South Carolina Clinical & Translational Research Institute (SCTR)

南卡罗来纳州临床

• 批准号: 10820346
• 负责人: KATHLEEN T. BRADY
• 金额: $ 72.49万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-09 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10820346
• 关键词: Acceleration; Address; Administrative Supplement; Affect; Area; Award; Back; Biomedical Research; Biotechnology; Businesses; Caring; Clinical Research; Collaborations; Country; County; Development; Discipline; Disclosure; Dissemination and Implementation; Diverse Workforce; Economics; Education; Educational Curriculum; Environment; Fostering; Foundations; Funding; Geographic Locations; Grant; Growth; Health; Health Priorities; Health system; Healthcare; Healthcare Systems; Heterogeneity; Home; Human; Individual; Informatics; Intellectual Property; Interdisciplinary Study; Intervention; Investments; Learning; Licensing; Link; Marketing; Medical; Medically Underserved Area; Methodology; Methods; Mission; Occupations; Parents; Pennsylvania; Population Heterogeneity; Positioning Attribute; Process; Productivity; Public Health; Recording of previous events; Research; Research Institute; Research Personnel; Research Training; Resources; Rural; Science; Secure; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Source; South Carolina; Structure; Support System; System; Technology; Therapeutic; Training; Training and Infrastructure; Translating; Translational Research; Translations; Universities; Vision; Work; commercialization; digital health; experience; flexibility; health disparity; improved; innovation; innovative technologies; invention; knowledge base; medically underserved; meetings; method development; new technology; outreach; parent grant; patient population; practice setting; product development; programs; research and development; rural underserved; sabbatical; social health determinants; success; technological innovation; telehealth; tool; translational barrier; translational therapeutics; underserved community

PROJECT SUMMARY – SCTR INSTITUTE Parent Award UL1-TR001450 Since 2009, the South Carolina Clinical and Translational Research Institute (SCTR) has transformed the research environment across South Carolina (SC) by creating a Learning Health System that supports high- quality clinical and translational research (CTR) and fosters collaboration and innovation. Headquartered at the Medical University of South Carolina (MUSC), SCTR has engaged stakeholders and created statewide partnerships to improve care and address social determinants of health across SC. However, greater than 75% of SC is rural, and all 46 counties contain areas designated as medically underserved, so health disparities remain an issue. Over the next five years, SCTR will strengthen its outreach to these medically underserved areas through collaboration with the Clemson University Health Extension Program and the MUSC Telehealth Center of Excellence. With a focus on implementation and dissemination as well as discovery, we will develop and demonstrate innovative technologies and outreach to improve the health of our stakeholders. We will build on prior successes and introduce innovative approaches to expand CTR across SC through the following aims: Aim 1. Extend and enhance high-quality, innovative, flexible curricula and training experiences for all levels of the CTR workforce, with particular emphasis on enhancing workforce heterogeneity and team science. Aim 2. Engage a diverse group of stakeholders as active partners in CTR to address health care priorities while enhancing the scientific knowledge base about collaboration and engagement. Aim 3. Promote greater inclusion acrossthe full translational spectrumof research by engaging investigators from many disciplines and patient populations from diverse demographic backgrounds and geographic areas. Aim 4. Develop, demonstrate and disseminate innovative methods and processes to address barriers and accelerate the translation of research discoveries to improvements in human health that can be generalized to a variety of practice settings. Aim 5. Enhance the conduct of translational research through the development of secure and innovative informatics and digital health solutions, tools and methodologies that affect every aspect of CTR. SCTR’s vision is to be a major force in facilitating the translation of innovative science into practice to address the health priorities of the citizens of SC and beyond. To achieve this vision, SCTR’s mission is to catalyze the development of methods and technologies that lead to more efficient translation of biomedical discoveries into interventions that improve individual and public health. SCTR will serve as the statewide academic home for CTR, one that is well-integrated with SC’s healthcare systems and provides essential support for innovative, efficient, multidisciplinary research and research training. We will work within SCTR, with our partners across SC and with the CTSA Consortium to realize this vision.

项目摘要 - SCTR研究所父母奖UL1-TR001450 自2009年以来，南卡罗来纳州的临床和转化研究所（SCTR）已经改变了 通过建立一个支持高级的学习卫生系统，南卡罗来纳州（SC）的研究环境 优质的临床和转化研究（CTR）以及培养合作与创新。总部位于 南卡罗来纳州医科大学（MUSC），SCTR与利益相关者订婚并在全州创建了 合作伙伴关系，以改善护理和解决社会决定者的健康状况。但是，大于 SC的75％是粗糙的，所有46个县都包含指定为医学欠缺的地区，因此健康 差异仍然是一个问题。在接下来的五年中，SCTR将在医学上加强其对这些的宣传 通过与克莱姆森大学健康扩展计划合作和 MUSC远程医疗卓越中心。专注于实施和传播以及 发现，我们将开发和展示创新技术和推广，以改善 我们的利益相关者。我们将基于先前的成功，并引入创新的方法来扩展CTR 通过以下目的整个SC： 目标1。扩展并增强各级高质量，创新，灵活的课程和培训经验 CTR劳动力的尤其是增强劳动力异质性和团队科学。 AIM 2。与CTR中的一群利益相关者一起作为积极合作伙伴，以解决医疗保健重点 同时增强了有关协作和参与的科学知识基础。 目标3。通过吸引研究人员，促进在完整的翻译谱系中更大的包含 来自潜水员人群和地理的许多学科和患者人群 区域。 目标4。开发，演示和传播创新方法和流程，以解决障碍和 加快研究发现的翻译，以改善人类健康，可以推广 到各种练习环境。 目标5。通过开发安全和创新的发展，增强翻译研究的行为 信息和数字健康解决方案，影响CTR各个方面的工具和方法。 SCTR的愿景是成为促进创新科学转化为实践的主要力量 解决SC及其他地区公民的健康优先事项。为了实现这一愿景，SCTR的使命是 催化方法和技术的开发，从而导致更有效地翻译生物医学 发现改善个人和公共卫生的干预措施。 SCTR将作为全州 CTR的学术住所，与SC的医疗保健系统融合在一起，并提供了必不可少的 支持创新，高效，多学科研究和研究培训。我们将在SCTR中工作 与我们的合作伙伴一起，与CTSA财团一起实现这一愿景。

项目成果

HuR as a molecular target for cancer therapeutics and immune-related disorders.

• DOI: 10.1016/j.addr.2022.114442
• 发表时间: 2022-09
• 期刊: Advanced drug delivery reviews
• 影响因子: 16.1

Time-to-positivity of Mycobacterium avium complex in broth culture associates with culture conversion.

• DOI: 10.1186/s12879-022-07250-4
• 发表时间: 2022-03-12
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Mingora CM;Garcia BA;Mange KC;Yuen DW;Ciesielska M;van Ingen J;Flume PA;Dorman SE
• 通讯作者: Dorman SE

Sex/Gender Differences in Screening for Autism Spectrum Disorder: Implications for Evidence-Based Assessment.

• DOI: 10.1080/15374416.2018.1437734
• 发表时间: 2019-11
• 期刊: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
• 作者: Evans SC;Boan AD;Bradley C;Carpenter LA
• 通讯作者: Carpenter LA

Effects of growing-up milk supplemented with prebiotics and LCPUFAs on infections in young children.

• DOI: 10.1097/mpg.0000000000000252
• 发表时间: 2014-04
• 期刊: Journal of pediatric gastroenterology and nutrition
• 影响因子: 2.9
• 作者: Chatchatee P;Lee WS;Carrilho E;Kosuwon P;Simakachorn N;Yavuz Y;Schouten B;Graaff PL;Szajewska H
• 通讯作者: Szajewska H

Prevalence and predictors of phthalate exposure in pregnant women in Charleston, SC.

• DOI: 10.1016/j.chemosphere.2017.11.019
• 发表时间: 2018-03
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Wenzel AG;Brock JW;Cruze L;Newman RB;Unal ER;Wolf BJ;Somerville SE;Kucklick JR
• 通讯作者: Kucklick JR