Identifying the Causal Alleles for SLE in the SLAM Locus on Human chromosome 1q23

识别人类染色体 1q23 SLAM 基因座中 SLE 的致病等位基因

• 批准号: 7920854
• 负责人: Timothy James Vyse
• 金额: $ 13.24万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7920854
• 关键词: 1q23; Address; Affect; Alleles; Animals; Antibody Formation; Antigen-Antibody Complex; Antigen-Presenting Cells; Apoptotic; Autoantibodies; Autoantigens; B-Lymphocytes; Backcrossings; Bacteria; Breeding; C57BL/6 Mouse; CD4 Positive T Lymphocytes; Cell Nucleus; Cell physiology; Cells; Chromatin; Chromosomes, Human, Pair 1; Code; Commit; Congenic Mice; Defect; Dendritic Cells; Development; Disease; Elements; Embryo; Excision; Exons; Family; Gene Family; Gene Targeting; Gene Transfer Techniques; Genes; Genetic Predisposition to Disease; Genome; Genomic Segment; Genomics; Glomerulonephritis; Haplotypes; Helper-Inducer T-Lymphocyte; Hematopoiesis; Hematopoietic; Hematopoietic stem cells; Human; Human Chromosomes; In Vitro; Knock-in Mouse; Knock-out; Knockout Mice; Lead; Lupus; Lymphocyte antigen; Lymphoid; Mediating; Minor; Mononuclear; Mouse Strains; Mus; Mutation; Pan Genus; Pathogenesis; Pathway interactions; Patients; Phagocytes; Phenotype; Physiological; Play; Predisposition; Principal Investigator; Production; Protein Isoforms; Refuse Disposal; Research Personnel; Role; Serum; Severity of illness; Stem cells; Surface; Susceptibility Gene; Syndrome; System; Systemic Lupus Erythematosus; T-Cell Development; T-Lymphocyte; Technology; Testing; Therapeutic; Tissues; Transgenes; Transgenic Organisms; Variant; base; chronic autoimmune disease; embryonic stem cell; experience; gene function; genetic analysis; homologous recombination; in vivo; lupus-like; macrophage; neutrophil; receptor; research study; response; skills

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