LUNG DISEASE IN CHILDREN WITH MILD CF LUNG DISEASE

患有轻度 CF 肺病的儿童的肺部疾病

• 批准号: 7717907
• 负责人: Terry E. Robinson
• 金额: $ 0.41万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717907
• 关键词: Age; Air; Bronchiectasis; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Elastases; Funding; Future; Grant; IL8 gene; Image; Institution; Intervention Trial; Lung; Lung diseases; Measurement; Mucous body substance; Natural History; Outcome Measure; Pancreatic Elastase; Pharmaceutical Preparations; Research; Research Personnel; Resources; Score; Source; Specimen; Spirometry; Sputum; Subgroup; Thick; United States National Institutes of Health; Visual; X-Ray Computed Tomography; airway inflammation; base; children with cystic fibrosis; design; prospective; pulmonary function; trial comparing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective, two year natural history study is designed to study changes in spirometry-controlled volumetric lung CT imaging and quantitative CT measurements of air trapping and bronchial airway measurements together with CF CT scoring and traditional pulmonary function measurements, and clinical scores in CF children with initially mild lung disease. In addition, in a subgroup of mild CF children ages 10-18 years who can effectively expectorate and provide sputum specimens, sputum IL-8 and sputum elastase will also be evaluated to assess the effect of airway inflammation on CT measurements and other clinical parameters during this two year natural history study. It is predicted that the spirometry-controlled lung CT imaging & quantitative CT measurements will detect initial and progressive changes in lung disease in CF children with mild lung disease over the two year study period. These initial manifestations of lung disease will be regional air trapping and increased bronchial wall thickness, followed by bronchiectasis and larger airway mucus plugging. These changes should provide more viable outcome measures for future multi-center drug intervention trials compared to traditional CF CT scoring which is based on visual assessment of the CT scans.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项为期两年的自然历史研究旨在研究肺活量计量的体积肺CT成像的变化以及空气捕获和支气管气道测量的定量CT测量，以及CF CT评分和传统的肺功能测量结果，以及最初轻度轻度肺病的CF儿童的临床分数。此外，还将评估10-18岁的轻度CF儿童的子组中，他们还将评估有效期望并提供痰标本的痰液标本，痰液IL-8和痰液弹性酶也将评估以评估这两年自然历史研究中气道炎症对CT测量和其他临床参数的影响。 据预测，在两年的研究期内，肺活量测定控制的肺CT成像和定量CT测量结果将检测患有轻度肺病儿童的肺部疾病的初始和进行性变化。 肺部疾病的这些最初表现将是区域空气捕获和增加支气管壁厚，然后是支气管扩张和较大的气道粘液塞。与传统的CF CT评分相比，这些变化应为将来的多中心药物干预试验提供更可行的结果指标，该试验基于对CT扫描的视觉评估。