Core 1: Translational and Clinical Resource Core

摘要 AACORT的翻译和临床资源核心(TRAC核心)是为了 加快我们对斑秃(AA)发病机制的认识 从我们的GWAS和免疫学研究到新的有效治疗方法。核心预算资源调拨目标将 促进采购特征良好、高质量的人类AA组织样本，与 多种疾病参数，包括详细的临床数据、遗传数据、免疫学和 治疗反应数据。核心预算资源调拨目标将为促进无缝过渡提供指导 从研究设计和规划、生物样本和/或数据的采购，到 生成实验数据，然后与数据核心协调进行分析。这个 TRAC核心将促进调查员与AA登记处和哥伦比亚大学的联系 招聘登记处，并使生物样本的最佳收集和保存以及 协调远距离样品的运输和处理。该核心提供访问 全国斑秃注册数据库，允许访问近11,000人 同意在戒酒协会重新联系进行翻译研究的人。我们还有 创建了我们自己的哥伦比亚大学IRB批准的纽约大都市患者数据库 希望与AA联系以参与研究的区域。此外，核心预算资源调拨目标 CORE将提供数据协调和生物统计学专业知识，以设计临床前和 临床研究。核心预算资源调拨目标将为患者确定和采购AA 用于构建的组织样本(皮肤/头皮、血液、粪便、微生物组、免疫细胞) 人类和小鼠模型的AA表达数据库，这将是一个关键的资源 这将被AACORT的每个组成部分广泛利用。核心预算资源调拨目标 将支持研究项目、试验和可行性研究，并与 数据核心。此外，核心预算资源调拨目标将促进 再生障碍性贫血的临床前和临床研究人员，将从动物模型中获得的知识联系起来 探讨再生障碍性贫血的发病机制、免疫病理及治疗方法。通过促进 从定义明确的患者群体无缝获取生物样本，并支持 为研究人员提供增强科学严谨性的服务，TRAC核心的定位是促进 再生障碍性贫血的病理生理和治疗的翻译研究进展。

ABSTRACT The Translational and Clinical Resource Core (TRAC Core) of the AACORT was developed to expedite the translation of the insight we have gained into alopecia areata (AA) pathogenesis from our GWAS and immunological studies into novel effective treatments. The TRAC Core will facilitate procurement of well-characterized, high quality human AA tissue samples, linked to multiple disease parameters including detailed clinical data, genetic data, immunologic and treatment response data. The TRAC core will provide guidance to foster seamless transition from study design and planning, procurement of biosamples and or data, through to the generation of experimental data, and then coordinate with the DATA Core for analyses. The TRAC core will facilitate investigator interface with the AA registry and the Columbia University Recruitment registry, and enable optimal collection and preservation of biosamples, as well as coordinate transport and processing of samples from distant sites. The core provides access to the National Alopecia Areata Registry Database, allowing access to almost 11,000 individuals who have given consent to be re-contacted for translational research in AA. We have also created our own Columbia University IRB approved database of patients in the NY metropolitan area with AA who wish to be contacted for participation in research. Additionally, the TRAC Core will provide data coordination and biostatistical expertise in the design of pre-clinical and clinical studies. The TRAC Core will provide patient ascertainment and procurement of AA tissue samples (skin/scalp, blood, feces, microbiome, immune cells) for the purpose of building an AA expression database from human and mouse models, which will be a critical resource that will be extensively utilized by each of the AACORT components. The TRAC Core resources will support the Research Project and Pilot and Feasibility studies, and interface closely with the DATA Core. In addition, the TRAC Core will promote communication and collaboration between preclinical and clinical researchers of AA, bridging the knowledge obtained from animal models to investigate the pathogenesis, immunopathology, and treatment of AA. By facilitating seamless access to biosamples from a well-defined patient population, and supporting researchers with services to enhance scientific rigor, the TRAC Core is positioned to facilitate the progress of translational investigation of AA pathophysiology and treatment.