IMPACT OF CPAP ON FUNCTIONAL OUTCOMES IN MILDER OSA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的假设是，持续气道正压(CPAP)会改变睡眠呼吸暂停和高血压水平等身体器官水平的症状，从而减少白天的嗜睡，改善白天的功能。主要目的是进行一项双盲、安慰剂随机对照研究，研究CPAP对阻塞性睡眠呼吸暂停(OSA)程度较轻(30级)患者的功能改善效果。第二个目标是记录主观和客观白天嗜睡的减少以及24小时平均血压的减少。受试者将接受8周的真实的CPAP或没有PAP的CPAP。那些最初接受假治疗的人将过渡到CPAP。入选者将在8周开始和结束时完成睡眠问卷(FOSQ)、嗜睡主观测试(ESS)、精神运动警觉测试(PVT)和Epworth嗜睡量表(ESS)的功能结果。这些时间也将进行24小时血压监测。日记将被保留下来。虽然CPAP已被证明可以改善重度OSA的功能，但关于其对不太严重的疾病的影响的数据一直存在争议，在选择合适的对照组方面，方法也存在缺陷。调查人员将使用一种新的设备，该设备可以有效地作为CPAP的控制，并且可以安全使用。这项研究是一项多中心试验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that continuous positive airway pressure (CPAP) will change body organ level symptoms such as the level of sleep apnea and hypertension, which will lead to a decrease in daytime sleepiness and improved daytime functioning. The primary aim is to conduct a double-blind, placebo randomized controlled study of the functional improvement efficacy of CPAP in those with less severe obstructive sleep apnea (OSA) (levels 30). The secondary aims are to document the reduction in subjective and objective daytime sleepiness and in 24-hour mean blood pressure. Subjects will undergo 8 weeks of either real CPAP or CPAP without the PAP. Those on initial sham treatment will crossover to CPAP. Enrollees will complete the Functional Outcome of Sleep Questionnaire (FOSQ), Subjective Test of Sleepiness (ESS), Psychomotor Vigilance Test (PVT), and Epworth Sleepiness Scale (ESS) at the beginning and at the end of 8 weeks. 24-hour blood-pressure monitoring will also be performed at these times. Diaries will be kept. Although CPAP has been shown to improve function in severe OSA, the data regarding its effect on less severe disease has been controversial and the methods flawed in the selection of a proper control group. The investigators will use a new device that effectively serves as a control for CPAP and is safe for use. This study is a multi-center trial.