Gordon Conference on Catecholamines (2003)

戈登儿茶酚胺会议 (2003)

• 批准号: 6671496
• 负责人: Terry E. Robinson
• 金额: $ 3.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6671496
• 关键词: catecholamines; dopamine; health science research; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The catecholamines dopamine (DA), norepinephrine (NE) and epinephrine play critical roles as hormones/neurotransmitters in the peripheral and central nervous systems. The projections of catecholamine neurons are widely distributed throughout all levels of the neuroaxis, including subcortical and cortical structures, and they are thus posed to influence many different behavioral and psychological functions. Their widespread actions include control of autonomic functions, motor programs, novelty and reward, cognition and mood. Disruption of catecholamine synthesis, release, inactivation and response leads to altered physiology and behavior in animal models and disease states in man including, cardiovascular disease, neurological disorders such as Parkinson's Disease, and psychopathological disorders, including, schizophrenia, depression, ADHD and addiction. This application is a request for support of the 2003 Gordon Conference on Catecholamines, which will seek to illuminate leading research in catecholamine neurobiology, as well as catecholamine function and dysfunction, and will include molecular, systems and behavioral levels of analysis. This conference will facilitate active exchanges among molecular biologists, structural biologists, pharmacologists, physiologists, psychologists, psychiatrists, and neurologists. Although speakers and session leaders will provide an introduction suited for the less acquainted attendee, presentations will be geared to late-breaking, novel and often unpublished findings to bring as many people to the forefront of the field as possible. Sessions are planned on the regulation of catecholamine receptor and transporters, on sex differences and hormonal influences on catecholamine activity, on the regulation of catecholamine neurotransmission, on catecholamine/glutamate interactions, on the role of catecholamines in plasticity, learning and reward, as well as in pathological conditions, including psychosis, neurological disease and addiction.

描述(申请人提供)：儿茶酚胺多巴胺(DA)、去甲肾上腺素(NE)和肾上腺素在外周和中枢神经系统中作为激素/神经递质起着关键作用。儿茶酚胺神经元的投射广泛分布于神经轴的各个水平，包括皮质下和皮质结构，因此它们被认为影响许多不同的行为和心理功能。他们广泛的行为包括对自主神经功能、运动程序、新颖性和奖励、认知和情绪的控制。儿茶酚胺的合成、释放、失活和反应的中断会导致动物模型中的生理和行为改变以及人类的疾病状态，包括心血管疾病、神经疾病(如帕金森病)和精神病理疾病(包括精神分裂症、抑郁症、多动症和成瘾)。这项申请是对2003年戈登儿茶酚胺会议的请求，该会议将寻求阐明儿茶酚胺神经生物学以及儿茶酚胺功能和功能障碍方面的领先研究，并将包括分子、系统和行为水平的分析。本次会议将促进分子生物学家、结构生物学家、药理学家、生理学家、心理学家、精神病学家和神经学家之间的积极交流。虽然演讲者和会议负责人将提供适合不太熟悉的与会者的介绍，但演讲将针对最新的、新颖的、往往未发表的发现，以使尽可能多的人走在该领域的前沿。会议的内容包括儿茶酚胺受体和转运体的调节、性别差异和激素对儿茶酚胺活性的影响、儿茶酚胺神经传递的调节、儿茶酚胺/谷氨酸的相互作用、儿茶酚胺在可塑性、学习和奖励中的作用，以及病理条件，包括精神病、神经疾病和成瘾。