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Identifying the Causal Alleles for SLE in the SLAM Locus on Human chromosome 1q23

Identifying the Causal Alleles for SLE in the SLAM Locus on Human chromosome 1q23
识别人类染色体 1q23 SLAM 基因座中 SLE 的致病等位基因
批准号：
8122189
负责人：
Timothy James Vyse
金额：
$13.67万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8122189
关键词：
1q23AddressAffectAllelesAnimalsAntibody FormationAntigen-Antibody ComplexAntigen-Presenting CellsApoptoticAutoantibodiesAutoantigensB-LymphocytesBackcrossingsBacteriaBreedingC57BL/6 MouseCD4 Positive T LymphocytesCell NucleusCell physiologyCellsChromatinChromosomes, Human, Pair 1CodeCommitCongenic MiceDefectDendritic CellsDevelopmentDiseaseElementsEmbryoExcisionExonsFamilyGene FamilyGene TargetingGene Transfer TechniquesGenesGenetic Predisposition to DiseaseGenomeGenomic SegmentGenomicsGlomerulonephritisHaplotypesHelper-Inducer T-LymphocyteHematopoiesisHematopoieticHematopoietic stem cellsHumanHuman ChromosomesIn VitroKnock-in MouseKnock-outKnockout MiceLeadLupusLymphocyte antigenLymphoidMediatingMinorMononuclearMouse StrainsMusMutationPathogenesisPathway interactionsPatientsPhagocytesPhenotypePhysiologicalPlayPredispositionPrincipal InvestigatorProductionProtein IsoformsRefuse DisposalRegulatory T-LymphocyteResearch PersonnelRoleSerumSeverity of illnessStem cellsSurfaceSusceptibility GeneSyndromeSystemSystemic Lupus ErythematosusT-Cell DevelopmentT-LymphocyteTechnologyTestingTherapeuticTissuesTransgenesTransgenic OrganismsVariantbasechronic autoimmune diseaseembryonic stem cellexperiencegene functiongenetic analysishomologous recombinationin vivolupus-likemacrophageneutrophilreceptorresearch studyresponseskills

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会议论文
Identifying the Causal Alleles for SLE in the SLAM Locus on Human chromosome 1q23
SLE and UC Study
Systemic Lupus Erythematosus and Ulcerative Colitis Study
SLE and UC Study
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