Translational and Precision Medicine Resources Core (TRAP)

陷阱核心摘要 转化和精准医学资源核心（TRAP）核心的开发是为了加快 将基础科学/实验室研究的发现转化为新疗法， 研究人员与所需的服务，以推进到转化和临床领域。此外该 提供的服务将允许非皮肤科医生适当地解决特定的问题， 可能与原发性皮肤疾病或 其他器官系统的皮肤表现，或皮肤反应的治疗。精准医疗是 与最先进的研究和医疗保健的持续发展密不可分。陷阱将提供 尖端的方法，以协助研究人员在生物标志物的发现，评估和验证。我们将 提供复杂的计算分析，生物信息学和数据管理，以推动 新的生物标志物进入临床应用领域，用于基于个体/个性化的风险评估， 疾病进展或预测对治疗的反应。陷阱将弥合板凳之间的差距， 诊所有四个战略服务，每个服务旨在解决特定的翻译障碍。第一，陷阱 将在临床前和临床研究的开发中提供研究设计和生物统计专业知识。 接下来，TRAP将提供皮肤组织和毛囊的确定和获取服务 样品，这是一个关键的资源，一直在我们的机构需求很高，我们预计将广泛 由资源社区成员使用。我们将提供链接到全国斑秃登记处 数据库，从而能够接触到数千名同意再次联系的个人 以进行AA的更多研究。此外，我们将提供鉴定基因组和 能够预测或量化治疗反应的分子生物标志物，以及 生物信息学和统计学指导，以从生成的原始数据中收集有用的生物学见解， 先进的基因组和分子工具。

TRAP CORE ABSTRACT The Translational and Precision Medicine Resources Core (TRAP) core was developed to expedite the translation of findings derived from basic science/bench research into novel therapies, by providing investigators with the services needed to advance into the translational and clinical realm. In addition, the services provided will allow non-dermatologist physicians to appropriately address concerns specific to cutaneous diseases that may be relevant to research in both primary cutaneous disorders, or disorders of other organ systems with cutaneous manifestations, or cutaneous reactions to therapies.Precision medicine is inextricably linked to the continued advance of state of the art research and medical care. The TRAP will offer cutting edge approaches to assist investigators in biomarker discovery, assessment and validation. We will provide sophisticated computational analysis, bioinformatics and data management to drive the movement of novel biomarkers into the realm of clinical use for individual based/personalized risk assessment, monitoring of progression or disease, or predicting response to treatment. The TRAP will bridge the gap between bench and clinic with four strategic Services, each designed to address a particular barrier to translation. First, the TRAP will provide study design and biostatistical expertise in the development of pre-clinical and clinical studies. Next, the TRAP will offer services for the ascertainment and procurement of cutaneous tissue and hair follicle samples, a critical resource that has been in high demand at our institution, and we expect will be extensively utilized by resource community members. We will provide links to the National Alopecia Areata Registry Database, thereby allowing access to several thousand individuals who have given consent to be re-contacted for additional research in AA. Further, we will provide expert consultations in identifying genomic and molecular biomarkers that have the capability to predict or quantify treatment responses, as well as the bioinformatic and statistical guidance to glean useful biological insights from raw data generated from advanced genomic and molecular tools.