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Early Brain Development and Childhood Obesity

早期大脑发育和儿童肥胖

基本信息

批准号：
10083804
负责人：
Susan Carnell
金额：
$ 49.88万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10083804
关键词：
6 year old Address Adolescent obesity Adult Affect Behavior Behavioral Brain Brain imaging Breast Feeding Characteristics Child Child Development Childhood Cognitive Collection Cues Data Desire for food Development Dietary intake Eating Behavior Economics Environment Environmental Risk Factor Epidemiology Food Genetic Genetic Predisposition to Disease Genotype Growth Health Home environment Impairment Individual Infant Informal Social Control Intake Intervention Knowledge Life Link Magnetic Resonance Imaging Measures Mediating Mediator of activation protein Metals Modeling Neurologic Obesity Outcome Overweight Parents Pathway interactions Pattern Policies Prevention Process Protocols documentation Public Health Questionnaires Race Research Rewards Risk Role Sampling Statistical Models Structure System Techniques Testing Time Weight Work behavior measurement biobehavior cohort early childhood feeding healthy weight imaging study improved indexing kindergarten neuroimaging neuromechanism obesity genetics obesity in children obesity risk obesogenic prenatal response risk variant sex social

项目摘要

RELEVANCE TO PUBLIC HEALTH Improved understanding of the potential underlying early influences on child obesity is an important first step towards developing effective public health and educational policies. This study aims to examine the role of infant early childhood brain development as a potential mediator linking genetic and pre and post-natal environmental factors known to be associated with obesity, and child appetitive responses, appetitive-related characteristics, and child weight trajectories and outcomes for the first time. With more than one third of US children entering kindergarten currently overweight and at-risk for an array of preventable lifelong physical and metal health conditions, this work addresses a pressing social, economic, and public health concern with significant long-lasting affects.

与公共卫生的相关性改善对儿童肥胖潜在的早期影响的理解是重要的第一步制定有效的公共卫生和教育政策。这项研究的目的是考察婴幼儿早期脑发育作为连接遗传和出生前后的潜在中介已知与肥胖有关的环境因素，以及与儿童食欲相关的食欲反应特征，以及儿童体重轨迹和结果的第一次。美国三分之一以上的人口进入幼儿园的儿童目前超重，并面临一系列可预防的终身身体和金属健康状况，这项工作解决了紧迫的社会、经济和公共卫生问题重大而持久的影响。