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Translational and Precision Medicine Resources Core (TRAP)

转化和精准医学资源核心 (TRAP)

基本信息

批准号：
9765065
负责人：
Julian M. Mackay-Wiggan
金额：
$ 15.49万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9765065
关键词：
Address Basic Science Bioinformatics Biological Biological Assay Biometry Biopsy Caring Clinic Clinical Clinical Research Clinical Trials Design Communities Computer Analysis Consent Consultations Cutaneous Data Databases Disease Gene Expression Gene Expression Microarray Analysis Genomics Glean Hair follicle structure Human Image Individual Institution Institutional Review Boards Link Measurement Medical Molecular Monitor Movement Organ Culture Techniques Outcome Outcome Measure Physicians Protocols documentation Quality of life Reaction Registries Research Research Design Research Personnel Resources Risk Assessment Sample Size Sampling Serum Services Skin Tissue Procurements Tissues Translations Underrepresented Populations Universities Validation Variant alopecia areata registry base biobank biomarker discovery body system cytokine data management design disorder risk exome experimental study genetic epidemiology genome sequencing genome wide association study genomic biomarker human tissue insight member molecular marker next generation sequencing novel marker novel therapeutics patient registry precision medicine preclinical development preclinical study predicting response research study response risk variant skin disorder tool translational medicine treatment response validation studies whole genome

项目摘要

TRAP CORE ABSTRACT The Translational and Precision Medicine Resources Core (TRAP) core was developed to expedite the translation of findings derived from basic science/bench research into novel therapies, by providing investigators with the services needed to advance into the translational and clinical realm. In addition, the services provided will allow non-dermatologist physicians to appropriately address concerns specific to cutaneous diseases that may be relevant to research in both primary cutaneous disorders, or disorders of other organ systems with cutaneous manifestations, or cutaneous reactions to therapies.Precision medicine is inextricably linked to the continued advance of state of the art research and medical care. The TRAP will offer cutting edge approaches to assist investigators in biomarker discovery, assessment and validation. We will provide sophisticated computational analysis, bioinformatics and data management to drive the movement of novel biomarkers into the realm of clinical use for individual based/personalized risk assessment, monitoring of progression or disease, or predicting response to treatment. The TRAP will bridge the gap between bench and clinic with four strategic Services, each designed to address a particular barrier to translation. First, the TRAP will provide study design and biostatistical expertise in the development of pre-clinical and clinical studies. Next, the TRAP will offer services for the ascertainment and procurement of cutaneous tissue and hair follicle samples, a critical resource that has been in high demand at our institution, and we expect will be extensively utilized by resource community members. We will provide links to the National Alopecia Areata Registry Database, thereby allowing access to several thousand individuals who have given consent to be re-contacted for additional research in AA. Further, we will provide expert consultations in identifying genomic and molecular biomarkers that have the capability to predict or quantify treatment responses, as well as the bioinformatic and statistical guidance to glean useful biological insights from raw data generated from advanced genomic and molecular tools.

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