Pixel Array Detector for X-ray Crystallography

用于 X 射线晶体学的像素阵列探测器

• 批准号: 7837844
• 负责人: STEVEN E EALICK
• 金额: $ 183.53万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-25 至 2012-08-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7837844
• 关键词: Area; Crystallography; Data; Data Collection; Funding; Future; Generations; Indium; National Center for Research Resources; Noise; Photons; Radiation; Research Personnel; Signal Transduction; Silicon; Slice; Source; Speed; Synchrotrons; System; Visit; X-Ray Crystallography; base; detector; improved; sensor

DESCRIPTION (provided by applicant): The introduction of pixel array detectors (PADs) for macromolecular crystallography at synchrotron beam lines offers an exceptional opportunity for creative applications with potential for breakthrough discoveries. PADs are generally considered to be the near-term replacement for CCD-based detectors at third generation synchrotron beam lines. Each pixel of the PAD module constitutes an independent single-photon counting system, comprising a p-n diode silicon sensor indium bump bonded to a radiation-hardened CMOS readout unit. PADs have many advantages compared to the current generation of detectors. Unlike CCD-based detectors, PADs have no readout noise and will results in improved signal-to-noise. In addition PADs have much higher dynamic range and much higher readout speed compared to CCD detectors. The fast readout speed (3.5 ms) offers the possibility of shutterless data collection, which will increase data collection throughput by one to two orders of magnitude. It will also allow for micro-phi-slicing, which will improve data scaling and merging resulting from detailed analysis of crystal mosaicity. The advantages are particularly important for microdiffraction, which is one of our major areas of emphasis. We propose to acquire a PILTAUS 6M PAD, the first commercially available PAD suitable for macromolecular crystallography at synchrotron beam lines. The PILATUS detector will be installed at the Northeast Collaborative Access Team (NE-CAT) beam line 24-ID-C at the Advanced Photon Source. NE-CAT is funded by NCRR as a national user facility and serves a diverse group of investigators. There is a clear need for the PILATUS 6M PAD. During the past year more than 50 NIH-funded PIs used our facilities on multiple visits, resulting in many important new findings. The PILATUS detector will further enhance our capabilities and facilitate a broad range of current and future NIH-funded projects.

描述（由申请人提供）：在同步加速器光束线上引入用于大分子晶体学的像素阵列检测器（PAD）为具有突破性发现潜力的创造性应用提供了一个绝佳的机会。在第三代同步辐射光束线上，PAD被普遍认为是CCD探测器的近期替代品。PAD模块的每个像素构成独立的单光子计数系统，包括接合到辐射硬化CMOS读出单元的p-n二极管硅传感器铟凸块。与当前一代探测器相比，PAD具有许多优势。与基于CCD的探测器不同，PAD没有读出噪声，并且将导致改善的信噪比。此外，与CCD探测器相比，PAD具有更高的动态范围和更高的读出速度。快速读出速度（3.5 ms）提供了无快门数据采集的可能性，这将使数据采集吞吐量提高一到两个数量级。它还将允许微phi切片，这将改善晶体镶嵌性详细分析产生的数据缩放和合并。这些优势对于显微衍射尤其重要，这是我们的主要重点领域之一。我们建议获得PILTAUS 6 M PAD，这是第一个适用于同步加速器光束线上大分子晶体学的商用PAD。PILLET探测器将安装在高级光子源的东北合作访问团队（NE-CAT）光束线24-ID-C处。NE-CAT由NCRR资助，作为一个国家用户设施，为各种调查人员提供服务。对PILLENT 6 M PAD有明确的需求。在过去的一年中，超过50个NIH资助的PI使用我们的设施进行多次访问，产生了许多重要的新发现。PILLENT探测器将进一步增强我们的能力，并促进广泛的当前和未来NIH资助的项目。