LUNG DISEASE IN CHILDREN WITH MILD CF LUNG DISEASE

患有轻度 CF 肺病的儿童的肺部疾病

• 批准号: 7717907
• 负责人: Terry E. Robinson
• 金额: $ 0.41万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717907
• 关键词: Age; Air; Bronchiectasis; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Elastases; Funding; Future; Grant; IL8 gene; Image; Institution; Intervention Trial; Lung; Lung diseases; Measurement; Mucous body substance; Natural History; Outcome Measure; Pancreatic Elastase; Pharmaceutical Preparations; Research; Research Personnel; Resources; Score; Source; Specimen; Spirometry; Sputum; Subgroup; Thick; United States National Institutes of Health; Visual; X-Ray Computed Tomography; airway inflammation; base; children with cystic fibrosis; design; prospective; pulmonary function; trial comparing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective, two year natural history study is designed to study changes in spirometry-controlled volumetric lung CT imaging and quantitative CT measurements of air trapping and bronchial airway measurements together with CF CT scoring and traditional pulmonary function measurements, and clinical scores in CF children with initially mild lung disease. In addition, in a subgroup of mild CF children ages 10-18 years who can effectively expectorate and provide sputum specimens, sputum IL-8 and sputum elastase will also be evaluated to assess the effect of airway inflammation on CT measurements and other clinical parameters during this two year natural history study. It is predicted that the spirometry-controlled lung CT imaging & quantitative CT measurements will detect initial and progressive changes in lung disease in CF children with mild lung disease over the two year study period. These initial manifestations of lung disease will be regional air trapping and increased bronchial wall thickness, followed by bronchiectasis and larger airway mucus plugging. These changes should provide more viable outcome measures for future multi-center drug intervention trials compared to traditional CF CT scoring which is based on visual assessment of the CT scans.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项为期两年的前瞻性自然病程研究旨在研究肺功能测定控制的容积肺CT成像和定量CT空气潴留测量值和支气管气道测量值以及CF CT评分和传统肺功能测量值的变化，以及最初患有轻度肺部疾病的CF儿童的临床评分。此外，在一个年龄为10-18岁的轻度CF儿童亚组中，这些儿童可以有效地咳出痰液并提供痰液标本，还将评价痰液IL-8和痰液弹性蛋白酶，以评估气道炎症对CT测量结果和两年自然史研究期间其他临床参数的影响。 据预测，肺量测定控制的肺部CT成像和定量CT测量将在两年的研究期间检测患有轻度肺部疾病的CF儿童中肺部疾病的初始和进行性变化。 这些肺部疾病的最初表现将是局部空气滞留和支气管壁厚度增加，随后是支气管扩张和更大的气道粘液堵塞。与传统的基于CT扫描视觉评估的CF CT评分相比，这些变化应为未来的多中心药物干预试验提供更可行的结局指标。