South Carolina Clinical & Translational Research Institute (SCTR)

南卡罗来纳州临床

• 批准号: 10820346
• 负责人: KATHLEEN T. BRADY
• 金额: $ 72.49万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-09 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10820346
• 关键词: Acceleration; Address; Administrative Supplement; Affect; Area; Award; Back; Biomedical Research; Biotechnology; Businesses; Caring; Clinical Research; Collaborations; Country; County; Development; Discipline; Disclosure; Dissemination and Implementation; Diverse Workforce; Economics; Education; Educational Curriculum; Environment; Fostering; Foundations; Funding; Geographic Locations; Grant; Growth; Health; Health Priorities; Health system; Healthcare; Healthcare Systems; Heterogeneity; Home; Human; Individual; Informatics; Intellectual Property; Interdisciplinary Study; Intervention; Investments; Learning; Licensing; Link; Marketing; Medical; Medically Underserved Area; Methodology; Methods; Mission; Occupations; Parents; Pennsylvania; Population Heterogeneity; Positioning Attribute; Process; Productivity; Public Health; Recording of previous events; Research; Research Institute; Research Personnel; Research Training; Resources; Rural; Science; Secure; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Source; South Carolina; Structure; Support System; System; Technology; Therapeutic; Training; Training and Infrastructure; Translating; Translational Research; Translations; Universities; Vision; Work; commercialization; digital health; experience; flexibility; health disparity; improved; innovation; innovative technologies; invention; knowledge base; medically underserved; meetings; method development; new technology; outreach; parent grant; patient population; practice setting; product development; programs; research and development; rural underserved; sabbatical; social health determinants; success; technological innovation; telehealth; tool; translational barrier; translational therapeutics; underserved community

PROJECT SUMMARY – SCTR INSTITUTE Parent Award UL1-TR001450 Since 2009, the South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina (SC) by creating a Learning Health System that supports high- quality clinical and translational research (CTR) and fosters collaboration and innovation. Headquartered at the Medical University of South Carolina (MUSC), SCTR has engaged stakeholders and created statewide partnerships to improve care and address social determinants of health across SC. However, greater than 75% of SC is rural, and all 46 counties contain areas designated as medically underserved, so health disparities remain an issue. Over the next five years, SCTR will strengthen its outreach to these medically underserved areas through collaboration with the Clemson University Health Extension Program and the MUSC Telehealth Center of Excellence. With a focus on implementation and dissemination as well as discovery, we will develop and demonstrate innovative technologies and outreach to improve the health of our stakeholders. We will build on prior successes and introduce innovative approaches to expand CTR across SC through the following aims: Aim 1. Extend and enhance high-quality, innovative, flexible curricula and training experiences for all levels of the CTR workforce, with particular emphasis on enhancing workforce heterogeneity and team science. Aim 2. Engage a diverse group of stakeholders as active partners in CTR to address health care priorities while enhancing the scientific knowledge base about collaboration and engagement. Aim 3. Promote greater inclusion acrossthe full translational spectrumof research by engaging investigators from many disciplines and patient populations from diverse demographic backgrounds and geographic areas. Aim 4. Develop, demonstrate and disseminate innovative methods and processes to address barriers and accelerate the translation of research discoveries to improvements in human health that can be generalized to a variety of practice settings. Aim 5. Enhance the conduct of translational research through the development of secure and innovative informatics and digital health solutions, tools and methodologies that affect every aspect of CTR. SCTR’s vision is to be a major force in facilitating the translation of innovative science into practice to address the health priorities of the citizens of SC and beyond. To achieve this vision, SCTR’s mission is to catalyze the development of methods and technologies that lead to more efficient translation of biomedical discoveries into interventions that improve individual and public health. SCTR will serve as the statewide academic home for CTR, one that is well-integrated with SC’s healthcare systems and provides essential support for innovative, efficient, multidisciplinary research and research training. We will work within SCTR, with our partners across SC and with the CTSA Consortium to realize this vision.

项目概要- SCTR研究所母公司奖UL 1-TR 001450 自2009年以来，南卡罗来纳州临床和转化研究所（SCTR）已经改变了 整个南卡罗来纳州（SC）的研究环境，通过创建一个学习健康系统，支持高， 高质量的临床和转化研究（CTR），并促进合作和创新。总部设在 南卡罗来纳州医科大学（MUSC），SCTR已经与利益相关者合作，并在全州范围内建立了 建立伙伴关系，以改善整个南卡罗来纳州的保健和解决健康的社会决定因素。 SC的75%是农村，所有46个县都包含指定为医疗服务不足的地区，因此卫生 差距仍然是一个问题。在接下来的五年里，SCTR将加强对这些医疗机构的宣传， 通过与克莱姆森大学健康推广计划和 MUSC远程医疗卓越中心。重点是执行和传播， 发现，我们将开发和展示创新技术和推广，以改善健康的 我们的利益相关者。我们将在以往成功的基础上，引入创新方法， 通过以下目标在整个科学部门开展工作： 目标1.为所有级别扩展和加强高质量、创新、灵活的课程和培训经验 的CTR劳动力，特别强调提高劳动力的异质性和团队科学。 目标二。让不同的利益相关者群体作为CTR的积极合作伙伴参与进来，以解决医疗保健优先事项 同时加强关于合作和参与的科学知识基础。 目标3.通过吸引研究人员，促进更大的包容性， 来自许多学科和不同人口统计学背景和地理位置的患者人群 地区 目标4。制定、展示和传播创新方法和程序，以消除障碍， 加速将研究发现转化为可推广的人类健康改善 各种各样的实践环境。 目标5。通过开发安全和创新的 信息学和数字健康解决方案，工具和方法，影响CTR的各个方面。 SCTR的愿景是成为促进创新科学转化为实践的主要力量， 解决南卡罗来纳州及其他地区公民的健康优先事项。为了实现这一愿景，SCTR的使命是 促进方法和技术的发展，从而更有效地翻译生物医学 将新发现转化为改善个人和公共健康的干预措施。SCTR将作为全州 CTR的学术之家，一个与SC的医疗保健系统很好地集成，并提供必要的 支持创新、高效、多学科的研究和研究培训。我们将在SCTR内工作， 与我们在SC和CTSA联盟的合作伙伴一起实现这一愿景。

项目成果

Sex/Gender Differences in Screening for Autism Spectrum Disorder: Implications for Evidence-Based Assessment.

• DOI: 10.1080/15374416.2018.1437734
• 发表时间: 2019-11
• 期刊: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
• 作者: Evans SC;Boan AD;Bradley C;Carpenter LA
• 通讯作者: Carpenter LA

Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC.

• DOI: 10.1016/j.chemosphere.2017.11.019
• 发表时间: 2018-03
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Wenzel AG;Brock JW;Cruze L;Newman RB;Unal ER;Wolf BJ;Somerville SE;Kucklick JR
• 通讯作者: Kucklick JR

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain.

体内周细胞的动态重塑可在成年小鼠脑中保持毛细管覆盖率。

• DOI: 10.1016/j.celrep.2017.12.016
• 发表时间: 2018-01-02
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Berthiaume AA;Grant RI;McDowell KP;Underly RG;Hartmann DA;Levy M;Bhat NR;Shih AY
• 通讯作者: Shih AY

Impedance planimetry values for predicting clinical response following peroral endoscopic myotomy.

• DOI: 10.1055/a-1268-7713
• 发表时间: 2021-06
• 期刊: Endoscopy
• 影响因子: 9.3
• 作者: Moran RA;Brewer Gutierrez OI;Rahden B;Chang K;Ujiki M;Yoo IK;Gulati S;Romanelli J;Al-Nasser M;Shimizu T;Hedberg MH;Cho JY;Hayee B;Desilets D;Filser J;Fortinsky K;Haji A;Fayad L;Sanaei O;Dbouk M;Kumbhari V;Wolf BJ;Elmunzer BJ;Khashab MA
• 通讯作者: Khashab MA

Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration.

• DOI: 10.1038/mp.2015.151
• 发表时间: 2016-08
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: Garcia-Keller C;Kupchik YM;Gipson CD;Brown RM;Spencer S;Bollati F;Esparza MA;Roberts-Wolfe DJ;Heinsbroek JA;Bobadilla AC;Cancela LM;Kalivas PW
• 通讯作者: Kalivas PW