Pilot/Exploratory Studies Core

UTMB Claude Pepper老年美国人独立中心(OAIC)的具体目标是：1) 为UTMB调查人员资助的肌肉功能和翻译研究提供核心支持 老年人的功能恢复；2)刺激额外的跨学科翻译的增长 改善老年人肌肉功能和功能恢复的研究项目：a)资助试点 项目研究，以产生有前景的新调查领域的初步数据和b)资金 开发创新技术的开发项目；3)培养未来研究领域的领导者 老年人肌肉功能障碍和残疾的机制、预防和治疗；4)招募 具有与老年人肌肉功能和功能恢复相关的专业知识的知名研究人员 与OAIC焦点相关的跨学科翻译研究，并促进 UTMB调查员和其他OAIC和其他机构的调查员研究肌肉功能和 老年人的功能恢复。 我们下一轮OAIC的主题是：转化肌肉生长和丧失的生物学机制 以改善老年人的功能和恢复。我们的重点是将地球上的基本发现 随着年龄的增长肌肉丢失和再生长机制的临床实践，以促进功能恢复和 预防老年人的残疾。观察性研究将为选择 纳入老年人临床试验的适当的住院期间、出院后和长期结果 患者群体。我们的一般假设是，衰老会引起肌肉轻微但显著的变化。 逐渐导致肌肉丧失并易于发生潜在灾难的生物学和功能 在急性疾病发作期间肌肉质量和功能下降。我们还假设合成代谢 干预措施包括运动/康复、补充氨基酸/蛋白质和激素或其他 药物治疗可以预防年龄和疾病引起的肌肉损失，并降低

The specific aims of the UTMB Claude Pepper Older Americans Independence Center (OAIC) are to: 1) provide core support to funded translational research by UTMB investigators on muscle function and functional recovery in older adults; 2) Stimulate the growth of additional interdisciplinary translational research projects to improve muscle function and functional recovery in older adults by: a) funding pilot project research to generate preliminary data in promising new areas of investigation and b) funding developmental projects to develop innovative technologies; 3) Train future leaders in research in the mechanisms, prevention and treatment of muscle dysfunction and disability in older adults; 4) Recruit established investigators with expertise relevant to muscle function and functional recovery in older adults into interdisciplinary translational research related to the OAIC focus and 5) Foster collaborations between UTMB investigators and investigators at other OAIC and other institutions on studies of muscle function and functional recovery in older adults. The theme for the next cycle of our OAIC is: Translating Biological Mechanisms of Muscle Growth and Loss to Improve Function and Recovery in Older Adults. Our focus is on translating basic discoveries on the mechanisms of muscle loss and re-growth with aging to clinical practice to promote functional recovery and prevent disability in older adults. Observational studies will provide crucial information for selecting appropriate in-hospital, post-discharge, and long-term outcomes for inclusion in clinical trials of geriatric patient populations. Our general hypothesis is that aging induces mild but significant changes in muscle biology and function that progressively lead to muscle loss and predispose to potentially catastrophic declines in muscle mass and function during bouts of acute illness. We also hypothesize that anabolic interventions involving exercise/rehabilitation, amino acid/protein supplementation and hormonal or other pharmacological treatment can prevent the age- and disease-induced muscle loss and reduce the risk of