DiCAYA: South Carolina Youth (Component A)

项目摘要 在2001年至2009年期间，多地点青年糖尿病研究记录了 1型糖尿病（T1 D）和2型糖尿病（T2 D）在青年中的发病率和患病率。这些趋势 在很大程度上是由于少数种族和族裔的发病率增加。不断监视 在青年中诊断出糖尿病对于告知卫生保健系统和产生可检验的假设至关重要 与青年糖尿病的自然史有关，但不能通过现有的国家 由于青年糖尿病的罕见性，因此需要开展基于调查的监测工作。因此，为了响应RFA-DP- 20-001，A部分，我们提出了南卡罗来纳州迪卡雅青年研究，这将确定新的- 在整个研究期间，全州范围内确诊的糖尿病病例。我们的方法是由几乎 在南卡罗来纳州20年的经验，使我们能够在青年中进行糖尿病监测工作， 高效的方式，依赖于我们团队开发的基于电子技术的新型两步法 健康记录（EHR）数据。我们的具体目标是：目标1：确定新诊断的 为了描述南卡罗来纳州的糖尿病发病率， 按年龄、性别、种族/民族和糖尿病类型分类。目标2：每年估计 18岁以下青少年糖尿病，按年龄、性别、种族/民族和糖尿病类型分列，使用数学建模， 确定的发病率数据。南卡罗来纳州是独特的位置，以促进迪卡亚监测 我们采用完善的监控基础设施，以实现最佳效率 同时保持我们卓越的科学严谨性和确认完整性。而且我们 由一个经验丰富、协作和多学科的调查小组组成。最后但同样重要的是， 南卡罗来纳州位于南大西洋人口普查区，非西班牙裔黑人比例高 居民将是至关重要的，以保证整个迪卡亚监测工作的代表性，因为 南卡罗来纳州占所有T1 D病例的21%（非西班牙裔黑人T1 D的48%），占所有T1 D病例的32%。 T2 D事件（70%的非西班牙裔黑人T2 D），由卫生部进行监测。因此，井- 建立和高生产力的南卡罗来纳州团队是唯一的定位，以提供关键信息， 青年糖尿病的患病率和发病率。

PROJECT SUMMARY Between 2001 and 2009, the multi-site SEARCH for Diabetes in Youth study documented marked increases in the incidence and prevalence of type 1 diabetes (T1D) and type 2 diabetes (T2D) among youth. These trends were largely driven by increased incidence rates in racial and ethnic minorities. Ongoing surveillance of diabetes diagnosed in youth is essential to inform health care systems and generate testable hypotheses related to the natural history of diabetes in youth, but it cannot be accomplished through existing national survey-based surveillance efforts because of the rarity of diabetes in youth. Therefore, in response to RFA-DP- 20-001, Component A, we propose the South Carolina DiCAYA Youth study, which will ascertain newly- diagnosed incident diabetes cases statewide throughout the study period. Our approach is informed by almost 20 years of experience in South Carolina that allows us to conduct diabetes surveillance work in youth in a highly efficient manner, relying on a novel 2-step approach developed by our team which builds on electronic health record (EHR) data. Our specific aims are: Aim 1: To ascertain newly-diagnosed cases of incident diabetes in youth < 18 years of age in 2020 - 2024 in order to describe diabetes incidence in South Carolina, by age, sex, race/ethnicity, and diabetes type. Aim 2: To provide annual estimates of the prevalence of diabetes in youth < 18 years, by age, sex, race/ethnicity, and diabetes type, using mathematical modeling and the ascertained incidence data. South Carolina is uniquely positioned to contribute to the DiCAYA surveillance effort by employing our well-established surveillance infrastructure that has been refined for optimal efficiency while maintaining our exceptional levels of scientific rigor and ascertainment completeness. Moreover, we are comprised of a highly-experienced, collaborative and multi-disciplinary investigative team. Last but not least, South Carolina’s location in the South Atlantic census division and high proportion of non- Hispanic black residents will be critical to guaranteeing the representativeness of the overall DiCAYA surveillance effort, as South Carolina has contributed 21% of all incident T1D cases (48% of non-Hispanic black T1D) and 32% of all incident T2D cases (70% of non-Hispanic black T2D) to surveillance conducted by SEARCH. Thus, the well- established and highly- productive South Carolina team is uniquely positioned to provide critical information on the prevalence and incidence of diabetes in youth.