Core B: Biorepository Core

核心 B：生物样本库核心

• 批准号: 10091537
• 负责人: Brock Clarke Christensen
• 金额: $ 39.51万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10091537
• 关键词: Accreditation; Aliquot; American; Archives; Back; Biocompatible Materials; Biological; Biological Assay; Blood; CLIA certified; Caring; Centers of Research Excellence; Charge; Clinical Data; Code; Collaborations; Collection; Communities; Complex; Consultations; DNA Methylation; Databases; Devices; Disease; Ensure; Feces; Foundations; Fresh Tissue; Future; Goals; Human; Human Milk; Immune; Information Systems; Infrastructure; International; Laboratories; Manuals; Measures; Medical; Modernization; Molecular; Molecular Epidemiology; Nucleic Acids; Online Systems; Pathologist; Phase; Pilot Projects; Preparation; Procedures; Process; Protocols documentation; Reagent; Research; Research Personnel; Research Project Grants; Resources; Retrieval; Robotics; Sampling; Secure; Services; Ships; Site; Specimen; Standardization; Structure of nail of toe; System; Technology; Training and Education; Translational Research; Triage; Urine; biobank; college; data archive; design; epidemiologic data; epidemiology study; expectation; experience; genome-wide; medical schools; member; metabolomics; microbiome sequencing; multidisciplinary; preservation; programs; protocol development; sample archive; service member; success; transcriptome sequencing

CORE B ABSTRACT The Biorepository Core has created a state-of-the-art and internationally competitive infrastructure for optimal management and oversight of human biospecimens to support the goals of the Center for Molecular Epidemiology. Biospecimens are the basis of the molecular characterization of both a disease and its host, and are crucial for modern molecular epidemiologic study. Careful handling of biologic samples with well-integrated de-identified specimen coding, tracking and data systems are thereby essential for applying cutting edge technologies to rapidly advance our understanding of the molecular basis of complex disease interactions. In Phase I of our Center, the Biorepository Core efficiently collected, processed, and aliquoted over 115,000 samples from over 21,000 unique and varied biospecimens by implementing robotic paired with manually triaged systems. A CLIA certified component of the Core occupying space renovated in our Phase I COBRE in the new Williamson Translational Research Building now is complete with charge back systems. We further constructed a secure, off-site Biospecimen Resource Facility to store our high quality samples for long-term access and future use. Building on our success in Phase I, we will expand our repertoire of centralized services and volume of samples while preserving rigorous collection, processing and analytic preparation (including nucleic acid extraction) standards for current and downstream analyses. A growing team of established investigators with multidisciplinary experience will provide education, training, consultation, and specialized expertise to the Center. We will enhance our interactive web-based databases and make them more widely available, and design integrated searchable platforms with linkages to clinical and epidemiologic data. In Phase II we will refine and phase-in charge back systems to accelerate our trajectory towards sustainablility and expand utilization of our unique Core resources to other IDeA programs and large-scaled regional, national, and international initiatives. Thus, we established a new coordinated, centralized Biorepository infrastructure that will continue to facilitate the scientific advancements of the Center research projects, and make significant contributions to cross-disciplinary translational research collaborations from the broader scientific community.

核心B摘要 生物储藏核心创造了一个最先进的和具有国际竞争力的基础设施， 管理和监督人类生物标本，以支持分子生物学中心的目标 流行病学。生物标本是疾病及其宿主分子特征的基础， 对现代分子流行病学研究至关重要。仔细处理生物样品， 因此，去识别样本编码、跟踪和数据系统对于应用尖端技术至关重要 技术，以迅速推进我们对复杂疾病相互作用的分子基础的理解。在 我们中心的第一阶段，生物储存核心有效地收集，处理和等分超过115，000 从超过21，000个独特和不同的生物标本中提取样本， 分流系统一个CLIA认证的组成部分，核心占用空间翻新，在我们的第一阶段COBRE， 新的威廉姆森转化研究大楼现在已经完成了收费系统。我们进一步 我们建立了一个安全的，场外生物标本资源设施，以长期储存我们的高质量样本 未来的使用和使用。在第一阶段成功的基础上，我们将扩大我们的中央 服务和样品量，同时保持严格的收集、处理和分析准备 （包括核酸提取）用于当前和下游分析的标准品。不断壮大的团队， 具有多学科经验的资深研究者将提供教育、培训、咨询， 专业知识中心。我们将加强我们的互动网络数据库， 更广泛地提供，并设计与临床和流行病学联系的综合搜索平台， 数据在第二阶段，我们将完善并逐步引入收费系统，以加速我们的发展轨迹， 可持续性，并将我们独特的核心资源的利用扩展到其他IDEA计划和大规模的 区域、国家和国际倡议。因此，我们建立了一个新的协调，集中 生物储存库基础设施将继续促进中心研究的科学进步 项目，并作出重大贡献，跨学科的翻译研究合作，从 更广泛的科学界。