Effects of local adaptation on parallel pathway circuit computations in the retina
局部适应对视网膜并行通路计算的影响
基本信息
- 批准号:10458907
- 负责人:
- 金额:$ 2.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY/ABSTRACT
The retina is an adaptable circuit that is capable of rapidly changing its processing mode with changing
stimulus conditions. This is an enormous undertaking because the retina has to process an unpredictable and
wide-ranging assortment of inputs. An understanding of how local neuron dynamics are coordinated to
produce and alter global network computations is needed for understanding how neural circuits of the brain
are able to flexibly integrate information from many different areas. Advances on this front will have a broad
impact on the ability to design targeted therapies to ameliorate brain disorders. The long-term goal of the
proposed work is to understand how local adaptation mechanisms impact the computational function of
neural circuits like the retina. Signals from the photoreceptors are processed along parallel pathways in the
early part of the retina circuit and later combined. The properties of the visual inputs can modulate the how
these inputs are processed via local adaptation mechanisms. This kind of adaptation has consequences for the
manner in which visual inputs are encoded and processed in the early part of the visual system. The proposed
research during the mentored phase aims to characterize the rod pathway adaptation that leads to a switch in
computational processing of inputs and to determine the consequences for the spatiotemporal encoding of
visual inputs. I will characterize adaptation through the rod-AII pathway for a range of luminance conditions to
build a predictive model and to then determine how this adaptation affects the feature-sensitivity of ON α-
ganglion cells under different luminance conditions. The independent phase research will build on the progress
made during the mentored phase. There are several distinct ganglion cell types that convey information to the
brain about particular visual features - similar to the higher order processing that takes place in the visual
cortex. I will conduct studies to determine how ON and OFF α-ganglion cell types use the same circuitry to
produce computations that are fundamentally distinct beyond their opposite polarities. The objective of this
work is to obtain a better understanding of how mechanisms of local adaptation can reconfigure the
computational functions of diverse circuit components. The University of Washington offers the ideal
environment for my career development and for pursuing this highly interdisciplinary project. I have two
outstanding mentors, an experimentalist and a theorist. I will receive training to become proficient in retina
electrophysiology experiments and take courses to hone my quantitative skills. This training will prepare me to
launch my own lab with an interdisciplinary focus. The proposed research will establish my expertise in the
effects of biophysical mechanisms on sensory circuit computation.
项目摘要/摘要
视网膜是一种可适应的电路,能够随着变化而迅速改变其处理模式
刺激条件。这是一项巨大的任务,因为视网膜必须处理不可预测的和
投入的种类繁多。了解局部神经元动力学是如何协调的
需要产生和改变全局网络计算才能理解大脑的神经回路
能够灵活地集成来自多个不同领域的信息。这方面的进展将具有广泛的
对设计针对性治疗以改善脑部疾病的能力的影响。中国的长期目标是
建议的工作是了解局部适应机制如何影响
像视网膜这样的神经回路。来自光感受器的信号沿着平行的路径在
早期是视网膜回路的一部分,后来结合起来。可视输入的属性可以调整如何
这些投入是通过当地适应机制处理的。这种适应会对
在视觉系统的早期部分对视觉输入进行编码和处理的方式。建议数
在指导阶段的研究旨在表征导致转换的杆状通路适应
对输入进行计算处理,并确定时空编码的结果
视觉输入。我将表征通过Rod-AII途径对一系列亮度条件的适应
建立预测模型,然后确定这种适应如何影响Onα的特征敏感度
不同亮度条件下的神经节细胞。独立阶段的研究将建立在进展的基础上
在指导阶段做出的决定。有几种不同的神经节细胞类型将信息传递给
关于特定视觉特征的大脑--类似于在视觉中发生的更高级别的处理
大脑皮层。我将进行研究,以确定α神经节细胞类型如何使用相同的电路来
产生完全不同的计算,而不是它们相反的极性。这样做的目的是
工作是更好地了解当地适应机制如何重新配置
不同电路元件的计算功能。华盛顿大学提供了理想的
为我的职业发展和追求这个高度跨学科的项目创造了一个良好的环境。我有两个
杰出的导师,一位实验者和一位理论家。我将接受精通视网膜的培训
进行电生理学实验,并参加课程来磨练我的定量技能。这次培训将使我做好准备
启动我自己的实验室,专注于跨学科。拟议的研究将确立我在
生物物理机制对感觉回路计算的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gabrielle Jacqueline Gutierrez其他文献
Gabrielle Jacqueline Gutierrez的其他文献
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{{ truncateString('Gabrielle Jacqueline Gutierrez', 18)}}的其他基金
Effects of local adaptation on parallel pathway circuit computations in the retina
局部适应对视网膜并行通路计算的影响
- 批准号:
10203682 - 财政年份:2020
- 资助金额:
$ 2.77万 - 项目类别:
Effects of Local Adaptation on Parallel Pathway Circuit Computations in the Retina
局部适应对视网膜并行通路电路计算的影响
- 批准号:
10674928 - 财政年份:2018
- 资助金额:
$ 2.77万 - 项目类别:
Effects of local adaptation on parallel pathway circuit computations in the retina
局部适应对视网膜并行通路计算的影响
- 批准号:
9750296 - 财政年份:2018
- 资助金额:
$ 2.77万 - 项目类别:
Effects of local adaptation on parallel pathway circuit computations in the retina
局部适应对视网膜并行通路计算的影响
- 批准号:
10661997 - 财政年份:2018
- 资助金额:
$ 2.77万 - 项目类别:
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