The Effect of Resistance Exercise on Craving and Cannabis Use in Individuals with Cannabis Use Disorder

抵抗运动对大麻使用障碍患者的渴望和大麻使用的影响

• 批准号: 10179909
• 负责人: GWENDOLYN Antonia THOMAS
• 金额: $ 9.65万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179909
• 关键词: Effect; Resistance; Exercise; Craving; Cannabis

PROJECT SUMMARY/ABSTRACT Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of problematic cannabis use, identifying effective behavioral strategies for individuals experiencing problems with addiction would offer significant benefits. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD. No prior study has investigated the effects of an acute bout of resistance exercise on cannabis craving and consumption, nor has prior research identified what psychobiological mechanisms may underlie these exercise potentiated effects. The aims of this proposal seek to address these issues by implementing an acute resistance exercise protocol in men and women who have severe cannabis use disorder. This proposal will examine the acute effects of resistance exercise on craving, mood, anxiety, withdrawal symptoms and markers of reward and stress regulation. In addition, this proposal will examine the trajectory of these effects in the subsequent days. Given the NIH/NIDA goal to develop new and improved treatment to help people with substance used disorders achieve and maintain a meaningful and sustained recovery, resistance exercise is a treatment that could produce promising results. Resistance exercise is an intervention that is both easy to implement, readily available, could support abstinence and address psychological effects associated with early withdrawal. The findings of this study will inform the further development of exercise interventions for individuals with cannabis use disorder.

项目摘要/摘要 大麻是使用最广泛的非法药物和危险使用率，大麻 使用障碍(CUD)，近年来持续上升。增加暴露会产生 使用大麻产生有害心理和行为影响的风险更高。鉴于此， 问题大麻使用的流行率增加，确定有效的行为战略 经历成瘾问题的个人将提供显著的好处。锻炼身体， 尤其是抵抗力练习，是一种具有相当大潜力的行为干预 CUD的辅助治疗。此前没有研究调查过急性流感发作的影响。 抵抗运动对大麻的渴望和消费，先前的研究也没有确定 哪些心理生物学机制可能是这些运动强化效应的基础。 这项提案的目的是通过实施一项紧急的 有严重大麻使用障碍的男性和女性的阻力练习方案。这 提案将研究抵抗运动对渴望、情绪、焦虑、 戒断症状以及奖赏和压力调节的标志。此外，这项提议将 在接下来的几天里，看看这些影响的轨迹。 鉴于NIH/NIDA的目标是开发新的和改进的治疗方法来帮助患者 物质使用障碍实现并保持有意义的和持续的康复， 阻力练习是一种可能产生有希望的结果的治疗方法。抵抗力练习是 一种既容易实施，又容易获得的干预措施，可以支持节欲和 解决与早期戒断相关的心理影响。这项研究的结果将 为吸食大麻的个人进一步制定运动干预措施提供信息 无序。