Biostatistics and Bioinformatics Core

项目概要-生物统计学和生物信息学 NCI癌症中心支持补助金（CCSG）向Abramson癌症中心（ACC）提供资金， 生物统计学和生物信息学核心（BBC），前身为生物统计学核心，自成立以来一直在 成立于1978年。英国广播公司在2015年的更新中被评为“例外”，作为共享资源的一部分。 组（根据旧FOA）。在目前的资助期间，BBC增加了分析大规模 健康数据，如“组学”数据和电子健康记录数据。ACC支持的生物信息学服务 整合，以提高BBC的集中可用性和成本效益。BBC提供专家 生物统计学、生物信息学和数据管理指导研究的设计、实施和分析 该项目由行政协调会成员进行，并提供设计和分析各方面的培训。核心人员 应用现有的设计和分析方法，并适应或开发新的方法，以解决新的 癌症研究中出现的设计和分析问题。BBC的一个主要责任是支持设计， 进行临床试验。因此，英国广播公司在议定书审查和监测系统中发挥着关键作用， 特别是通过临床试验科学审查和监测委员会。齐龙，博士，教授 生物统计学，自2016年以来一直担任BBC总监，并领导着一个有成就和高度协作的团队 主要来自生物统计学，流行病学和信息学系的教师， 佩雷尔曼医学院。在目前的资助期内，BBC继续成为一个充满活力的存在， 行政协调会，向行政协调会成员提供生物统计、生物信息学和数据管理方面的合作支助 在基础、转化、临床和人口科学研究以及社区外展方面， 参与活动。BBC成员共同撰写了300多份与癌症相关的出版物;合作 与英国广播公司的合作对许多与癌症有关的赠款的资助至关重要，包括7个P01，3个P50， 一个P42，三个U 54和两个U24，如皮肤，胰腺，肺，乳房，胸部，颈部，和 食管癌、血液恶性肿瘤、戒烟研究和环境 致癌，以及27个R 01，一个R37和许多R21，K系列赠款，基金会和国家 政府赠款。此外，英国广播公司成员提供了关键支持，以监测癌症发病率和死亡率 在集水区。ACC成员占使用共享资源的93名研究者中的93名（100%） 在最近的报告所述期间（2018年1月7日至2019年6月30日）。总之，BBC是由一个出色的 生物统计学、生物信息学和数据的合格、多产、多才多艺和高度协作的团队 深入参与支持研究和社区外展的管理专业人员， 英国广播公司提供的服务大大增加了科学研究 严格性和可重复性，对ACC的使命至关重要。

PROJECT SUMMARY – Biostatistics and Bioinformatics Core The NCI Cancer Center Support Grant (CCSG) to the Abramson Cancer Center (ACC) has funded the Biostatistics and Bioinformatics Core (BBC), formerly the Biostatistics Core, continuously since its establishment in 1978. The BBC was rated “Exceptional” in the 2015 renewal as part of a Shared Resources Group (per the old FOA). In the current funding period, the BBC added expertise in methods for analysis of big health data such as `omics data and electronic health records data. ACC-supported bioinformatics services were consolidated to enhance centralized availability and cost-efficiency in the BBC. The BBC provides expert biostatistical, bioinformatics, and data management guidance in the design, conduct and analysis of research projects conducted by ACC members, and offers training in all aspects of design and analysis. Core personnel apply existing design and analysis methodologies, and also adapt or develop new methods to address novel design and analysis issues arising in cancer studies. A major BBC responsibility is to support the design and conduct of clinical trials. As such, the BBC plays a key role in the Protocol Review and Monitoring System, particularly through the Clinical Trials Scientific Review and Monitoring Committee. Qi Long, PhD, Professor of Biostatistics, has served as BBC Director since 2016 and leads an accomplished and highly collaborative team primarily drawn from the faculty of the Department of Biostatistics, Epidemiology and Informatics in the Perelman School of Medicine. In the current funding period, the BBC continued to be a dynamic presence in the ACC, providing collaborative biostatistical, bioinformatics and data management support to ACC members in basic, translational, clinical, and population science research as well as in community outreach and engagement activities. BBC members co-authored more than 300 cancer-related publications; collaboration with the BBC was essential to the funding of many cancer-related grants, including seven P01s, three P50s, one P42, three U54s, and two U24s in areas such as skin, pancreatic, lung, breast, thoracic, cervical, and esophageal cancers, hematologic malignancies, smoking cessation research, and environmental carcinogenesis, as well as 27 R01s, one R37 and numerous R21s, K-series grants, and foundation and state government grants. In addition, BBC members provided key support to monitor cancer incidence and mortality in the catchment area. ACC members accounted for 93 of 93 investigators (100%) using the Shared Resource during the most recent reporting period (07/01/18 – 06/30/19). In summary, the BBC is composed of a superbly qualified, productive, versatile and highly collaborative team of biostatistics, bioinformatics and data management professionals who are deeply involved in supporting research and community outreach and engagement activities in the ACC. The services provided by the BBC substantially increase scientific research rigor and reproducibility and are essential to the mission of the ACC.