Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma
曼氏血吸虫病和乙型肝炎病毒感染对肝细胞癌的相互作用
基本信息
- 批准号:10084616
- 负责人:
- 金额:$ 28.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-09 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AdvocateAffectAfricaAfrica South of the SaharaAfricanAftercareAgeAnimal ModelAntigensBlood CirculationCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCancer EtiologyChronicChronic CareChronic Hepatitis BClinicalCollaborationsCountryDNA Double Strand BreakDataEligibility DeterminationGenesGeneticGoalsHBV GenotypeHIVHIV InfectionsHepaticHepatitis BHepatitis B Surface AntigensHepatitis B VirusHepatitis C virusHepatocyteHumanHuman Herpesvirus 4Human Herpesvirus 8Human PapillomavirusImmune responseImmunityImmunologicsImmunologyIn VitroIncomeInfectionInflammationInflammatoryInterceptInterruptionInvestigationJUN geneLightLiverMalignant NeoplasmsMeasuresMedicalMentorsMesenteryOncogenesOncogenicPathway interactionsPatientsPersonsPhysiologicalPlasmaPraziquantelPrimary carcinoma of the liver cellsProto-OncogenesPublic HealthResearchResidual stateRiskRisk FactorsSchistosoma mansoniSchistosoma mansonii infectionSenegalSiteSystemT cell responseTestingTimeTissuesTreatment EfficacyUgandaUniversitiesVenousVirus DiseasesVirus Replicationcarcinogenicitychronic infectioncytokineeggimprovedinflammatory milieuinsightliver biopsymacrophagemortalitynovelresponsestandard of careviral DNA
项目摘要
Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live
longer, the HCC burden may increase. In prior studies, our team identified chronic infection with hepatitis B
and C viruses (HBV, HCV), HIV and Schistosomiasis mansoni (Sm) as independent risk factors for HCC.
Compared to the US, HCC in sub-Saharan Africa occurs at younger age and more advanced stage with
survival of only months. Proposed is an East and West African partnership between colleagues at Makerere
University in Uganda, Fann University in Senegal and Johns Hopkins University focused on HIV and
hepatocellular carcinoma (HCC) in Africa: The H2A Consortium. Building on long-standing collaborative
research, mentoring and clinical activities in both countries, our overarching goal is to reduce the heavy burden
of HCC in sub-Saharan Africa. We advocate investigating cancer interception strategies using appropriate
medical treatments to interrupt or reverse the impact of HCC-causing infections. To understand our data
demonstrating synergistic interaction between chronic HBV and Sm infections, we will examine HBV clinical
and immunological responses in the periphery and the liver in response to Sm treatment with praziquantel.
Over time, liver Sm-related inflammation transitions from a Th1 to Th2 bias, and we hypothesize this transition
may promote HBV replication. We will evaluate the dynamics of plasma HBV DNA during Sm treatment and
correlate these with contemporaneous changes in plasma cytokines to characterize Th1 shifted inflammation.
We also concurrently examine HBV specific CD4+ and CD8+ T cell responses, and measures of Sm treatment
efficacy. Through investigation of liver biopsies on patients before and after SM treatment as well as with HCC,
we anticipate confirming in humans that Sm is pro-carcinogenic and that Sm treatment only partially diminishes
expression of pro-carcinogenic genes. HIV will be evaluated as a modifier of each relationship. Given our
strong record, the proposed research has a high likelihood for successful contribution to reducing the burden
and improving understanding of chronic infections and HCC in Africa.
肝细胞癌(HCC)在非洲是一种非常常见和致命的癌症,并且是艾滋病毒感染者的生活
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David L Thomas其他文献
Dairy sheep production research at the University of Wisconsin-Madison, USA – a review
- DOI:
10.1186/2049-1891-5-22 - 发表时间:
2014-04-16 - 期刊:
- 影响因子:6.500
- 作者:
David L Thomas;Yves M Berger;Brett C McKusick;Claire M Mikolayunas - 通讯作者:
Claire M Mikolayunas
Preferences and feasibility of long-acting technologies for treatment of hepatitis C virus in low- and middle-income countries: A survey of providers and policymakers.
低收入和中等收入国家治疗丙型肝炎病毒的长效技术的偏好和可行性:对提供者和政策制定者的调查。
- DOI:
10.1111/jvh.13921 - 发表时间:
2024 - 期刊:
- 影响因子:2.5
- 作者:
Neil Gupta;S. Swindells;K. Scarsi;Renae Furl;David L Thomas;E. Weld;Joelle Dountio Ofimboudem;H. Desalegn;S. Hamid;Alethse de la Torre Rosas;Angelica E Miranda;Andrew Owen;Steve Rannard;Lindsey Hiebert;Katherine Sun;John W Ward - 通讯作者:
John W Ward
John G. Bartlett: a transformative, visionary leader of Johns Hopkins Infectious Diseases.
约翰·G·巴特利特 (John G. Bartlett):约翰霍普金斯大学传染病中心一位富有变革精神、富有远见的领导者。
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:11.8
- 作者:
P. Auwaerter;T. C. Quinn;Cynthia L Sears;David L Thomas - 通讯作者:
David L Thomas
David L Thomas的其他文献
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{{ truncateString('David L Thomas', 18)}}的其他基金
Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma
曼氏血吸虫病和乙型肝炎病毒感染对肝细胞癌的相互作用
- 批准号:
10259887 - 财政年份:2020
- 资助金额:
$ 28.27万 - 项目类别:
Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma
曼氏血吸虫病和乙型肝炎病毒感染对肝细胞癌的相互作用
- 批准号:
10689175 - 财政年份:2020
- 资助金额:
$ 28.27万 - 项目类别:
Interaction of Schistosomiasis mansoni and hepatitis B virus infections on hepatocellular carcinoma
曼氏血吸虫病和乙型肝炎病毒感染对肝细胞癌的相互作用
- 批准号:
10471416 - 财政年份:2020
- 资助金额:
$ 28.27万 - 项目类别:
HIV HCV Coinfection Antiviral Therapy and Fibrosis
HIV HCV 合并感染抗病毒治疗和纤维化
- 批准号:
9066124 - 财政年份:2015
- 资助金额:
$ 28.27万 - 项目类别:
HIV HCV Coinfection Antiviral Therapy and Fibrosis
HIV HCV 合并感染抗病毒治疗和纤维化
- 批准号:
8915844 - 财政年份:2015
- 资助金额:
$ 28.27万 - 项目类别:
Dissemination of Patient-Centered Outcomes Research in Hepatitis C Virus to Infec
传播以患者为中心的丙型肝炎病毒感染结果研究
- 批准号:
8464492 - 财政年份:2013
- 资助金额:
$ 28.27万 - 项目类别:
Dissemination of Patient-Centered Outcomes Research in Hepatitis C Virus to Infec
传播以患者为中心的丙型肝炎病毒感染结果研究
- 批准号:
8810682 - 财政年份:2013
- 资助金额:
$ 28.27万 - 项目类别:
GB VIRUS C INFECTION OF MACAQUES: AN HIV VACCINE MODEL
猕猴的 GB 病毒 C 感染:HIV 疫苗模型
- 批准号:
7349792 - 财政年份:2006
- 资助金额:
$ 28.27万 - 项目类别:
GB VIRUS C INFECTION OF MACAQUES: AN HIV VACCINE MODEL
猕猴的 GB 病毒 C 感染:HIV 疫苗模型
- 批准号:
7165343 - 财政年份:2005
- 资助金额:
$ 28.27万 - 项目类别:
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