Eardrum function in live and cadaveric ears: Research and clinical relevance

活体耳和尸体耳的鼓膜功能:研究和临床相关性

基本信息

  • 批准号:
    10089435
  • 负责人:
  • 金额:
    $ 40.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-02-08 至 2022-03-14
  • 项目状态:
    已结题

项目摘要

ABSTRACT: Chronic conductive hearing loss due to middle-ear diseases can lead to cochlear neuropathy. While our diagnosis and management of middle-ear diseases are not perfect, in part due to incomplete knowledge of the eardrum function for sound transmission. Multiple contradictory theories of eardrum function have been proposed in the past 150 years. These theories are based on incomplete descriptions and misinterpretation of existing eardrum characterizations. Almost all previous measurements of the eardrum response to sound have used steady-state tonal stimuli, while environmental sounds, such as music, noises and speech, are transient in nature. Little is known about the eardrum transient response in the real world. Incomplete knowledge of the eardrum also limits our views on how to repair the diseased ear. Our first goal in this study is to provide evidence to distinguish between these different theories of the eardrum function. Our second goal is to improve our knowledge of the eardrum response to transient sound. Our third goal is to explore clinical application of the measurement of the eardrum transient response for differential diagnosis of middle-ear diseases. To achieve these goals, we propose three aims in this study. Aim 1 employs a state-of-the-art High Speed Holographic Interferometry System (HSHIS) developed in our laboratory to quantify the eardrum transient responses to acoustic and mechanical transient stimuli, at a very high spatial (>100,000 points) and temporal (>100k frames per second) resolution. ‘Experimental modal analysis’ will be applied to extract three important yet poorly quantified characteristics of the eardrum: (1) natural frequencies; (2) the magnitude and spatial pattern of modal responses; (3) damping. Results in aim 1 will enable us to understand and describe eardrum function with a level of sophistication that has not been available, and resolve contradictory theories of eardrum function. Aim 2 will quantify the eardrum transient response in cadaveric human ears with simulated middle-ear diseases. Results in aim 2 will evaluate eardrum function in pathological ears, and assess the use of our techniques as an objective tool for differential diagnosis of middle-ear diseases. Aim 3 will study the eardrum function in live chinchilla ears in normal and diseased middle ear conditions, such as Otitis Media with Effusion. Very little detailed surface motion of the live eardrum has been reported in the literature, results in aim 3 will fill in that gap. Measurements will be repeated just after euthanasia to directly quantify any post-mortem changes in eardrum function. This aim also serves as a pilot study to evaluate the clinical utility of our system before clinical trials in patients.
文摘:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jeffrey Tao Cheng其他文献

Evaluation of auditory damage after blast exposure in mice.
小鼠爆炸暴露后听觉损伤的评估。
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yutaka Koizumi;Aaron K Remenschneider;Jeffrey Tao Cheng;Christopher J Smalt;Kunio Mizutari;Seiji Kakehata
  • 通讯作者:
    Seiji Kakehata

Jeffrey Tao Cheng的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jeffrey Tao Cheng', 18)}}的其他基金

Middle Ear Nonlinearity in High Intensity Sound: Impact on Hearing Damage and Protection
高强度声音中的中耳非线性:对听力损伤和保护的影响
  • 批准号:
    10443501
  • 财政年份:
    2017
  • 资助金额:
    $ 40.84万
  • 项目类别:
Eardrum function in live and cadaveric ears: Research and clinical relevance
活体耳和尸体耳的鼓膜功能:研究和临床相关性
  • 批准号:
    9427982
  • 财政年份:
    2017
  • 资助金额:
    $ 40.84万
  • 项目类别:
Middle Ear Nonlinearity in High Intensity Sound: Impact on Hearing Damage and Protection
高强度声音中的中耳非线性:对听力损伤和保护的影响
  • 批准号:
    10591539
  • 财政年份:
    2017
  • 资助金额:
    $ 40.84万
  • 项目类别:
Eardrum function in live and cadaveric ears: Research and clinical relevance
活体耳和尸体耳的鼓膜功能:研究和临床相关性
  • 批准号:
    9289242
  • 财政年份:
    2017
  • 资助金额:
    $ 40.84万
  • 项目类别:
Backward and Forward Driven Eardrum Motions
向后和向前驱动鼓膜运动
  • 批准号:
    8248196
  • 财政年份:
    2011
  • 资助金额:
    $ 40.84万
  • 项目类别:
Backward and Forward Driven Eardrum Motions
向后和向前驱动鼓膜运动
  • 批准号:
    8438471
  • 财政年份:
    2011
  • 资助金额:
    $ 40.84万
  • 项目类别:
Backward and Forward Driven Eardrum Motions
向后和向前驱动鼓膜运动
  • 批准号:
    8103605
  • 财政年份:
    2011
  • 资助金额:
    $ 40.84万
  • 项目类别:
Function of the human tympanic membrane
人体鼓膜的功能
  • 批准号:
    7684033
  • 财政年份:
    2008
  • 资助金额:
    $ 40.84万
  • 项目类别:
Function of the human tympanic membrane
人体鼓膜的功能
  • 批准号:
    7613539
  • 财政年份:
    2008
  • 资助金额:
    $ 40.84万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 40.84万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了