Research training in infection, nutrition and neurodevelopment in Uganda

项目摘要/摘要 传染病是低收入国家儿童患病的最常见原因。孩子们 在传染病中幸存下来的人往往会长期患上神经发育障碍。营养，尤其是 微量营养素缺乏，也经常与感染相互作用，改变神经发育。然而，准确的 与感染相关的神经认知发病率的估计在很大程度上是不可用的，而这种疾病的发病机制 发病率仍然没有很好的特征。在此次续签申请中，Makerere与 大学，乌干达和印第安纳大学，我们的重点是流行病学和发病机制的培训 与感染相关的神经认知障碍，这是传染病中一个被忽视的培训领域，包括 培训以评估微量营养素缺乏与感染之间的相互作用。这方面的创新 建议包括：强调与感染相关的长期发病率，培训人员的多样化组合来自多个 学科，需要对所有学位和博士后实习生进行综合核心培训，发展一个 教授职位和研究管理培训的博士“流水线”。此应用程序的目标是 建立一支由乌干达研究人员组成的核心团队，推动对慢性阻塞性肺疾病的认识、预防和治疗 与感染性疾病和微量营养素缺乏症相关的长期神经认知障碍。我们建议 通过对学员进行长期和短期的神经心理学、免疫学和 流行病学，包括营养流行病学；研究管理方面的培训；以及实验室和 数据中心基础设施。长期培训包括3名博士生的培训(流行病学、免疫学 和神经心理学)和3名博士后研究员(传染病流行病学、营养流行病学、 和神经心理学)。所有的研究都将包括一个与神经发育相关的部分。短期 培训将包括研讨会和短期课程，以及实验室、临床和神经心理学的动手培训 评估、测试和技术。将通过新的分子检测设备扩大实验室能力 生物学研究、免疫学检测技术人员培训和实验室技术人员领导力培训。数据中心 将通过改进互联网接入和个性化数据库开发培训来扩大能力 两位高级数据经理。将通过研究生培训培养研究管理能力 2管理学和工商管理专业的研究经理。拟议的培训将产生 一支由研究和公共卫生领导人和管理人员组成的团队，他们有能力共同努力 了解、预防和治疗感染相关的神经认知障碍。

Project Summary/Abstract Infectious diseases are the most common cause of illness in children in low-income countries. Children who survive infectious diseases often suffer long-term neurodevelopmental morbidity. Nutrition, and in particular micronutrient deficiency, also frequently interact with infection to alter neurodevelopment. However, accurate estimates of infection-related neurocognitive morbidity are largely unavailable, and the pathogenesis of this morbidity remains poorly characterized. In this renewal application, a partnership between Makerere University, Uganda and Indiana University, we focus on training in the epidemiology and pathogenesis of infection-related neurocognitive impairment, a neglected training area in infectious disease, and include training in assessment of the interactions of micronutrient deficiency and infection. Innovative aspects of this proposal include: the emphasis on infection-related long-term morbidity, a diverse mix of trainees from multiple disciplines, required integrated core training for all degree and post-doctoral trainees, development on a post- doctoral “pipeline” for faculty positions, and training in research administration. The goal of this application is to establish a core of Ugandan researchers who advance the understanding, prevention and treatment of long- term neurocognitive disability associated with infectious diseases and micronutrient deficiency. We propose to accomplish this goal through long- and short-term training for trainees in neuropsychology, immunology and epidemiology, including nutrition epidemiology; training in research administration; and development of lab and data center infrastructure. Long-term training includes training of 3 PhD students (in epidemiology, immunology and neuropsychology) and 3 post-doctoral fellows (in infectious disease epidemiology, nutrition epidemiology, and neuropsychology). All research studies will include a component related to neurodevelopment. Short-term training will include workshop and short-course and hands-on training in lab, clinical and neuropsychology assessment, testing and techniques. Lab capacity will be expanded through new equipment for molecular biology studies, technician training in immunology testing, and lab technologist leadership training. Data center capacity will be expanded through improved internet access and individualized database development training for two senior data managers. Research administration capacity will be developed through Masters training of 2 research managers in management studies and business administration. The proposed training will produce a team of research and public health leaders and administrators who are well equipped to work together to understand, prevent and treat infection-related neurocognitive impairment.