Mouse Genetics Core
小鼠遗传学核心
基本信息
- 批准号:10238907
- 负责人:
- 金额:$ 32.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-08-05 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAllelesAnimalsAntiviral AgentsAutomobile DrivingBioinformaticsCRISPR/Cas technologyCandidate Disease GeneCatalogsCell LineCellsCollaborationsCommunicable DiseasesComplexCongenic StrainCustomDataData SetDatabasesDevelopmentDiseaseDissectionEnvironmentExperimental DesignsExperimental ModelsFrequenciesFundingGenerationsGenesGeneticGenetic PolymorphismGenetic TranscriptionGenetic VariationGenetic studyGenomeGenotypeGoalsHeritabilityHomeostasisHumanImmuneImmune Response GenesImmune responseImmunogeneticsInbred StrainInbred Strains MiceIndividualInfectionInformaticsKnowledgeLungMediationModelingMolecular Mechanisms of ActionMouse StrainsMusOutcomePathogenesisPathway interactionsPhenotypePopulationPopulation HeterogeneityProcessPublic HealthQuantitative Trait LociResourcesRoleSystemTechnologyValidationVariantViralVirus DiseasesWhole OrganismWorkanalysis pipelinebiodefensecausal variantcell typecost efficientdesignemerging pathogenexperienceexperimental analysisexperimental studygene interactiongenetic architecturegenetic informationgenetic variantgenome editinggenomic datain vivoin vivo Modelmodel developmentmouse geneticsmouse modelpathogenpathogenic virusprogramsresponsetraitwhole genome
项目摘要
Abstract
Mouse models provide highly tractable models with which to assess, identify and mechanistically characterize
the role of genetic variants on infectious disease responses. The Mouse Genetics Core has been at the
forefront of designing experimental crosses, sequence datasets and other mouse resources with which to
investigate and perturb polymorphic immune networks. Following the identification of polymorphic host
genome regions, aberrant mouse lines, and discordant immune spreads or candidate genes and pathways
from human studies (in close collaboration with the Projects and the Systems Genetics and Bioinformatics
core), we will generate a variety of mouse experimental models for the Projects to further assess, identify and
characterize these processes. These models will include F1 panels contrasting variant disease alleles, F2
mapping populations, and mouse strains with modified candidate genes. Concurrently, designing the
appropriate experiments for the study of viral disease requires an understanding of the underlying immune
composition of individuals. Therefore, the Core will identify and further characterize genetic variants impacting
basal immune responses; both intra-cellular as well as at the whole-organism level. These data will be
provided to the projects to enhance their assessment of antiviral and/or perturbed response.
抽象的
小鼠模型提供了高度易于处理的模型,可用于评估、识别和机械表征
遗传变异对传染病反应的作用。小鼠遗传学核心已在
设计实验杂交、序列数据集和其他小鼠资源的最前沿
研究和扰乱多态性免疫网络。多态性宿主鉴定后
基因组区域、异常小鼠系以及不一致的免疫传播或候选基因和途径
来自人类研究(与项目和系统遗传学和生物信息学密切合作
core),我们将为项目生成各种小鼠实验模型,以进一步评估、识别和
描述这些过程的特征。这些模型将包括对比变异疾病等位基因的 F1 组、F2
绘制具有修饰候选基因的种群和小鼠品系。同时,设计
研究病毒性疾病的适当实验需要了解潜在的免疫
个体的组成。因此,核心将识别并进一步表征影响的遗传变异
基础免疫反应;无论是在细胞内还是在整个生物体水平。这些数据将
提供给项目以加强对抗病毒和/或扰乱反应的评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Fernando Pardo-Manuel de Villena其他文献
Nonrandom segregation during meiosis: the unfairness of females
- DOI:
10.1007/s003350040003 - 发表时间:
2001-05-01 - 期刊:
- 影响因子:2.700
- 作者:
Fernando Pardo-Manuel de Villena;Carmen Sapienza - 通讯作者:
Carmen Sapienza
Fernando Pardo-Manuel de Villena的其他文献
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{{ truncateString('Fernando Pardo-Manuel de Villena', 18)}}的其他基金
Project 2: Arsenic- Obesity- Diabetes Interactions
项目 2:砷-肥胖-糖尿病的相互作用
- 批准号:
10570870 - 财政年份:2020
- 资助金额:
$ 32.23万 - 项目类别:
Effect of paternal age on mutational burden and behavior in mice
父亲年龄对小鼠突变负荷和行为的影响
- 批准号:
8229344 - 财政年份:2012
- 资助金额:
$ 32.23万 - 项目类别:
Effect of paternal age on mutational burden and behavior in mice
父亲年龄对小鼠突变负荷和行为的影响
- 批准号:
8451365 - 财政年份:2012
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
8511023 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
8334096 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
8231108 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
8523951 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
7637545 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
An Interdisciplinary program for systems genomics of complex behaviors
复杂行为系统基因组学跨学科项目
- 批准号:
7932971 - 财政年份:2009
- 资助金额:
$ 32.23万 - 项目类别:
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