiple disciplines, required integrated core training for all degree and post-doctoral trainees, development on a post- doctoral “pipeline” for faculty positions, and training in research administration. The goal of this application is to establish a core of Ugandan researchers who advance the understanding, prevention and treatment of long- term neurocognitive disability associated with infectious diseases and micronutrient deficiency. We propose to accomplish this goal through long- and short-term training for trainees in neuropsychology, immunology and epidemiology, including nutrition epidemiology; training in research administration; and development of lab and data center infrastructure. Long-term training includes training of 3 PhD students (in epidemiology, immunology and neuropsychology) and 3 post-doctoral fellows (in infectious disease epidemiology, nutrition epidemiology, and neuropsychology). All research studies will include a component related to neurodevelopment. Short-term training will include workshop and short-course and hands-on training in lab, clinical and neuropsychology assessment, testing and techniques. Lab capacity will be expanded through new equipment for molecular biology studies, technician training in immunology testing, and lab technologist leadership training. Data center capacity will be expanded through improved internet access and individualized database development training for two senior data managers. Research administration capacity will be developed through Masters training of 2 research managers in management studies and business administration. The proposed training will produce a team of research and public health leaders and administrators who are well equipped to work together to understand, prevent and treat infection-related neurocognitive impairment.