Pediatric Research: Bench to Bedside to Curbside

儿科研究：从长凳到床边再到路边

• 批准号: 7849158
• 负责人: NINA F SCHOR
• 金额: $ 11.73万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849158
• 关键词: Pediatric Research; bench to bedside

DESCRIPTION (provided by applicant): Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Since then, this relative newcomer to both the clinic and the research laboratory has begun to bear considerable fruit. Identification of the gene defects responsible for metabolic and degenerative diseases and new models for care delivery and preventive medicine in inner cities are examples of contributions of pediatric research to the body of knowledge that spans the gap between the clinic and the basic science laboratory. However, increasing emphasis on revenue generation, care for those who constitute the taxpaying and voting workforce, and repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of pediatric knowledge and the dialogue between the laboratory bench and the pediatric clinic and community. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between developmental biology and clinical practice and between the academic sector and the community. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained fellows the opportunity to engage in and understand basic, clinical, and/or translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic biological principles towards enhancing and developing our understanding of the developmental origins and mechanisms of chronic disease throughout the lifespan. As the productive lifespan of individuals with childhood diseases increases and as our population ages, this understanding becomes crucial to development of preventive and severity-limiting strategies for human disease. PUBLIC HEALTH RELEVANCE: The proposed program will train clinically oriented fellows in research that bridges between laboratory bench and patient bedside and between patient bedside and community. This research will be aimed at understanding the childhood antecedents of chronic disease across the lifespan - a critical emphasis as our population ages and as children with previously life-threatening diseases can now live into productive adulthood.

描述（由申请人提供）：尽管对发展中儿童生物学的独特方面的某些认识显然是在1800年代开始的，但在1900年代之前，儿科才发展为独立的知识和临床学科。从那时起，诊所和研究实验室的这个相对新来者开始有相当大的成果。鉴定导致代谢性和退化性疾病的基因缺陷以及内城市中用于护理医学和预防医学的新模型是小儿研究对知识体体的贡献的例子，这些知识跨越了诊所与基础科学实验室之间的差距。但是，越来越重视收入的产生，对构成纳税和投票劳动力的人的照顾以及医学院债务的偿还使吸引，培养和维持的个人变得越来越困难，他们的兴趣是发展儿童知识的转化体以及实验室养蜂人和实验室班级和pediacric clinic和Pediatric Clinic和Pediatric Clinic和社区之间的兴趣。我们建立和培育场地绝对至关重要。本申请建议利用罗切斯特大学的高质量，互动和跨学科的教师和环境，使经过临床训练的同伴有机会参与和理解基本，临床和/或翻译研究，在这些伙伴中发展思维技能和知识基础，这些技能和知识基础将允许他们在发展和发展开发型的基本生物学原理，以促进我们的开发和机制的理解，从而始终如一地进行启发，以培养良好的原理。随着儿童疾病患者的生产寿命增加，随着我们的人口年龄的增长，这种理解对于发展人类疾病的预防和严重性限制策略至关重要。 公共卫生相关性：拟议的计划将在实验室长凳和患者床边以及患者床边和社区之间的研究中培训以临床为导向的研究员。这项研究的目的是了解整个生命周期的慢性疾病的童年前因 - 随着我们的人口年龄的年龄和以前威胁生命的疾病的儿童，现在可以生活在富有成效的成年中。