Research training in infection, nutrition and neurodevelopment in Uganda

乌干达感染、营养和神经发育研究培训

• 批准号: 10361217
• 负责人: Richard Iwa Idro
• 金额: $ 27.02万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10361217
• 关键词: Administrator; Area; Businesses; Child; Clinical; Communicable Diseases; Data; Databases; Development; Discipline; Educational workshop; Epidemiology; Equipment; Faculty; Goals; Immunology; Indiana; Infection; Infectious Disease Epidemiology; Infrastructure; Internet; Leadership; Molecular Biology; Morbidity - disease rate; Neurocognitive; Neurocognitive Deficit; Neuropsychology; Pathogenesis; Positioning Attribute; Postdoctoral Fellow; Prevention; Public Health; Research; Research Personnel; Research Training; Techniques; Testing; Training; Uganda; Universities; Work; data centers; disability; doctoral student; improved; innovation; laboratory development; low income country; micronutrient deficiency; neglect; neurodevelopment; nutrition; prevent; research study

Project Summary/Abstract Infectious diseases are the most common cause of illness in children in low-income countries. Children who survive infectious diseases often suffer long-term neurodevelopmental morbidity. Nutrition, and in particular micronutrient deficiency, also frequently interact with infection to alter neurodevelopment. However, accurate estimates of infection-related neurocognitive morbidity are largely unavailable, and the pathogenesis of this morbidity remains poorly characterized. In this renewal application, a partnership between Makerere University, Uganda and Indiana University, we focus on training in the epidemiology and pathogenesis of infection-related neurocognitive impairment, a neglected training area in infectious disease, and include training in assessment of the interactions of micronutrient deficiency and infection. Innovative aspects of this proposal include: the emphasis on infection-related long-term morbidity, a diverse mix of trainees from multiple disciplines, required integrated core training for all degree and post-doctoral trainees, development on a post- doctoral “pipeline” for faculty positions, and training in research administration. The goal of this application is to establish a core of Ugandan researchers who advance the understanding, prevention and treatment of long- term neurocognitive disability associated with infectious diseases and micronutrient deficiency. We propose to accomplish this goal through long- and short-term training for trainees in neuropsychology, immunology and epidemiology, including nutrition epidemiology; training in research administration; and development of lab and data center infrastructure. Long-term training includes training of 3 PhD students (in epidemiology, immunology and neuropsychology) and 3 post-doctoral fellows (in infectious disease epidemiology, nutrition epidemiology, and neuropsychology). All research studies will include a component related to neurodevelopment. Short-term training will include workshop and short-course and hands-on training in lab, clinical and neuropsychology assessment, testing and techniques. Lab capacity will be expanded through new equipment for molecular biology studies, technician training in immunology testing, and lab technologist leadership training. Data center capacity will be expanded through improved internet access and individualized database development training for two senior data managers. Research administration capacity will be developed through Masters training of 2 research managers in management studies and business administration. The proposed training will produce a team of research and public health leaders and administrators who are well equipped to work together to understand, prevent and treat infection-related neurocognitive impairment.

项目总结/摘要 传染病是低收入国家儿童最常见的病因。的儿童 传染病幸存者经常遭受长期神经发育疾病。营养，特别是 微量营养素缺乏症也经常与感染相互作用，改变神经发育。然而，准确 感染相关的神经认知发病率的估计在很大程度上是不可用的， 发病率的特征仍然不明确。在这次续约申请中，Makerere和 乌干达大学和印第安纳州大学，我们专注于培训流行病学和发病机制， 感染相关的神经认知障碍，这是一个被忽视的传染病培训领域，包括 在评估微量营养素缺乏和感染的相互作用方面进行培训。创新方面， 建议包括：强调与感染有关的长期发病率，来自多个国家的学员的多样化组合 学科，所有学位和博士后学员所需的综合核心培训，博士后发展， 博士“管道”的教师职位，并在研究管理培训。此应用程序的目标是 建立乌干达研究人员核心，促进对长期- 与传染病和微量营养素缺乏有关的神经认知障碍。我们建议 通过对受训者进行神经心理学、免疫学和 流行病学，包括营养流行病学;研究管理方面的培训;发展实验室和 数据中心基础设施。长期培训包括培训3名博士生（流行病学、免疫学 和神经心理学）和3名博士后研究员（传染病流行病学，营养流行病学， 神经心理学）。所有研究都将包括与神经发育有关的组成部分。短期 培训将包括实验室、临床和神经心理学方面的讲习班、短期课程和实践培训 评估、测试和技术。实验室的能力将通过新的设备扩大分子 生物学研究、免疫学测试技术人员培训和实验室技术人员领导力培训。数据中心 将通过改进因特网接入和个性化数据库开发培训来扩大能力 两名高级数据经理研究管理能力将通过硕士培训， 2名管理学和工商管理研究经理。拟议的培训将产生 一个由研究和公共卫生领导人和管理人员组成的团队，他们有能力共同努力， 了解、预防和治疗感染相关的神经认知障碍。

项目成果

Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme.

• DOI: 10.1186/s12909-017-0962-8
• 发表时间: 2017-07-14
• 期刊: BMC medical education
• 影响因子: 3.6
• 作者: Ssemata AS;Gladding S;John CC;Kiguli S
• 通讯作者: Kiguli S

Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort.

羟基脲可降低经颅多普勒速度并预防原发性中风：乌干达 NOHARM 镰状细胞贫血队列。

• DOI: 10.3324/haematol.2019.231407
• 发表时间: 2020
• 期刊: Haematologica
• 影响因子: 10.1
• 作者: Opoka,RobertO;Hume,HeatherA;Latham,TeresaS;Lane,Adam;Williams,Olatundun;Tymon,Jennifer;Nakafeero,Maria;Kasirye,Phillip;Ndugwa,ChristopherM;John,ChandyC;Ware,RussellE
• 通讯作者: Ware,RussellE

Socio-emotional and adaptive behaviour in children treated for severe anaemia at Lira Regional Referral Hospital, Uganda: a prospective cohort study.

• DOI: 10.1186/s13034-020-00352-4
• 发表时间: 2020-11-26
• 期刊: Child and adolescent psychiatry and mental health
• 影响因子: 5.6
• 作者: Ssemata AS;Opoka RO;Ssenkusu JM;Nakasujja N;John CC;Bangirana P
• 通讯作者: Bangirana P

Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda.

• DOI: 10.4269/ajtmh.20-0199
• 发表时间: 2020-12
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Opoka RO;Conroy AL;Waiswa A;Wasswa R;Tumwine JK;Karamagi C;John CC
• 通讯作者: John CC

Nodding syndrome in Ugandan children--clinical features, brain imaging and complications: a case series.

• DOI: 10.1136/bmjopen-2012-002540
• 发表时间: 2013-05-03
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Idro R;Opoka RO;Aanyu HT;Kakooza-Mwesige A;Piloya-Were T;Namusoke H;Musoke SB;Nalugya J;Bangirana P;Mwaka AD;White S;Chong K;Atai-Omoruto AD;Mworozi E;Nankunda J;Kiguli S;Aceng JR;Tumwine JK
• 通讯作者: Tumwine JK