IMPACT OF CPAP ON FUNCTIONAL OUTCOMES IN MILDER OSA

CPAP 对轻度 OSA 功能结果的影响

• 批准号: 7718423
• 负责人: David M Rapoport
• 金额: $ 0.5万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718423
• 关键词: Blood Pressure; Blood Pressure Monitors; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Control Groups; Data; Devices; Disease; Double-Blind Method; Funding; Grant; Hour; Hypertension; Institution; Lead; Methods; Obstructive Sleep Apnea; Organ; Placebos; Questionnaires; Research; Research Personnel; Resources; Sleep; Sleep Apnea Syndromes; Source; Symptoms; Testing; Time; United States National Institutes of Health; Week; diaries; functional improvement; functional outcomes; improved; improved functioning; randomized placebo controlled trial; vigilance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that continuous positive airway pressure (CPAP) will change body organ level symptoms such as the level of sleep apnea and hypertension, which will lead to a decrease in daytime sleepiness and improved daytime functioning. The primary aim is to conduct a double-blind, placebo randomized controlled study of the functional improvement efficacy of CPAP in those with less severe obstructive sleep apnea (OSA) (levels <30). The secondary aims are to document the reduction in subjective and objective daytime sleepiness and in 24-hour mean blood pressure. Subjects will undergo 8 weeks of either real CPAP or CPAP without the PAP. Those on initial sham treatment will crossover to CPAP. Enrollees will complete the Functional Outcome of Sleep Questionnaire (FOSQ), Subjective Test of Sleepiness (ESS), Psychomotor Vigilance Test (PVT), and Epworth Sleepiness Scale (ESS) at the beginning and at the end of 8 weeks. 24-hour blood-pressure monitoring will also be performed at these times. Diaries will be kept. Although CPAP has been shown to improve function in severe OSA, the data regarding its effect on less severe disease has been controversial and the methods flawed in the selection of a proper control group. The investigators will use a new device that effectively serves as a control for CPAP and is safe for use. This study is a multi-center trial.

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