CLINICAL TRIAL: CD4 T-CELL IMMUNE RESPONSE TO INACTIVATED INFLUENZA VACCINE IN C

临床试验：C 患者对灭活流感疫苗的 CD4 T 细胞免疫反应

• 批准号: 7717948
• 负责人: CORNELIA L DEKKER
• 金额: $ 0.8万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717948
• 关键词: 9 year old; Adult; Blood specimen; CD4 Positive T Lymphocytes; Cells; Child; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Elderly; Enrollment; Funding; Grant; Hemagglutination; Immune response; Institution; Purpose; Research; Research Personnel; Resources; Source; T-Lymphocyte; United States National Institutes of Health; Vaccination; aged; day; influenza virus vaccine; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Purpose of this study is to compare the CD4 T-cell response and the hemagglutination inhibition (HAI) titer basally, at day 7-10 post-vaccination, and at 2 months post-vaccination in the children and adult groups. Approximately 30 subjects - 15 healthy children aged 5-9 years and 15 healthy adults aged 18-49 years will be enrolled in a 2-3 month period. The primary objective of this study is to compare the CD4 T-cell responses basally, at day 7-10 post-vaccination, and at 2 months post-vaccination in 15 healthy 5-9 year-old children with those of 15 healthy 18-49 year-old adults. The secondary objective is to determine the hemagglutination inhibition (HAI) titer of these children and adults basally, and at 2 months post-vaccination for each of the three isolates contained in TIV using the same blood samples as that employed for the T-cell studies.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是比较儿童组和成人组在接种后第7-10天和接种后2个月的基础CD 4 T细胞应答和血凝抑制（HAI）滴度。 约30例受试者- 15例5-9岁的健康儿童和15例18-49岁的健康成人将在2-3个月期间入组。 本研究的主要目的是比较15名5-9岁健康儿童和15名18-49岁健康成人的基础、接种后第7-10天和接种后2个月的CD 4 T细胞应答。 次要目的是使用与T细胞研究所用相同的血液样本，测定这些儿童和成人的基础血凝抑制（HAI）滴度，以及接种后2个月TIV中所含3种分离株的血凝抑制（HAI）滴度。