Racial discrimination and drug use: Examining the mediating role of inflammation among African American youth

种族歧视和吸毒：研究非裔美国青年炎症的中介作用

基本信息

批准号：
10133031
负责人：
Tamika Chere' Barkley Zapolski
金额：
$ 16.23万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-04-15 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10133031
关键词：
Address Adolescent Adolescent and Young Adult African American Alcohols Area Behavior Biological Buffers Childhood Chronic Chronic stress Critical Thinking Data Data Set Development Discrimination Distal Drug Addiction Drug usage Ethnic group Funding Genes Goals Health Impairment Inflammation Inflammatory Injury Intervention Life Cycle Stages Longitudinal Studies Marijuana Measurement Measures Mediating Mediation Mediator of activation protein Memory Mental Depression Mental Health Mentored Research Scientist Development Award Methodology Methods Modality Modeling National Institute of Drug Abuse Outcome Pathway interactions Patient Self-Report Pharmaceutical Preparations Physiological Population Prevention Process Public Health Reporting Research Research Project Grants Risk Risk Factors Role Scientist Socialization Stress Testing Training Variant Violence Work Youth aged base biobehavior career critical period drug abuse prevention drug discrimination drug use vulnerability emotional distress experience improved inflammatory marker innovation marijuana use negative affect negative mood peer physical conditioning prospective protective effect protective factors public health relevance racial and ethnic racial discrimination racial identity recruit resilience social stressor

项目摘要

Drug use among youth in the US has high relevance to public health, as it is associated with negative social, mental, and physical health outcomes. Prevention scientists have identified risk factors for drug use vulnerability among adolescent populations; however, such models have largely failed to explain risk for African Americans. Therefore, as noted by NIDA and others, culture-specific risk models are necessary to better understand vulnerability to drug use among African American youth. My long-term career goal is to establish myself as an externally funded expert in developmental risk for drug use and addiction among African Americans. The purpose of the K01 proposal is develop content and methodological expertise on cultural and physiological mechanisms that impact drug risk for African American youth. Thus, with training in these areas, the overall objective of this research project is to 1) examine inflammatory pathways through which discrimination impacts drug use vulnerability among African American youth, 2) protective variables that moderate risk, and 3) potential variations of risk based on assessment modality. The first two objective will be completed using Dr. Gene Brody’s SHAPE dataset, a longitudinal study of 500 African American youth aged 16-21 years. For the third objective, I will recruit 150 African American youth aged 16-18 years to examine inflammatory functioning and drug use vulnerability based on discrimination type and measurement modality across a 12-month period. Testing such models is significant, as it will clarify our understanding on the magnitude of the effect discrimination has on drug use risk among African American youth and specific pathways through which the risk pathway operates. Furthermore, such findings are significant as they will directly impact intervention programming by identifying specific targets within the risk process and important cultural factors to include that can buffer risk. In the final stages of this K01 award period, I will submit an R01 to NIDA to investigate the prospective effect multiple forms of chronic stress have on inflammation and negative affect among African American youth to determine critical periods to intervene within the risk process.

美国青年中的吸毒与公共卫生有很高的相关性，因为它与负面社会有关精神和身体健康结果。预防科学家已经确定了吸毒的危险因素青少年人群之间的脆弱性；但是，这样的模型在很大程度上未能解释非裔美国人。因此，正如NIDA和其他人指出的那样，针对特定文化的风险模型是必要的更好地了解非裔美国人青年在吸毒的脆弱性。我的长期职业目标是将自己确立为非洲毒品使用和成瘾风险的外部资助专家美国人。 K01提案的目的是在文化和影响非裔美国青年的药物风险的生理机制。那是通过这些培训该研究项目的总体目标是1）检查炎症途径歧视会影响非裔美国人青年的药物使用脆弱性，2）保护变量中等风险和3）基于评估方式的风险变化。前两个目标将是使用Gene Brody博士的形状数据集完成，这是一项针对500名非裔美国青年的纵向研究 16-21岁。对于第三个目标，我将招募150名16-18岁的非裔美国青年考试基于歧视类型和测量方式的炎症功能和药物使用脆弱性在一个12个月的时间里。测试这样的模型非常重要，因为它将阐明我们对歧视对非洲裔美国青年和特定的毒品使用风险的影响幅度风险途径运行的途径。此外，这样的发现很重要通过在风险过程中确定特定目标并重要的文化因素包括可以缓冲风险。在此K01颁奖期的最后阶段，我将提交 r01到NIDA，以调查预期效应多种形式的慢性压力对注射和非洲裔美国青年的负面影响是确定在风险过程中进行干预的关键时期。